프레젠테이션1

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프레젠테이션1

  1. 1. Mapping of complex traits 2010. 4. 9 Jei Kim, MD
  2. 2. (Adopted from Dr. T. A. Manolio’s slides)
  3. 3. GWAS in stroke fields (Atherosclerosis 2009;207:144-149) (BMC Med Genet 2007;8(suppl 1): S11) (BMC Med Genet 2007;8(suppl 1): S17)
  4. 4. Inherited diseases1. Single-gene disorders2. Disorders having complex inheritance - complex interaction between 1) genotype at one or more loci 2) a variety of environmental exposures
  5. 5. Mendelian disorders vs. Common disorders (ref. 2) 1. Mendelian disorders - rare and highly heritable - variation in single gene is both necessary and sufficient to cause disease 2. Common disorders - influenced by several genetic and environmental factors (ref. 2, 3) - cluster in families (ref. 3)

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