Antihistamines, Decongestants, Antitussives, and Expectorants Drugs Affecting the Respiratory System
Understanding the Common Cold <ul><li>Most caused by viral infection  (rhinovirus or influenza virus—the “flu”) </li></ul>
Understanding the Common Cold <ul><li>Virus invades tissues (mucosa) of upper respiratory tract, causing upper respiratory...
Understanding the Common Cold <ul><li>Irritation of nasal mucosa often triggers the sneeze reflex. </li></ul><ul><li>Mucos...
Treatment of the Common Cold <ul><li>Involves combined use of antihistamines, nasal decongestants, antitussives, and expec...
Instructors may want to use  EIC Image #83:  Upper Respiratory Tract
Treatment of the Common Cold <ul><li>Difficult to identify whether cause is viral or bacterial. </li></ul><ul><li>Treatmen...
Antihistamines <ul><li>Drugs that directly compete with histamine  for specific receptor sites. </li></ul><ul><li>Two hist...
Antihistamines <ul><li>H 2  Blockers or H 2  Antagonists </li></ul><ul><ul><li>Used to reduce gastric acid in PUD </li></u...
Antihistamines <ul><li>H 1  antagonists are commonly referred  to asantihistamines </li></ul><ul><li>Antihistamines have s...
Antihistamines: Mechanism of Action <ul><li>BLOCK action of histamine at the receptor sites </li></ul><ul><li>Compete with...
Antihistamines: Mechanism of Action <ul><li>The binding of H 1  blockers to the histamine receptors prevents the adverse c...
Antihistamines: Mechanism of Action <ul><li>More effective in preventing the actions of histamine rather than reversing th...
Histamine vs. Antihistamine Effects <ul><li>Cardiovascular (small blood vessels) </li></ul><ul><li>Histamine effects: </li...
Histamine vs. Antihistamine Effects <ul><li>Smooth Muscle (on exocrine glands) </li></ul><ul><li>Histamine effects: </li><...
Histamine vs. Antihistamine Effects <ul><li>Immune System  </li></ul><ul><li>(Release of substances commonly  associated w...
Antihistamines:  Other Effects <ul><li>Skin: </li></ul><ul><li>Block capillary permeability, wheal-and-flare formation, it...
Antihistamines:  Therapeutic Uses <ul><li>Management of: </li></ul><ul><li>Nasal allergies </li></ul><ul><li>Seasonal or p...
Antihistamines <ul><li>10 to 20% of general population is sensitive  to various environmental allergies. </li></ul><ul><li...
Antihistamines:  Therapeutic Uses <ul><li>Also used to relieve symptoms associated  with the common cold: </li></ul><ul><l...
Antihistamines:  Side effects <ul><li>Anticholinergic (drying) effects, most common: </li></ul><ul><ul><li>Dry mouth </li>...
Antihistamines:  Two Types <ul><li>Traditional  </li></ul><ul><li>or  </li></ul><ul><li>Nonsedating/Peripherally Acting </...
Antihistamines: <ul><li>Traditional </li></ul><ul><li>Older </li></ul><ul><li>Work both peripherally and centrally </li></...
Antihistamines: <ul><li>Nonsedating/Peripherally Acting </li></ul><ul><li>Developed to eliminate unwanted side effects,  m...
Nursing Implications: Antihistamines <ul><li>Gather data about the condition or allergic reaction that required treatment;...
Nursing Implications: Antihistamines <ul><li>Instruct patients to report excessive sedation, confusion, or hypotension. </...
Nursing Implications: Antihistamines <ul><li>Best tolerated when taken with meals—reduces GI upset. </li></ul><ul><li>If d...
Decongestants
Nasal Congestion <ul><li>Excessive nasal secretions </li></ul><ul><li>Inflamed and swollen nasal mucosa </li></ul><ul><li>...
Decongestants <ul><li>Two main types are used: </li></ul><ul><li>Adrenergics (largest group) </li></ul><ul><li>Corticoster...
Decongestants <ul><li>Two dosage forms: </li></ul><ul><li>Oral </li></ul><ul><li>Inhaled/topically applied to the nasal me...
Oral Decongestants <ul><li>Prolonged decongestant effects,  but delayed onset </li></ul><ul><li>Effect less potent than to...
