Preparation of qualitative & quantitative department with equipments for Presented by Patel Jignesh. P. Guided by Mrs Anita Patel Department of pharmaceutics Nootan pharmacy college, visnagar layout SOLID DOSAGE FORM
For Uncoated Tablet For Coating Section For Basic Installation Sq.mtrs . For Ancillary Area Sq.mtrs . 60 30 20 10 AREA REQUIREMENT ENVIRONMENT REQUIREMENT Temperature : 25 ± 5 C Humidity : 55 ± 10 %RH Pressure in Ware House Area: 10 Pascal Pressure in Weighing Area : 20 Pascal Pressure in Tableting Area : 15 Pascal Pressure in Central Corridor : 30 Pascal
WET GRANULATION: some equipment High Shear Granulator Diosna Granulator Gral Mixer/Granulator Granulator with Drying Facility Fluidized Bed Granulator Day Nauta Mixer Processor Double cone/Twin Shell Processor Topo Granulator Special Granulator Roto Granulator Marumerizer
Hardness test: Monsanto hardness tester: Advantage :- convenient low priced Drawback: - Hardness obtained is lesser by 1.5-1.7% compared to later developed instrument. -Instrument use spring which has no standard of compression
Pfizer hardness tester: - Use mechanical principle of plier (instrument for holding things tightly) - Reading are recorded on a dial. Strong cobb tester: - Disadvantage: - Air pump get damaged. Need frequent services -Calibration process is difficult
The label states that: The quantity of active ingredient
Date of manufacturing
Date of expiry.
Information about type of dosage form
Such as SR , IR , Mouth dissolving.
Enteric coated etc.
Packaging label: Printed packaging material Includes formula, Dosage, storage condition, instruction, mfg lic. Number Not changed from batch to batch. Stereo part includes batch no, Mfg. date, Exp date, MRP Changed depends on batch & production date.