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Bradley Research Sept 2007
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Bradley Research Sept 2007

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A summary of the research work of Jean-Claude Bradley at Drexel University September 2007. A few slides on the CombiUgi project and malaria then some screenshots of the Open Notebook Science project …

A summary of the research work of Jean-Claude Bradley at Drexel University September 2007. A few slides on the CombiUgi project and malaria then some screenshots of the Open Notebook Science project UsefulChem.

Published in Technology , Health & Medicine
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  • 1. The synthesis of anti-malarial and anti-tumor agents using the Ugi Reaction Jean-Claude Bradley September 26, 2007 Research Mini-Symposium at Drexel University
  • 2. The Malaria Problem
    • Over 300 million people a year infected
    • Over 1 million deaths per year
    • Increasing resistance to existing drugs means there is a pressing need for new anti-malarial agents
  • 3. The Ugi Reaction Virtual library of 500K Ugi products
  • 4. Some Ugi products predicted to bind to malarial enzymes Enoyl reductase
  • 5. Falcipain-2
    • Breaks down hemoglobin
    • Collaboration with the Rosenthal group at UCSF
  • 6. Open Primary Research in Drug Design using Web2.0 tools (blogs, wikis, Second Life, mailing lists) Docking Synthesis Testing Rajarshi Guha Indiana U JC Bradley Drexel U Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Tsu-Soo Tan Nanyang Poly.
  • 7. Closing the Loop
  • 8.
    • Wired Magazine
    • Nature blogs
    • C&E News
    • Cell
    • Per Contra
    • Assignment Zero
    • NPR Marketplace
    • Chemistry Central
    • 3 Quarks Daily
    The UsefulChem Project and Open Notebook Science in the media
  • 9. The public wiki is the lab notebook Each Experiment on a Wiki Page
  • 10. Tracking Experiment Edits (advisor’s comments in bold/italics)
  • 11. Experiment History
  • 12. Monitoring experimental progress
  • 13. Third Party Time-Stamp on Experiment Versions
  • 14. Graphical Mining of Data with JSpecView usefulchem.wikispaces.com/Exp070 (48h 7 min)
  • 15. usefulchem.blogspot.com The blog as an integrative tool
  • 16. How are people finding our experiments?
  • 17. Molecules found by InChI
  • 18. Comments from peers
  • 19. Mailing List Facilitates inter-group collaboration
  • 20. Telling the story of the failures
  • 21. Mechanistic Studies of acid-catalyzed furfuryl group cleavage
  • 22. What is the role of the amide as a leaving group?
  • 23. Group present/past
    • Khalid Mirza
    • Rikesh Parikh
    • Mitesh Shah
    • Sean Gardner
    • Jessica Colditz
    • Dave Strumfels
    • James Giammarco