Topical Nasal Decongestants <ul><li>Both adrenergics and steroids </li></ul><ul><li>Prompt onset </li></ul><ul><li>Potent ...
Topical Nasal Decongestants <ul><li>Adrenergics: </li></ul><ul><ul><li>ephedrine (Vicks) naphazoline (Privine) </li></ul><...
Nasal Decongestants:  Mechanism of Action <ul><li>Site of action:  blood vessels surrounding  nasal sinuses </li></ul><ul>...
Nasal Decongestants:  Mechanism of Action <ul><li>Site of action:  blood vessels surrounding  nasal sinuses </li></ul><ul>...
Nasal Decongestants:  Drug Effects <ul><li>Shrink engorged nasal mucous membranes </li></ul><ul><li>Relieve nasal stuffine...
Nasal Decongestants:  Therapeutic Uses <ul><li>Relief of nasal congestion associated with: </li></ul><ul><li>Acute or chro...
Nasal Decongestants:  Side Effects <ul><li>Adrenergics Steroids </li></ul><ul><li>nervousness local mucosal dryness  and i...
Nursing Implications:  Nasal Decongestants <ul><li>Decongestants may cause hypertension, palpitations, and CNS stimulation...
Nursing Implications: Decongestants <ul><li>Patients should avoid caffeine and caffeine-containing products. </li></ul><ul...
Antitussives
Cough Physiology <ul><li>Respiratory secretions and foreign objects are naturally removed by the  </li></ul><ul><li>cough ...
Two Basic Types of Cough  <ul><li>Productive Cough </li></ul><ul><ul><li>Congested, removes excessive secretions </li></ul...
Coughing <ul><li>Most of the time, coughing is beneficial </li></ul><ul><li>Removes excessive secretions </li></ul><ul><li...
Antitussives <ul><li>Drugs used to stop or reduce coughing </li></ul><ul><li>Opioid and nonopioid  (narcotic and non-narco...
Antitussives: Mechanism of Action <ul><li>Opioid </li></ul><ul><li>Suppress the cough reflex by direct action on the cough...
Antitussives: Mechanism of Action <ul><li>Nonopioid </li></ul><ul><li>Suppress the cough reflex by numbing the stretch rec...
Antitussives: Therapeutic Uses <ul><li>Used to stop the cough reflex when the cough is nonproductive and/or harmful </li><...
Antitussives: Side Effects <ul><li>Benzonatate </li></ul><ul><li>Dizziness, headache, sedation </li></ul><ul><li>Dextromet...
Nursing Implications:  Antitussive Agents <ul><li>Perform respiratory and cough assessment, and assess for allergies. </li...
Nursing Implications:  Antitussive Agents <ul><li>Report any of the following symptoms to the caregiver: </li></ul><ul><ul...
Expectorants
Expectorants <ul><li>Drugs that aid in the expectoration  (removal) of mucus </li></ul><ul><li>Reduce the viscosity of sec...
Expectorants: Mechanisms of Action <ul><li>Direct stimulation  </li></ul><ul><li>or </li></ul><ul><li>Reflex stimulation <...
Expectorants:  Mechanism of Action <ul><li>Direct stimulation: </li></ul><ul><li>The secretory glands are stimulated direc...
Expectorants:  Mechanism of Action <ul><li>Reflex stimulation: </li></ul><ul><li>Agent causes irritation of the GI tract. ...
Expectorants:  Drug Effects <ul><li>By loosening and thinning sputum and bronchial secretions, the tendency to cough is in...
Expectorants:  Therapeutic Uses <ul><li>Used for the relief of nonproductive coughs associated with: </li></ul><ul><li>Com...
Expectorants: Common Side Effects <ul><li>guaifenesin terpin hydrate </li></ul><ul><li>Nausea, vomiting Gastric upset </li...
Nursing Implications:  Expectorants <ul><li>Expectorants should be used with caution in the elderly, or those with asthma ...
