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Hinri Labs

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  • 1. Healthcare Institute for Neuro-Recovery and Innovation HINRI Labs © 2009 “ Turning knowledge into practice to transform lives.” Translational
  • 2. Translational Labs
    • A patient-centered approach to:
    • “ Turning knowledge into practice to transform lives.”
    HINRI Labs © 2009
  • 3. HINRI Translational Labs Mission
    • Build a nationally recognized nexus for academia, science, medicine, business, philanthropy, and public policy to advance patient-centered research, rehabilitation, restoration, and recovery from neurological impairments due to injury, disease, or congenital causes.
    HINRI Labs © 2009
  • 4. HINRI Translational Labs Goals
    • Turn knowledge into practice to transform lives by:
      • Creating the nation's leading translational laboratories for spinal cord injury, brain trauma, and neurological disorders with collaboration centers in Atlanta, Palo Alto, and Boston
      • Linking knowledge, ideas, and innovation from the scientific, medical, philanthropic, public policy, investment, and patient communities
    • Create and support clinical trials to speed times between innovation and application:
      • Supporting translational and clinical research
      • Promoting promising new technologies and commercial applications
    HINRI Labs © 2008
  • 5. HINRI Translational Labs Goals (cont.)
    • Develop patient-centric coordinated care models:
      • Collaborate with experts on clinical, physical, emotional,
    • lifestyle, financial, family, friends, community, and faith
    • for optimum capabilities development
    • Engage Venture Philanthropy, Foundations, & Payors:
      • Fostering a pre-competitive environment to evaluate and distribute critical intellectual property from research
      • Establishing best practices and a model standard of care for rehabilitation and restoration
      • Creating economic support and rationalization of care for recovery
    HINRI Labs © 2008
  • 6. HINRI Translational Lab The Problem Statement
    • Institute of Medicine – “it takes 18 years for accepted research to become common practice”, because of:
    • Inadequately focused research
    • Delays in research to trials
    • Delays in trials to specialist providers
    • Delays in specialist knowledge to common practice
    • Delays in treatment applications to help patients
    • Lack of patient-centered treatments – traditional focus is on incomplete SCI rather than acute (1 st 30 days) or complete SCI
    • Reimbursement and Treatment Limits
    HINRI Labs © 2008
  • 7. HINRI Translational Lab The Solution
    • Rapid Dissemination and Translation of Ideas & Best Practices for:
    • Research – coordinate and support new ideas
    • Rehabilitation – Test and develop new individualized patient-centered physical and emotional approaches to rehabilitation
    • Restoration – Promote and conduct clinical trial testing in partnership with researchers, early stage companies and trauma centers
    • Recovery – Provide clinical, emotional, & lifestyle education for individual, family, and friends to optimize recovery and capabilities
    HINRI Labs © 2008
  • 8. Translational Research HINRI Labs © 2008 Atlanta* Boston* Palo Alto* HINRI LABS Finding Patient Centered Solutions Restoration Rehabilitation Recovery * Academia, Science, Medicine, Business, Philanthropy, and Public Policy
  • 9. Translational Rehabilitation HINRI Labs HINRI Labs HINRI Labs Activity-Based Electrophysiology Patients Payors Nutrition/Supplements Mental, Spiritual Emotional Health Locomat & Armin Tissue Regeneration Manual Therapy Medical Monitoring Patient Centered Best Practices Improved Functionality Optimum Capabilities Hyperbaric Chamber Collaboration Traditional Rehab Non-Traditional Rehab Assistive Technology Clinical Trials Clinical Practice Academia, Business HINRI Labs © 2008
  • 10. Translational Restoration HINRI Labs © 2008 Basic Research “ P of P” Research Clinical Research Clinical Practice University Partners HINRI Labs Shepherd Center Trauma Centers “ Proof of Principle” Research – Does the basic science & new ideas hold true for human patients? HINRI Translational Lab’s patient-centered clinical trial platform will foster collaboration between universities and clinical research centers.
