Noticias jhonm

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noticias biologia molecular

noticias biologia molecular

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  • 1. Mutation Rates in Cancer Cells StronglyLinked to How Chromatin Is Organized.AndMicrobiologists reveal how T. brucei’s key Ttulo dos noticiasproteins organize to replicate its mtDNA. Su nombre
  • 2. Medical utility Bibliography Mutation Rates inGenetics can meet normal Cancer Cells Stronglyand abnormal processes - MARTINEZ S, Lina María. Linked to Howin living organisms, Biología Molecular. 5 ed Medellín: UPB Fac. Medicina Chromatin Isunderstanding thisprocess will give us a Organizedbroad knowledge of, as - Microbiologists reveal how T.sick and why, and how to brucei’s key proteins organize to replicate its mtDNA, Published ondo some early intervention July 11, 2012 Universidad dein disease processes. This Massachusetts en Amherst.study with efforts toprevent the progression of - Mutation Rates in Cancer Cells Microbiologists revealdiseases that kill millions Strongly Linked to Howof people each year, an how T. brucei’s key Chromatin Is Organized.important aspect of these ScienceDaily (July 26, 2012). proteins organize tostudies is to try to cure replicate its mtDNAdiseases without affectingpeople who have them,avoiding side effects areoften worse than the verydisease. Jhon M. Cardona Betancur Medicine Student -III Semester. Universidad Pontificia Bolivariana Molecular Biology- August 6 2012
  • 3. Introduction ScienceDaily (July 26, 2012) Published on July 11, 2012 Mutation Rates in Universidad de Massachusetts en AmherstStudies to treat diseases Cancer Cells Strongly Microbiologists revealthat affect humans are Linked to How how T. brucei’s keymade on many fronts, Chromatin Is proteins organize tostudying conditions of the Organized. replicate its mtDNA.host, the environment, orconditions own the Cancer is perhaps the area For many years, parasiticorganism, these studies where more research is diseases have affectedfocus on the mechanisms done in this case, the thousands of people, andby which reproduction is investigation focuses on has tried to avoid and curegiven of the cells of these the organization of them with little success inmicroorganisms and the chromatin as cause of some areas of the world,way to block these mutations that ultimately one possible cause is thatprocesses. become cancer. the treatment can affect the host is looking for ways to work around this. Student observation: all work carried out in cancer will always be Student observation: Knowledge of welcome, but even if they are made the mechanisms used by so that the least possible impact to microorganisms to survive, gives patients and their quality of life. us tools to attack them more effectively and with less affectation to our health.
  • 4. IntroductionStudies to treat diseases that affecthumans are made on many fronts,studying conditions of the host, theenvironment, or conditions own theorganism, these studies focus on themechanisms by which reproduction isgiven of the cells of thesemicroorganisms and the way to blockthese processes conditions of the host investigations focused on: Environment conditions conditions of the microsorganism
  • 5. ScienceDaily (July 26, 2012)Mutation Rates in Cancer CellsStrongly Linked to HowChromatin Is Organized.Cancer is perhaps the area wheremore research is done in this case, theinvestigation focuses on theorganization of chromatin as cause ofmutations that ultimately becomecancer. Student observation: all work carried out in cancer will always be welcome, but even if they are made so that the least possible impact to patients and their quality of life
  • 6. Mutation Rates in Cancer Cells Strongly Linked to How Chromatin Is Organized.Disease in which the body produces abnormal cells derived from thetissues themselves. These are generally characterized by escapereproductive control that required their original function, losing itsoriginal capabilities, and over time, acquiring others that are not theirs,invading progressively and by different routes nearby organs, or evenremotely via the lymphatic or hematogenous
  • 7. Mutation Rates in Cancer Cells Strongly Linked to How Chromatin Is Organized.cells in their body has a length of onemeter in the same DNA. In order toproperly package all the DNA in the cellnucleus, to be mounted on a structurecalled "chromatin".To form chromatin, the nucleosomes arebound together by another histoneproteins called H1. H1 winds thenucleosomes together into a chromatinfiber that is about 30 nanometers indiameter. These chromatin fibers arelooped into a 300 nanometer coiledchromatin fiber, and these coiledchromatin fibers are then wound into 700nanometer condensed chromatin
  • 8. Mutation Rates in Cancer Cells Strongly Linked to How Chromatin Is Organized. Chromatin Euchromatin HeterochromatinChromatin Is transcriptionally inactivegenetically active in and is highly repetitive DNAinterface rolled out sequences, Constituent Optional Formed by DNA sequences Contains are not transcribed as sequences that sequences satellite located are transcribed in in the centromeres of some cell types. chromosomes.
