Mo W 10

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Mo W 10

  1. 1. Mycobacterium
 leprae
 •  Gram
+,
rod
 •  Animals
with
lower
temperature
are

 
the
natural
reservoir
‐
armadillos
 •  Pathogen
(latent,
symptoms
absent
un<l
a=er
1
year)
targets
skin,
 peripheral
nerves
and
mucous
membranes
(areas
with
lower
body
 temperature),
transmission
is
not
well‐understood
 •  Causes
Hansen’s
disease
(renaming
of
leprosy
due
to
s<gma)
 •  Tuberculoid
–
mild,
few
skin
lesions,
less
common
disease
 •  Lepromatus
–
severe,
more
than
6
skin
lesions,
skin
numbness
&
 weak
muscles,
claw‐shaped
thumbs
(neuropathy),
renal
failure,
 glaucoma
 •  Numbness
leads
to
repeated,
undetected
injuries
and
loss
of
 digits
or
tes<cles
 •  Treated
with
rifampin,
dapsone
(life<me
an<bio<c
treatment)
 •  250,000
cases
world‐wide
annually
(100
in
the
U.S.)

  2. 2. Bacillus
anthracis
 •  Gram
+,
rod
 •  Pathogen
infects
livestock
that
inhale
spores,
soil
 harbors
spores
that
become
airborne.

Humans
usually
 become
infected
by
contact
with
infected
animals
 (contact
with
an
open
wound
or
consump<on
of
 contaminated
meat),
and
very
rarely
by
inhaling
spores
 •  3
forms
of
anthrax
 •  Mild
skin
lesions,
swollen
lymph
nodes
 •  GI
anthrax
–
nausea,
fever,
bloody
diarrhea
and
vomi<ng,
 swollen
lymph
nodes
 •  Pulmonary
anthrax
–
flu‐like
symptoms,
high
fever,
 meningi<s,
usually
fatal

  3. 3. Herpes
Simplex
I
virus
 •  Member
of
Herpesviridae
–
double‐stranded
DNA,
polyhedral
 protein
capsid,
lipid
envelope
 •  Causes
cold
sores
(oral
herpes),
but
only
because
the
virus
 “prefers”
the
trigeminal
nerve
–
can
infect
any
part
of
the
body
 (skin)
 –  Transferred
by
contact
with
an
infected
person,
virus
present
 even
when
lesions
are
absent
 •  Latent
and
recurrent
virus
–
causes
lesions
 –  Symptoms
may
not
show
up
for
weeks
or
years
 –  Virus
migrates
to
the
nerves
and
travels
back
to
the
skin,
 usually
associated
with
stress
 •  OTC
–
lysine
(amino
acid)
supplementa<on,
Abreva
 •  An<viral
treatment
–
Famvir,
Valtrex


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