Agents can participate with zero or near-zero cost (free hosted services – e.g. Google)
Self-organizing redundant processes
How radical openness can assist in the automation of science
UsefulChem Project: Open Primary Research in Drug Design using Web2.0 tools Docking Synthesis Testing Rajarshi Guha Indiana U JC Bradley Drexel U Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Tsu-Soo Tan Nanyang Inst.
Malaria Target: falcipain-2 involved in hemoglobin metabolism Dana.org
The Ugi reaction: can we predict precipitation? Can we predict solubility in organic solvents?
Open and Closed Science Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article Open Notebook Science (full transparency) CLOSED OPEN Traditional Paper Textbook F2F lectures Lectures Notes public Assigned problems public Archived Lectures Public and free online textbooks RESEARCH TEACHING
Outlier Bot: flags measurements with high standard deviation to mean ratios
Google Analytics queries – new solvent/solute searches
Solubility request form – researcher in Israel requesting pyrene in acetonitrile solubility for environmental soil contamination study
Application based models – high priority Ugi reactants
Solvent mixture and temperature: multidimensional solubility data Actual Data (4-nitrobenzaldehyde) From quadratic regression of 5D space Feeds DoSol Sheet the next points to measure to best cover the space