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Biblio association DMLA 2010

by Jean-Francois GIRMENS

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Les (5) articles qu'il fallait lire depuis juin 2009... en 10 minutes ("Journées de l'Association DMLA")

Les (5) articles qu'il fallait lire depuis juin 2009... en 10 minutes ("Journées de l'Association DMLA")

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Vers de nouvelles pistes et de nouveaux traitements ?
CT hetero. A risque augmenté de DMLA
Dans les populations sans autre facteurs de risque, heterozygte CT augmente le risque de DMLA, surtout exsudativce
DMLA et rétinopathie diabétique sont les deux patjologies les plus fréquentes dans les pays développés Peu de données sur un éventuel lien entre les deux Peu d’association entre DMLA et RD Or un lien semble exister, uniquement pour les formes exsudatives
Eureye 2182 oatients comparés à 2117 contrôles 49 atrophiques 101 exsudatives
Association significative entre diabéte et néovaisseaux choroidiens Mais pas avec formes précoces et atrophie gféographique NV et atrophie resulteraient donc de mécanismes différents
The results from the Cox proportional hazards models used to examine AREDS data show little evidence of a detrimental effect of cataract surgery on progression to advanced AMD. Use of the Cox regression model allows us to take advantage of a unique feature of AREDS, the ability to examine the effect of important covariates, including time-dependent covariates, on progression to late AMD. Results from the Cox models are not statistically significant and there are no consistent trends among models, with point estimates for risk of neovascular AMD in the harmful direction for the matched pair analyses and in the protective direction for the logistic regression analyses. For GA results, all models had point estimates in the direction of protection, suggesting that it is unlikely that there is any risk of cataract extraction on the development of GA. The absence of any consistent pattern in the direction of harm across models reinforces the conclusion that AREDS data provide little evidence that cataract surgery increases the risk of progression to late AMD.

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