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NurseReview.Org - Antihistamines (Clinical Pharmacology)

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Transcript of "NurseReview.Org - Antihistamines (Clinical Pharmacology)"

  1. 1. Antihistamines, Decongestants, Antitussives, and Expectorants Drugs Affecting the Respiratory System
  2. 2. Understanding the Common Cold <ul><li>Most caused by viral infection (rhinovirus or influenza virus—the “flu”) </li></ul>
  3. 3. Understanding the Common Cold <ul><li>Virus invades tissues (mucosa) of upper respiratory tract, causing upper respiratory infection (URI). </li></ul><ul><li>Excessive mucus production results from the inflammatory response to this invasion. </li></ul><ul><li>Fluid drips down the pharynx into the esophagus and lower respiratory tract, causing cold symptoms: sore throat, coughing, upset stomach. </li></ul>
  4. 4. Understanding the Common Cold <ul><li>Irritation of nasal mucosa often triggers the sneeze reflex. </li></ul><ul><li>Mucosal irritation also causes release of several inflammatory and vasoactive substances, dilating small blood vessels in the nasal sinuses and causing nasal congestion. </li></ul>
  5. 5. Treatment of the Common Cold <ul><li>Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants. </li></ul><ul><li>Treatment is SYMPTOMATIC only, not curative. </li></ul><ul><li>Symptomatic treatment does not eliminate the causative pathogen. </li></ul>
  6. 6. Instructors may want to use EIC Image #83: Upper Respiratory Tract
  7. 7. Treatment of the Common Cold <ul><li>Difficult to identify whether cause is viral or bacterial. </li></ul><ul><li>Treatment is “empiric therapy,” treating the most likely cause. </li></ul><ul><li>Antivirals and antibiotics may be used, but viral or bacterial cause may not be easily identified. </li></ul>
  8. 8. Antihistamines <ul><li>Drugs that directly compete with histamine for specific receptor sites. </li></ul><ul><li>Two histamine receptors: </li></ul><ul><ul><li>H 1 histamine-1 </li></ul></ul><ul><ul><li>H 2 histamine-2 </li></ul></ul>
  9. 9. Antihistamines <ul><li>H 2 Blockers or H 2 Antagonists </li></ul><ul><ul><li>Used to reduce gastric acid in PUD </li></ul></ul><ul><ul><li>Examples: cimetidine (Tagamet), ranitidine (Zantac), or famotidine (Pepcid) </li></ul></ul>
  10. 10. Antihistamines <ul><li>H 1 antagonists are commonly referred to asantihistamines </li></ul><ul><li>Antihistamines have several effects : </li></ul><ul><ul><li>Antihistaminic </li></ul></ul><ul><ul><li>Anticholinergic </li></ul></ul><ul><ul><li>Sedative </li></ul></ul>
  11. 11. Antihistamines: Mechanism of Action <ul><li>BLOCK action of histamine at the receptor sites </li></ul><ul><li>Compete with histamine for binding at unoccupied receptors. </li></ul><ul><li>CANNOT push histamine off the receptor if already bound. </li></ul>
  12. 12. Antihistamines: Mechanism of Action <ul><li>The binding of H 1 blockers to the histamine receptors prevents the adverse consequences of histamine stimulation: </li></ul><ul><ul><li>Vasodilation </li></ul></ul><ul><ul><li>Increased gastrointestinal and respiratory secretions </li></ul></ul><ul><ul><li>Increased capillary permeability </li></ul></ul>
  13. 13. Antihistamines: Mechanism of Action <ul><li>More effective in preventing the actions of histamine rather than reversing them </li></ul><ul><li>Should be given early in treatment, before all the histamine binds to the receptors </li></ul>
  14. 14. Histamine vs. Antihistamine Effects <ul><li>Cardiovascular (small blood vessels) </li></ul><ul><li>Histamine effects: </li></ul><ul><ul><li>Dilation and increased permeability (allowing substances to leak into tissues) </li></ul></ul><ul><li>Antihistamine effects: </li></ul><ul><ul><li>Prevent dilation of blood vessels </li></ul></ul><ul><ul><li>Prevent increased permeability </li></ul></ul>
