Welcome Remarks and Overview of CTSI Resources


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Welcome Remarks and Overview of CTSI Resources
Steven Dubinett, MD
Director, UCLA Clinical and Translational Science Institute
President/CEO, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center

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  • Our CTSI proposes to create a collaborative culture in which practice-changing innovation is not the exception but the rule
  • Lisa confirmed these are the correct dates (Jessica)
  • Live now with diagnoses, procedures, demographics harmonized across the UC medical centers Issues with data: 1 year from UCSF, no peds at UCSD, 20 years at UCI Next year: Top 120 lab tests, microbiology, 4 medications needed for a surveillance project; harmonized honest broker and cohort recruitment process
  • Welcome Remarks and Overview of CTSI Resources

    1. 1. Steven Dubinett, MD Director, Clinical and Translational Science Institute Associate Vice Chancellor and Senior Associate Dean, Translational Research NIH/ Career Development Award Workshop July 25, 2013 1 UCLA CTSI Clinical and Translational Science Institute www.ctsi.ucla.edu
    2. 2. Create an academic home for translational science Advance team science Train the next generation of translational scientists Build bi-directional community partnerships Promote inter-institutional collaborations UCLA CTSI Goals 2
    3. 3. NIH CTSA Consortium
    4. 4. 4 UCLA translational investigation extends from molecules to society Translating knowledge gained from laboratory science into clinical practice to improve health. The aim of translational research is to produce new: • therapeutics • medical devices • tools for diagnosing disease • avenues for community engagement research What is translational research?
    5. 5. 5 1) Clinical and Community Research Resources (CCRR) 2) Biomedical Informatics Program (BIP) 3) Community Engagement in Research Program (CERP) 4) Pilot and Collaborative Translational and Clinical Studies Programs (Pilot) 5) Research Education, Training and Career Development Program (CTSI-ED) Program Areas (1-5)
    6. 6. 6 6) Biostatistics and Computational Biology Program 7) Center for Translational Technologies (CTT) 8) Maternal, Child and Adolescent Health (MCAH) 9) Regulatory Knowledge, Industry Relations and Research Ethics Program (Regulatory) 10) Evaluation & Tracking Program Areas (6-10)
    7. 7. 7 Opportunity Funds Grant Amount Duration of Award (Years) Award Cycle Application Due Date KL2 Awards: to pursue interdisciplinary, mentored research with training Up to $125,000 in salary and research support 1 year at 75% effort (renewable for up to 3 years) July 1 RFA to be released in Jan 2014 Full application: late Feb 2014 TL1 Translational Science Fellowship: PhD candidates in the Department of Health Policy and Management in the UCLA Fielding School of Public Health receive mentored training to ensure the translational nature of their dissertation projects Annual stipend plus funding for health insurance, tuition/fees, and training-related travel Renewable for up to 4 years Annual UCLA School of Public Health application deadline is Dec 1, 2014 TL1 Summer Program for Professional Students: provides professional students (medical, nursing and dental) early exposure to interdisciplinary, community-partnered translational or health services research Summer stipend plus funding for training-related expenses The summer between student’s first and second year (8 weeks) June 1 March 28, 2014 Early Career Awards
    8. 8. Assistant Professor, CDU “ Effects of Varenicline on Alcohol and Nicotine Consumption and changes in Dopamine D2-like Receptor Availability in High-Alcohol Preferring Mice” Amira Brown, MS, PhDAmira Brown, MS, PhD Assistant Professor, Pediatric Nephrology, UCLA “ Hepcidin and the Anemia of Chronic Kidney Disease” Joshua Zaritsky, MD, PhDJoshua Zaritsky, MD, PhD Assistant Professor of Medicine, UCLA/VA “ Patterns and Predictors of Poor Outcomes Following Emergency Department Discharge in Older Adults” Gelareh Gabayan, MD, MSHSGelareh Gabayan, MD, MSHS KL2 Y1 Awardees
    9. 9. 9 Assistant Professor, UCLA-Harbor / LA-BioMed “Using Research in Vancomycin-Resistant Enterococcus to Validate an Efficient System of Quantifying Antibiotic Utilization” James McKinnell, MDJames McKinnell, MD Assistant Professor, UCLA “Modeling of EMT/MET transitions in breast cancer stem cells” Mary Sehl, MD, PhDMary Sehl, MD, PhD Assistant Professor, UCLA “Development of novel therapeutic strategies to target LKB1/STK11 deficient non-small cell lung cancer” David Shackelford, PhDDavid Shackelford, PhD KL2 Y2 Awardees
