Melanoma therapy is like a combination lock

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  • 1. Melanoma Therapy is like a combination Lock.Melanoma Therapy is like a combination Lock. You need three drugs, they must be in theright sequence to open the door to your immune system1). Chemo/Radiation to shed dead tumor cells to be taken up by Dentritic Cells (DCs) as antigen presenting Cells (APCs)2).Anti-CTLA-4/AntiPD-1 Blockade to keep the activation on and suppress the Tregs cells function.3). Interluekin-2 for the activation, maintain their cytotoxic function, and their survivalThe end result, the unleashing of the host’s Immune system on the cancer at large.