  • 9. Mutation Rates in Cancer Cells Strongly Linked to How Chromatin Is Organized.ObservationThis study is based on existing information asthe basis of the human genome, also generatednew information that may be used by otherresearchers around the world for the benefit ofpatients with cancer, given the importance thatwe can learn more about the causes of cancer.But can also be used to understand some of thebasic problems of genetics, such as why someregions of the genome mutate faster than others.and you can do to prevent this.
  • 10. Published on July 11, 2012Universidad de Massachusetts en AmherstMicrobiologists reveal how T.brucei’s key proteins organize toreplicate its mtDNAFor many years, parasitic diseaseshave affected thousands of people, andhas tried to avoid and cure them withlittle success in some areas of theworld, one possible cause is that thetreatment can affect the host is lookingfor ways to work around this. Student observation: Knowledge of the mechanisms used by microorganisms to survive, gives us tools to attack them more effectively and with less affectation to our health.
  • 11. Microbiologists reveal how T. brucei’s key proteins organize to replicate its mtDNAHuman African trypanosomiasis, also knownas sleeping sickness is a parasitic diseasetransmitted by a vector. The parasites thatcause it are protozoa belonging to the genusTrypanosoma. Are transmitted to humans bythe bite of the tsetse fly (genus Glossina) hascontracted the infection of humans oranimals that harbor the parasitespathogenic to humansSleeping sickness occurs only in 36 sub-Saharan Africa where there are tsetse fliesthat can transmit it. People who are moreexposed to contact with the tsetse fly andtherefore to the disease are the rural peopleengaged in agriculture, fisheries, livestockor hunting.
  • 12. Microbiologists reveal how T. brucei’s key proteins organize to replicate its mtDNAThe cell structure is typical with all eukaryotic organelles,including the nucleus, mitochondria, endoplasmic reticulum,Golgi apparatus and so on. The main unusual features includea single large mitochondria with a condensed mitochondrialDNA structure Cicle of tripanosome brucei
  • 13. Microbiologists reveal how T. brucei’s key proteins organize to replicate its mtDNAImmunofluorescence experimentsfocused set to follow its desired path,known as the identification of mtDNA Matriz mitocondrialpolymerase (POLID). mitochondrial DNA Proteínas de mitochondrial Granule Ribosomal inner membrane intermembraneThey found a mechanism how this protein is spaceinvolved in kDNA replication. In response to outerchanges during kDNA replication cycle, membranePOLID redistributed, changing location ofthe mitochondrial matrix approachesconcentrated around the kDNA, anddynamically relocalizaba the withdrawal ofthe molecules of kDNA.
  • 14. Microbiologists reveal how T. brucei’s key proteins organize to replicate its mtDNAObservationKnowing the mechanism by whichmicroorganisms survive gives ustools to attack them in a moreselective, without using toxicsubstances that alter the health ofthe person concerned.The importance of this study is thatit can also improve control of otherparasitic type diseases.
  • 15. Medical utilityGenetics can meet normal andabnormal processes in livingorganisms, understanding this processwill give us a broad knowledge of, assick and why, and how to do someearly intervention in diseaseprocesses. This study with efforts toprevent the progression of diseasesthat kill millions of people each year, animportant aspect of these studies is totry to cure diseases without affectingpeople who have them, avoiding sideeffects are often worse than the verydisease.
  • 16. Medical utility The development of increasingly selective drugs for their site of action in the future allow more timely action on the affected organ or even more on the molecule defective
  • 17. Medical utilityThe studies conducted on the humangenome, deciphering every day but thetangle of questions there in front of theorigin and explanation of many pathologies.Also reoriented many studies are underway.
  • 18. Medical utility The medicine of the future must address problems even before they appear, making diagnosis by genes that have an individual. It could also have resources to intervene in the DNA in many ways one could be nanotechnology, which would allow damage repair and embed information in the dna of an individual.
  • 19. Bibliography- MARTINEZ S, Lina María. Biología Molecular. 5 ed Medellín: UPB Fac. Medicina. Pag 46- Mutation Rates in Cancer Cells Strongly Linked to How ChromatinIs Organized. ScienceDaily (July 26, 2012).- Microbiologists reveal how T. brucei’s key proteins organize toreplicate its mtDNA, Published on July 11, 2012 Universidad deMassachusetts en Amherst
  • 20. Science and life can not and must be separated.For me science gives a partial explanation of life.Mutation Rates in Cancer Cells Strongly Linked to How Chromatin Is OrganizedAs it is based on facts, experience andexperiments ... I agree that faith is essential tosucceed in life, but I do not accept your definitionof faith, the belief that there is life after death.In my opinion, all you need is faith the belief thatstriving to do the best we can we will come tosuccess, and success for our purposes, theimprovement of mankind today and the future, itis penalty to be achieved.Rosalind Franklin 1940