  15. 15. Histamine vs. Antihistamine Effects <ul><li>Smooth Muscle (on exocrine glands) </li></ul><ul><li>Histamine effects: </li></ul><ul><ul><li>Stimulate salivary, gastric, lacrimal, and bronchial secretions </li></ul></ul><ul><li>Antihistamine effects: </li></ul><ul><ul><li>Prevent salivary, gastric, lacrimal, and bronchial secretions </li></ul></ul>
  16. 16. Histamine vs. Antihistamine Effects <ul><li>Immune System </li></ul><ul><li>(Release of substances commonly associated with allergic reactions) </li></ul><ul><li>Histamine effects: </li></ul><ul><ul><li>Mast cells release histamine and other substances, resulting in allergic reactions. </li></ul></ul><ul><li>Antihistamine effect: </li></ul><ul><ul><li>Binds to histamine receptors, thus preventing histamine from causing a response. </li></ul></ul>
  17. 17. Antihistamines: Other Effects <ul><li>Skin: </li></ul><ul><li>Block capillary permeability, wheal-and-flare formation, itching </li></ul><ul><li>Anticholinergic: </li></ul><ul><li>Drying effect that reduces nasal, salivary, and lacrimal gland secretions (runny nose, tearing, and itching eyes) </li></ul><ul><li>Sedative: </li></ul><ul><li>Some antihistamines cause drowsiness </li></ul>
  18. 18. Antihistamines: Therapeutic Uses <ul><li>Management of: </li></ul><ul><li>Nasal allergies </li></ul><ul><li>Seasonal or perennial allergic rhinitis (hay fever) </li></ul><ul><li>Allergic reactions </li></ul><ul><li>Motion sickness </li></ul><ul><li>Sleep disorders </li></ul>
  19. 19. Antihistamines <ul><li>10 to 20% of general population is sensitive to various environmental allergies. </li></ul><ul><li>Histamine-mediated disorders: </li></ul><ul><ul><li>Allergic rhinitis (hay fever, mold and dust allergies) </li></ul></ul><ul><ul><li>Anaphylaxis </li></ul></ul><ul><ul><li>Angioneurotic edema </li></ul></ul><ul><ul><li>Drug fevers </li></ul></ul><ul><ul><li>Insect bite reactions </li></ul></ul><ul><ul><li>Urticaria (itching) </li></ul></ul>
  20. 20. Antihistamines: Therapeutic Uses <ul><li>Also used to relieve symptoms associated with the common cold: </li></ul><ul><li>Sneezing, runny nose </li></ul><ul><li>Palliative treatment, not curative </li></ul>
  21. 21. Antihistamines: Side effects <ul><li>Anticholinergic (drying) effects, most common: </li></ul><ul><ul><li>Dry mouth </li></ul></ul><ul><ul><li>Difficulty urinating </li></ul></ul><ul><ul><li>Constipation </li></ul></ul><ul><ul><li>Changes in vision </li></ul></ul><ul><li>Drowsiness </li></ul><ul><ul><li>(Mild drowsiness to deep sleep) </li></ul></ul>
  22. 22. Antihistamines: Two Types <ul><li>Traditional </li></ul><ul><li>or </li></ul><ul><li>Nonsedating/Peripherally Acting </li></ul>
  23. 23. Antihistamines: <ul><li>Traditional </li></ul><ul><li>Older </li></ul><ul><li>Work both peripherally and centrally </li></ul><ul><li>Have anticholinergic effects, making them more effective than nonsedating agents in some cases </li></ul><ul><li>Examples: diphenhydramine (Benadryl) chlorpheniramine (Chlor-Trimeton) </li></ul>
  24. 24. Antihistamines: <ul><li>Nonsedating/Peripherally Acting </li></ul><ul><li>Developed to eliminate unwanted side effects, mainly sedation </li></ul><ul><li>Work peripherally to block the actions of histamine; thus, fewer CNS side effects </li></ul><ul><li>Longer duration of action (increases compliance) </li></ul><ul><li>Examples: fexofenadine (Allegra) loratadine (Claritin) </li></ul>
  25. 25. Nursing Implications: Antihistamines <ul><li>Gather data about the condition or allergic reaction that required treatment; also, assess for drug allergies. </li></ul><ul><li>Contraindicated in the presence of acute asthma attacks and lower respiratory diseases. </li></ul><ul><li>Use with caution in increased intraocular pressure, cardiac or renal disease, hypertension, asthma, COPD, peptic ulcer disease, BPH, or pregnancy. </li></ul>