    10. 10. 10 Assistant Professor, UCLA “Understanding the relationship between adolescent identity and substance use” Rebecca Dudovitz, MD, MSHSRebecca Dudovitz, MD, MSHS Assistant Clinical Professor, Cedars-Sinai Medical Center “Role of IL1-ß and the NLRP3 inflammasome in the development of hypoxemia in acute lung injury” Heather Jones, MDHeather Jones, MD Assistant Professor, UCLA “Single fraction vs. multiple fraction radiation for patients with advanced cancer and painful bone metastases” Anne Walling, MD, PhDAnne Walling, MD, PhD KL2 Y3 Awardees Clinical Instructor, UCLA “Mechanisms Of Allograft Injury And The Development Of Bronchiolitis Obliterans Syndrome After Lung Transplantation” Michael Shino, MDMichael Shino, MD
    11. 11. 11 Assistant Clinical Professor, UCLA “Relationship of physical activity to hippocampal structure and memory in MCI” David Merrill, MD, PhDDavid Merrill, MD, PhD Assistant Professor, UCLA “Gene expression profiles of ECT response in major depressive disorder” Eliza Congdon, PhDEliza Congdon, PhD Assistant Professor, Cedars-Sinai Medical Center “Minimizing errors in medication histories obtained at hospital admission” Joshua Pevnick, MD, MSHSJoshua Pevnick, MD, MSHS KL2 Y3 Awardees Assistant Professor, Charles Drew University of Medicine and Science “Sensitization of castration-resistant prostate tumors to docetaxel treatment by green tea and quercetin” Piwen Wang, MD, PhD, MSPiwen Wang, MD, PhD, MS
    12. 12. Ambulatory Clinical Research Facilities at Westwood •7 private rooms, infusion rooms, 2 procedure rooms •>20,000 sq ft outpatient area •Clinical and Research Sleep Center •Interview and conference rooms •Scatter Specialty Unit •Service center with pharmacy and sample processing •23 hour capacity CTSI-Wide Accomplishments •Clinical support for existing research projects •119 new protocols •8,137 out-patient & 744 in-patient stays across the CTSI •Implemented cost-sharing model with waivers or reduced rates for new investigators Clinical and Translational Research Center (CTRC)
    13. 13. Biostatistical Consults · Core Services · Pilot Funding · CTSI Activities 13banner “Cite It” card posters newsletters Quarterly publication awards Biostatistical Consults •1267 projects for 611 investigators Vouchers •Awarded 230 proposals ($2.2 M) Pilot funding •Awarded 195 pilot grants for total of $6.45 M ($3.65 M in CTSI funds; $2.8 M institutional funds) •Return of $26 M CTSI Activities • 20 proposals funded for total of $80 M ($88 M pending) • Rapid Response Team: supported 23 collaborations • Office of Investigator Services: 744 consults More than 430 publications prior to January 2013
    14. 14. University of California, Los Angeles CTSA Regional Consortia
    15. 15. 15 • A committee of the CTSA PIs at UC Davis, San Diego, San Francisco, Irvine and Los Angeles • Initial focus on contracting, informatics and IRBs • Drug discovery and development • Biobanking and global consent • Future inclusion of UCLA CTSI partner institutions including LA county health system UC Biomedical Research Acceleration Integration and Development (UC-BRAID)
    16. 16. 16banner “Cite It” card newsletters UCLA UC Davis UC San Francisco UC Irvine UC San Diego Los Angeles UCLA xData Repository · Los Angeles Data Repository · UC Research Exchange UC Research Exchange (UC-ReX) Los Angeles Data Repository (LADR) UCLA xData Repository (xDR)
    17. 17. 17 UC Research Exchange (UC-ReX) UC Biomedical Research Acceleration Integration and Development (UC-BRAID)
    18. 18. factsperdecision 5 Adapted from W. Stead et al, Academic Medicine, Vol. 84, No. 4 / April 2011 1990 2000 2010 2020 Clinical data Human cognitive capacity Genetics and proteomics 10 100 1000 Augmenting human cognitive capacity in translational research
    19. 19. imagingimaging pathologypathology activities of daily livingactivities of daily living clinical outcomesclinical outcomes DNADNA RNARNA epigeneticsepigenetics proteinsproteins computationalcomputational medicinemedicine universe ofuniverse of clinical dataclinical data computationalcomputational biologybiology symptomssymptoms clinical laboratoryclinical laboratory monitored datamonitored data A model of computational medicine behaviorsbehaviors
    20. 20. time prediction medicine data Investigations in Prediction Medicine population based evaluations Katzan and Rudick. Time to integrate clinical and research informatics. Science Transl Med 2012
    21. 21. UC Research Exchange (UC-ReX)UC Research Exchange (UC-ReX)