MitosisBiology is the onlysubject in whichmultiplication is thesame thing as division…
Where it all began…You started as a cell smaller thana period at the end of a sentence…
And now look at you!                 How did you                  get from                  there to                   here?
Mitosis!   The fertilized egg must divide…    and divide….      and divide….       and divide…
Why do cells divide… for reproduction      one celled organisms (clones)      asexual reproduction                     ...
Dividing cells… What has to be copied     DNA     organelles     cell membrane     lots of other      molecules      ...
Copying DNA A dividing cell duplicates its DNA     creates 2 copies of all DNA     sends the 2 copies to opposite ends ...
Organizing & packaging DNA into              chromosomes…DNA                          cell               nucleus          ...
Important  Vocabulary•DNA•Chromatin•Histone•Chromosomes/chromatid•Sister chromatid•Centromere
Structure of a Chromosome
Chromosome
Copying & packaging DNA  When cell is ready to divide…       copy DNA first, then…       coil up doubled chromosomes   ...
Copying DNA…                                           chromosomes in cell      DNA in chromosomes                        ...
double-strandedhuman chromosomesready for mitosis
Chromosomes of Human Female     46 chromosomes     23 pairs
Chromosomes of Human Male    46 chromosomes    23 pairs
Cell Cycle
Mitosis Vocabulary   Centrioles – small, cylinder shaped structures found near    the nucleus, involved in mitosis      ...
Interphase              DNA found as chromatin                              Cell grows & produces                       ...
Eukaryotic chromsome replicating
Prophase                                  Chromosomes become                                   visible                   ...
Metaphase               Spindle is fully developed               Sister chromatids line up                at the equator...
Anaphase      Sister chromatids               separate                  One complete set of                   chromosome...
Telophase  Chromosomes reach                opposite poles               Nuclear membrane and                nucleolus r...
CytokinesisDivision of the cytoplasm &organelles into two cells thatoccurs at the end of mitosis
New “daughter” cells Get 2 exact copies of original cells     same DNA     “clones”
REMEMBER!InterphaseProphaseMetaphase    IPMATAnaphaseTelophase
Mitosis in whitefish embryo
How does mitosis differ in plants?
How does mitosis differ in plants? Plant cells do not have centrioles Plant cells do not pinch in half Cytokinesis is a...
Overview of mitosisCopy DNA      Wind Up                                Bye-Bye! Line Up       Separate      Divide
onion root tip
Cell Turnover – the speed of          mitosis           The time it takes for a cell to            complete one cycle can...
Control of the Cell Cycle Growth & division are carefully regulated The protein cyclin regulates the cell cycle.     Cy...
How do we know? Scientists found that when cyclin is  injected into a nondividing cell, that cell  forms a spindle They ...
Other Regulatory Proteins Internal     Proteins in the cell respond to events inside      the cell       • E.g. makes su...
Other Regulatory Proteins External     Proteins that respond to events outside the      cell       • May stimulate growt...
Cancer – cell division gone wild!   Cancer – uncontrolled    mitosis       Don’t respond to normal        cellular contr...
Cancer – cell division gone wild! Tumor – a mass of abnormal cells     Benign tumor – abnormal cells remain in      orig...
Biology is the only subject inwhich multiplication is the same      thing as division…                            2006-2007
Copy of mitosis 2010
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Copy of mitosis 2010

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  • Unicellular organisms Cell division = reproduction Reproduces entire organism& increase population Multicellular organisms Cell division provides for growth & development in a multicellular organism that begins as a fertilized egg Also use cell division to repair & renew cells that die from normal wear & tear or accidents
  • DNA – deoxyribonucleic acid, the hereditary material of the cell. Chromatin – thin twisted strands of DNA wrapped around proteins How DNA is found in a nondividing cell Histones – proteins DNA is wrapped around in chromatin Chromosomes/chromatid – short, thick, condensed DNA/protein structures found in dividing cells Sister chromatids – double chromosome found during cell division Centromere – region that connects sister chromatids and where the spindle attaches to the chromatids
  • A mnemonic to help remember the stages of mitosis.
  • Transcript of "Copy of mitosis 2010"