  • 11. Translational Recovery HINRI Labs © 2008 Medication Therapy Physical Health Nutrition Socialization Readiness for Employment Education Spirituality Leisure Activities Family and Friends Patient Centered Goals Normality Functionality Fulfillment Independence
  • 12. Hinri LABS Areas of Focus
    • Permanent or irreversible
    • central nervous system disorders
    • Phase 1 - “Complete” Spinal Cord Injury (SCI)
    • Phase 2 - Traumatic Brain Injury (TBI) and Stroke
    • Phase 3 - Neurological Disorders*
    HINRI Labs © 2008 *Disease/Degeneration – Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Parkinson’s, and Alzheimer’s
  • 13. HINRI Labs – Action Plan HINRI Labs © 2008 1A Complete SCI Measurement – Neural Plasticity, Functional Recovery Electrophysiology and Robotics 1B Complete SCI Translation – Bench to Bedside Assistive Technology, Holistic Medicine, Stem Cell Research 2 Brain Injury Measurement and Translation Imaging, Surgery, Pharmaceuticals, Stem Cells, Emerging Therapies 3 Neuro-Disease Neural Injury and Degeneration - Cell death, nerve regeneration and reconnection Basic Research Phase Target Focus Method
  • 14. HINRI Labs – Rehabilitation Phase 1A and 1B
    • Provide the scientific insights, new technologies and novel treatments to test, train and measure functional recovery (neural activity, muscle pattern activity, spinal reflexes and plasticity)
      • Activity-Based Rehabilitation
      • New Drugs, Electrical Stimulation and Cell Transplantation Therapies
      • Train Reaching and Grasping (to improve upper extremity function)
    • Electrophysiology and Robotics (Lokomat and Armin)
      • Control experimental conditions
      • Generate standardized “training” of motor tasks
      • Measure mechanical aspects of functional recovery
    • “ Proof of Principle” Studies
      • Focus on underserved areas of investigation in SCI research
      • Translate animal studies research to human SCI studies
      • Neural mechanisms underlying functional recovery and neural connections across the level of injury
      • Measure Brain Motor Control Assay (BMCA)
      • Functional MRI and diffusion tensor imaging
  • 15. HINRI Labs Timeline 2009 JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC Atlanta – 1A ($3 MM) Atlanta – 1B ($5 MM) Palo Alto – 1A* ($10 MM) Boston – 1A ($2.5 MM) Atlanta – 2 ($7.5 MM) Atlanta – 3 ($5 MM) Phase HINRI Labs © 2008 *10 MM to be raised for Dr. Gary Steinberg and Dr. Graham Creasey at Stanford
  • 16. Test & Develop Best Practices Rehabilitation Business Model Promote/Conduct Clinical Trials Restoration Collaborate on Best Practices Rehabilitation Foundations & Charities Common Mission Collaborate on Best Practices Rehabilitation Venture Philanthropy Common Goals Coordinate & Support Research Strategic Partners Collaboration Translational US Military Wounded Veterans Patients Patient Centered Clinical & Lifestyle Recovery Government, VA, Private Insurance Capital
  • 17. Strategic Partners
    • Location – The Shepherd Center has agreed to provide space on the third floor in their main building
    • University Partners - Emory, Stanford and Harvard/MIT
    • Media – CNN (Dr. Sanjay Gupta)
    • Corporate - Google Health and Microsoft HealthVault
    • SHARE Initiative – a $6MM partnership between Humana, Major League Baseball, Bernie Marcus and the McCormick Foundation to assist Wounded Veterans and their Families at Shepherd (100 participants to date)
  • 18. Venture Philanthropy
    • Corporate Partners
    • Dr. Louis Sullivan* – 3M; Bristol, Myers, Squibb; CIGNA
    • Bernie Marcus – SHARE Initiative, Home Depot ($300 MM)
    • Jeff Arnold – WebMD
    • Bill Ide – Former ABA President, East West Institute
    • Bob Bozeman – Google Health
    • Ron Bachman - Microsoft HealthVault
    • John Brandon – Apple
    • John Moore – Morgan Stanley (Former Head of Global HC)
    • Carter Burton – GE Healthcare Financial Services
    • Sanjay Gupta – CNN Medical Director
    • Steve Case – Former Vice-Chair CECP
    • Anthony Begando – Tenon Consulting
    * Have agreed to collaborate
  • 19. Foundations & Charities Initial Prospect List
    • Foundation Partners :
    • Woodruff
    • Hewlett
    • Bill/Melinda Gates
    • Omidyar Network
    • Google
    • Gordon Moore
    • Henry Kravitz
    • Advisory Panel:
    • David Brailer – Health Evolution Partners
    • Kleiner Perkins - Brooke Buyers
    • Draper Fisher Jurvetson - Steve Jurvetson and Tim Draper
    • James Robinson III – RRE Ventures
    • Pete G. Peterson – Blackstone
    • Silicon Valley Bank – Carlyle Group
    • Bono – Elevation Partners
  • 20.
    • Military Partners
    • Armed Forces Service Organization (AFSO)
    • United Service Organization (USO)
    • Wounded Warrior Project
    • Military Foundations (2) – Tenon Consulting Solutions
    • Advisory Panel
    • Hon. Max Cleland
    • Hon. John McCain (Orson Swindle)
    • Gen. Norman Schwarzkopf
    • Hon. Jeb Bush and/or Hon. Jay Rockefeller
    • Tom Hanks – www. welcomebackveterans .org
    • Robin Williams - Christopher and Dana Reeve Foundation
    • Congressional Service Academy Representatives
    • Former Head(s) of VA or VA Hospital System
    • Secretary of the Army and/or Joint Chiefs
    US Military Initial Prospect List
  • 21. CHT Partnership
    • A CHT “Capabilities” Project
    • – Ross Mason, Fellow CHT
    • The Center for Health Transformation (CHT) will partner with HINRI Translational Labs (Atlanta, Palo Alto, and Boston) to advise, support, and promote the creation of a national nexus, collaboration, and model of a patient-centered standard of care in research, rehabilitation, restoration, and recovery from “permanent” central nervous system disorders.
    HINRI Labs © 2008