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Uncoupling mu receptor tolerance, analgesia, and euphoria: Modification of agonist effects using buprenorphine.

by Asst Clinical Professor of Psychiatry at Medical College of Wisconsin on May 12, 2012

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This pilot study examined 5 patients with severe, chronic pain conditions, and was presented at the 2012 ASAM Annual Meeting in Atlanta. ...

This pilot study examined 5 patients with severe, chronic pain conditions, and was presented at the 2012 ASAM Annual Meeting in Atlanta.
Patients taking 4 mg of buprenorphine daily SL used oxycodone 15 mg, up to every 4 hours as needed in an open-label trial. Patients reported excellent analgesia with NO euphoria, such that even former opioid addicts were able to control use of their agonist each month. Most importantly, buprenorphine anchored tolerance and prevented dose escalation in patients for as long as 5 years, with no sign of tolerance development. Patients continued to get excellent paiin relief for many years, provided buprenorphine was not discontinued.

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Uncoupling mu receptor tolerance, analgesia, and euphoria: Modification of agonist effects using buprenorphine. Uncoupling mu receptor tolerance, analgesia, and euphoria: Modification of agonist effects using buprenorphine. Presentation Transcript