  26. 26. Nursing Implications: Antihistamines <ul><li>Instruct patients to report excessive sedation, confusion, or hypotension. </li></ul><ul><li>Avoid driving or operating heavy machinery, and do not consume alcohol or other CNS depressants. </li></ul><ul><li>Do not take these medications with other prescribed or OTC medications without checking with prescriber. </li></ul>
  27. 27. Nursing Implications: Antihistamines <ul><li>Best tolerated when taken with meals—reduces GI upset. </li></ul><ul><li>If dry mouth occurs, teach patient to perform frequent mouth care, chew gum, or suck on hard candy (preferably sugarless) to ease discomfort. </li></ul><ul><li>Monitor for intended therapeutic effects. </li></ul>
  28. 28. Decongestants
  29. 29. Nasal Congestion <ul><li>Excessive nasal secretions </li></ul><ul><li>Inflamed and swollen nasal mucosa </li></ul><ul><li>Primary causes: </li></ul><ul><ul><li>Allergies </li></ul></ul><ul><ul><li>Upper respiratory infections (common cold) </li></ul></ul>
  30. 30. Decongestants <ul><li>Two main types are used: </li></ul><ul><li>Adrenergics (largest group) </li></ul><ul><li>Corticosteroids </li></ul>
  31. 31. Decongestants <ul><li>Two dosage forms: </li></ul><ul><li>Oral </li></ul><ul><li>Inhaled/topically applied to the nasal membranes </li></ul>
  32. 32. Oral Decongestants <ul><li>Prolonged decongestant effects, but delayed onset </li></ul><ul><li>Effect less potent than topical </li></ul><ul><li>No rebound congestion </li></ul><ul><li>Exclusively adrenergics </li></ul><ul><li>Examples: phenylephrine pseudoephedrine (Sudafed) </li></ul>
  33. 33. Topical Nasal Decongestants <ul><li>Both adrenergics and steroids </li></ul><ul><li>Prompt onset </li></ul><ul><li>Potent </li></ul><ul><li>Sustained use over several days causes rebound congestion, making the condition worse </li></ul>
  34. 34. Topical Nasal Decongestants <ul><li>Adrenergics: </li></ul><ul><ul><li>ephedrine (Vicks) naphazoline (Privine) </li></ul></ul><ul><ul><li>oxymetazoline (Afrin) phenylephrine (Neo Synephrine) </li></ul></ul><ul><li>Intranasal Steroids: </li></ul><ul><ul><li>beclomethasone dipropionate (Beconase, Vancenase) </li></ul></ul><ul><ul><li>flunisolide (Nasalide) </li></ul></ul>
  35. 35. Nasal Decongestants: Mechanism of Action <ul><li>Site of action: blood vessels surrounding nasal sinuses </li></ul><ul><li>Adrenergics </li></ul><ul><ul><li>Constrict small blood vessels that supply URI structures </li></ul></ul><ul><ul><li>As a result, these tissues shrink and nasal secretions in the swollen mucous membranes are better able to drain </li></ul></ul><ul><ul><li>Nasal stuffiness is relieved </li></ul></ul>
  36. 36. Nasal Decongestants: Mechanism of Action <ul><li>Site of action: blood vessels surrounding nasal sinuses </li></ul><ul><li>Nasal steroids </li></ul><ul><ul><li>Anti-inflammatory effect </li></ul></ul><ul><ul><li>Work to turn off the immune system cells involved in the inflammatory response </li></ul></ul><ul><ul><li>Decreased inflammation results in decreased congestion </li></ul></ul><ul><ul><li>Nasal stuffiness is relieved </li></ul></ul>
  37. 37. Nasal Decongestants: Drug Effects <ul><li>Shrink engorged nasal mucous membranes </li></ul><ul><li>Relieve nasal stuffiness </li></ul>
  38. 38. Nasal Decongestants: Therapeutic Uses <ul><li>Relief of nasal congestion associated with: </li></ul><ul><li>Acute or chronic rhinitis </li></ul><ul><li>Common cold </li></ul><ul><li>Sinusitis </li></ul><ul><li>Hay fever </li></ul><ul><li>Other allergies </li></ul><ul><li>May also be used to reduce swelling of the nasal passage and facilitate visualization of the nasal/pharyngeal membranes before surgery or diagnostic procedures. </li></ul>
