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Hypertrophic Osteodystrophy
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Hypertrophic Osteodystrophy

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  • HOD and PANO are both associated with dysfunction in long bone development.  There is significant inflammation, edema and bone pain that can progress to deformity and bone necrosis.  

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  • 1. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE HISTORY: • In addition to the deformity evident in the clinical photo, this animal was lame and showed pain and warmth on palpation of the lower limb.
  • 2. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE LESION/S AND DESCRIPTION • calcification • Hemorrhage • Metaphyseal enlargement
  • 3. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Basic disease process/es • Inflammation • Necrosis
  • 4. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE DIAGNOSIS • Hypertrophic osteodystrphy
  • 5. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE
  • 6. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE
  • 7. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE BASIS/ BASES FOR THE DIAGNOSIS • History o Animal o Breed o Age o Specimen
  • 8. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Differential diagnosis and the reasons for such. • Panosteitis It is a self-limiting developmental disease of young, large and giant breeds of dogs resulting in pain, lameness in one or more limbs.
  • 9. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE • Hypertrophic Osteopathy (HO) It is a condition that affects long bones but is secondary to a primary thoracic or abdominal mass. The bony lesions are characterized by bilateral, symmetrical swellings affecting the distal extremities of the four limbs.
  • 10. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE • Etiological information The cause of HOD is currently unknown
  • 11. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Methods of transmission of the etiology and spread Genetic component is suspected.
  • 12. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Other lesions present in the other organs not shown in the picture metastatic calcification of the aorta, endocardium, lungs, and kidneys at necropsy.
  • 13. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Other lesions present in the other organs not shown in the picture metastatic calcification of the aorta, endocardium, lungs, and kidneys at necropsy.
  • 14. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Clinical signs • Anorexia • Depression • pyrexia • weight loss.
  • 15. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Clinical signs • Anorexia • Depression • pyrexia • weight loss.
  • 16. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE
  • 17. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Cause/s of death not necessarily euthanasia • Cardiac failure • Respiratory failure • Dehydration
  • 18. SPECIMEN: POST-MORTEM VIEW OF THE SAGITALLY-SPLIT DISTAL RADIUS OF A 3-MONTH OLD GREAT DANE Cause/s of death not necessarily euthanasia • Cardiac failure • Respiratory failure • Dehydration