Advanced Development for Africa commissioned this report as the first in a series of special reports on Scaling Up Mobile Health to assess various implementations of mHealth programs in developing country contexts that were either scaled up or in the process of achieving this. The objective was to identify the important elements necessary for achieving scale. This report profiled select mHealth programs that had been piloted and were in the scale up phase, having proven enough success that they should be considered as potential models for other initiatives. Using the identified success factors and interviews with experts in the field of mHealth, the report generated a set of best practices and specific programmatic, operational, policy and global strategy recommendations to create an enabling environment for mHealth and support organizations in achieving scale. Interviewed experts included: Patricia Mechael, Executive Director of the mHealth Alliance; David Aylward, Senior Advisor on Global Health and Technology at Ashoka; Brooke Partridge, CEO of Vital Wave Consulting; Anne-Roos Weil, Co-Fonder and Managing Director of Pesinet; and Getachew Sahlu, eHealth Expert and Program Manager at the WHO. The primary goal of ADA’s first report is to provide recommendations and best practices that will allow mHealth initiatives to better plan their own scale up beyond successful pilot phases.