    1. 1. MitosisBiology is the onlysubject in whichmultiplication is thesame thing as division…
    2. 2. Where it all began…You started as a cell smaller thana period at the end of a sentence…
    3. 3. And now look at you! How did you get from there to here?
    4. 4. Mitosis! The fertilized egg must divide… and divide…. and divide…. and divide…
    5. 5. Why do cells divide… for reproduction  one celled organisms (clones)  asexual reproduction amoeba for growth & development  from fertilized egg to multi-celled organism for repair starfish  replace cells that die from normal wear & tear or from injury
    6. 6. Dividing cells… What has to be copied  DNA  organelles  cell membrane  lots of other molecules • enzymes plant cell animal cell
    7. 7. Copying DNA A dividing cell duplicates its DNA  creates 2 copies of all DNA  sends the 2 copies to opposite ends of the cell  splits into 2 daughter cells  the DNA startsDNA loosely wound in cell the nucleus  If you tried to divide it like that, it could nucleus tangle & break
    8. 8. Organizing & packaging DNA into chromosomes…DNA cell nucleus DNA has been “wound up”DNA in chromosomes ineveryday “working” cell cell nucleus4 chromosomes DNA in chromosomes in cellin this organism getting ready to divide
    9. 9. Important Vocabulary•DNA•Chromatin•Histone•Chromosomes/chromatid•Sister chromatid•Centromere
    10. 10. Structure of a Chromosome
    11. 11. Chromosome
    12. 12. Copying & packaging DNA  When cell is ready to divide…  copy DNA first, then…  coil up doubled chromosomes like thread on a spool… • now can move DNA around cell without having it tangle & break Coil DNA intoCopying DNA compact chromosomes
    13. 13. Copying DNA… chromosomes in cell DNA in chromosomes cell 4 single-stranded chromosomes duplicated chromosomes nucleus duplicated chromosomes cell4 double-stranded chromosomes nucleus
    14. 14. double-strandedhuman chromosomesready for mitosis
    15. 15. Chromosomes of Human Female 46 chromosomes 23 pairs
    16. 16. Chromosomes of Human Male 46 chromosomes 23 pairs
    17. 17. Cell Cycle
    18. 18. Mitosis Vocabulary Centrioles – small, cylinder shaped structures found near the nucleus, involved in mitosis  Only in animal cells Aster – star like structure made of microtubules that extend from centrioles Spindle – web like structure made up of microtubule fibers. It arranges and moves the chromosomes around.
    19. 19. Interphase  DNA found as chromatin  Cell grows & produces more molecules & organelles  DNA and centrioles replicateDNA  Three mini stages:  G1 cell  S  G2 nucleus Interesting things happen!
    20. 20. Eukaryotic chromsome replicating
    21. 21. Prophase  Chromosomes become visible  DNA is wound into chromosomes  Nuclear membrane andduplicated nucleolus breakdownchromosomes  Centrioles move to opposite poles  Spindle and asters cell begins to form Chromosomes nucleus pair up!
    22. 22. Metaphase  Spindle is fully developed  Sister chromatids line up at the equator  Chromatids are attached to the spindle at the centromere Chromosomes meet in the middle!
    23. 23. Anaphase  Sister chromatids separate  One complete set of chromosomes goes to each pole  Spindle pull chromatids to opposite poles  Cytokinesis begins Chromosomes get pulled apart!
    24. 24. Telophase  Chromosomes reach opposite poles  Nuclear membrane and nucleolus reappear  Spindle disappears  Chromosomes unravel  Cytokinesis is completed Now there are two!
    25. 25. CytokinesisDivision of the cytoplasm &organelles into two cells thatoccurs at the end of mitosis
    26. 26. New “daughter” cells Get 2 exact copies of original cells  same DNA  “clones”
    27. 27. REMEMBER!InterphaseProphaseMetaphase IPMATAnaphaseTelophase
    28. 28. Mitosis in whitefish embryo
    29. 29. How does mitosis differ in plants?
    30. 30. How does mitosis differ in plants? Plant cells do not have centrioles Plant cells do not pinch in half Cytokinesis is accomplished through the formation of a cell plate between the two daughter cells
    31. 31. Overview of mitosisCopy DNA Wind Up Bye-Bye! Line Up Separate Divide
    32. 32. onion root tip
    33. 33. Cell Turnover – the speed of mitosis  The time it takes for a cell to complete one cycle can vary between a couple of minutes to days.  Cells that are continuously being worn away have a rapid turnover. E.g. skin, epithelial cells, RBC, etc.  Cells which make up organs such as the eye and the brain do not multiply very often if ever once they reach adult size.
    34. 34. Control of the Cell Cycle Growth & division are carefully regulated The protein cyclin regulates the cell cycle.  Cyclin is produced during interphase.  Once the cyclin reaches a certain level it triggers mitosis.  During mitosis most of the cyclin is destroyed.  The new daughter cells must produce new cyclin before a second mitosis can occur
    35. 35. How do we know? Scientists found that when cyclin is injected into a nondividing cell, that cell forms a spindle They then found the amount of cyclin increased and decreased in timing with the cell cycle
    36. 36. Other Regulatory Proteins Internal  Proteins in the cell respond to events inside the cell • E.g. makes sure cell does not enter mitosis until all chromosomes have been replicated • E.g. No anaphase until all chromosomes are attached to the spindle
    37. 37. Other Regulatory Proteins External  Proteins that respond to events outside the cell • May stimulate growth – e.g. wound healing, embryonic development • May slow growth – e.g. prevent excessive growth, keep tissues from disrupting each other
    38. 38. Cancer – cell division gone wild! Cancer – uncontrolled mitosis  Don’t respond to normal cellular controls  Cells divide excessively  Many causes resulting in gene mutations (often in gene p53) • Smoking, radiation, viral infection, heredity
    39. 39. Cancer – cell division gone wild! Tumor – a mass of abnormal cells  Benign tumor – abnormal cells remain in original location  Malignant tumor – abnormal cells leave the original site and impair the function of one or more organs
    40. 40. Biology is the only subject inwhich multiplication is the same thing as division… 2006-2007

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