Open Notebook Science in Drug Discovery

Open Notebook Science in Drug Discovery Jean-Claude Bradley August 24, 2010 Drug Discovery: Easing the Bottleneck Associate Professor of Chemistry Drexel University Industry and Academia Panel

Can Open Science and Drug Discovery Mix?

Industry is Sharing More

Some Initiatives Promoting More Openness in Drug Discovery

Motivation: Faster Science, Better Science

TRUST PROOF

Open Primary Research in Drug Design using Web2.0 tools (blogs, wikis, Second Life, mailing lists) Docking Synthesis Testing Rajarshi Guha Indiana U JC Bradley Drexel U Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Tsu-Soo Tan Nanyang Inst.

Outcome of Guha-Bradley-Rosenthal collaboration

Opportunities for Competitive Collaboration

Crowdsourcing Solubility Data

ONS Challenge Judges

ONS Submeta Award Winners

Data provenance: From Wikipedia to…

… the lab notebook and raw data

General Transparent Solubility Prediction (Andrew Lang)

Integration of Multiple Web Services to Recommend Solvents for Reactions (Andrew Lang)

Integration into MyExperiment Workflows to Process Virtual Libraries of Compounds Peter Li (ChemTaverna)

The Intersection of Open Notebooks (Bradley/Todd) and IP implications Open Notebook could have blocked patent if done earlier

Conclusions
Open Science can play a role in Drug Discovery
Open Notebook Science can be a useful tool in this context

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Open Notebook Science in Drug Discovery

by Jean-Claude Bradley on Aug 24, 2010

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Open Notebook Science in Drug Discovery — Presentation Transcript