  39. 39. Nasal Decongestants: Side Effects <ul><li>Adrenergics Steroids </li></ul><ul><li>nervousness local mucosal dryness and irritation </li></ul><ul><li>insomnia </li></ul><ul><li>palpitations </li></ul><ul><li>tremors </li></ul><ul><li>(systemic effects due to adrenergic stimulation of the heart, blood vessels, and CNS) </li></ul>
  40. 40. Nursing Implications: Nasal Decongestants <ul><li>Decongestants may cause hypertension, palpitations, and CNS stimulation—avoid in patients with these conditions. </li></ul><ul><li>Assess for drug allergies. </li></ul>
  41. 41. Nursing Implications: Decongestants <ul><li>Patients should avoid caffeine and caffeine-containing products. </li></ul><ul><li>Report a fever, cough, or other symptoms lasting longer than a week. </li></ul><ul><li>Monitor for intended therapeutic effects. </li></ul>
  42. 42. Antitussives
  43. 43. Cough Physiology <ul><li>Respiratory secretions and foreign objects are naturally removed by the </li></ul><ul><li>cough reflex </li></ul><ul><ul><li>Induces coughing and expectoration </li></ul></ul><ul><ul><li>Initiated by irritation of sensory receptors in the respiratory tract </li></ul></ul>
  44. 44. Two Basic Types of Cough <ul><li>Productive Cough </li></ul><ul><ul><li>Congested, removes excessive secretions </li></ul></ul><ul><li>Nonproductive Cough </li></ul><ul><ul><li>Dry cough </li></ul></ul>
  45. 45. Coughing <ul><li>Most of the time, coughing is beneficial </li></ul><ul><li>Removes excessive secretions </li></ul><ul><li>Removes potentially harmful foreign substances </li></ul><ul><li>In some situations, coughing can be harmful, such as after hernia repair surgery </li></ul>
  46. 46. Antitussives <ul><li>Drugs used to stop or reduce coughing </li></ul><ul><li>Opioid and nonopioid (narcotic and non-narcotic) </li></ul><ul><li>Used only for NONPRODUCTIVE coughs! </li></ul>
  47. 47. Antitussives: Mechanism of Action <ul><li>Opioid </li></ul><ul><li>Suppress the cough reflex by direct action on the cough center in the medulla. </li></ul><ul><li>Examples: codeine (Robitussin A-C, Dimetane-DC) hydrocodone </li></ul>
  48. 48. Antitussives: Mechanism of Action <ul><li>Nonopioid </li></ul><ul><li>Suppress the cough reflex by numbing the stretch receptors in the respiratory tract and preventing the cough reflex from being stimulated. </li></ul><ul><li>Examples: benzonatate (Tessalon) dextromethorphan (Vicks Formula 44, Robitussin-DM) </li></ul>
  49. 49. Antitussives: Therapeutic Uses <ul><li>Used to stop the cough reflex when the cough is nonproductive and/or harmful </li></ul>
  50. 50. Antitussives: Side Effects <ul><li>Benzonatate </li></ul><ul><li>Dizziness, headache, sedation </li></ul><ul><li>Dextromethorphan </li></ul><ul><li>Dizziness, drowsiness, nausea </li></ul><ul><li>Opioids </li></ul><ul><li>Sedation, nausea, vomiting, lightheadedness, constipation </li></ul>
  51. 51. Nursing Implications: Antitussive Agents <ul><li>Perform respiratory and cough assessment, and assess for allergies. </li></ul><ul><li>Instruct patients to avoid driving or operating heavy equipment due to possible sedation, drowsiness, or dizziness. </li></ul><ul><li>If taking chewable tablets or lozenges, do not drink liquids for 30 to 35 minutes afterward. </li></ul>
  52. 52. Nursing Implications: Antitussive Agents <ul><li>Report any of the following symptoms to the caregiver: </li></ul><ul><ul><li>Cough that lasts more than a week </li></ul></ul><ul><ul><li>A persistent headache </li></ul></ul><ul><ul><li>Fever </li></ul></ul><ul><ul><li>Rash </li></ul></ul><ul><li>Antitussive agents are for NONPRODUCTIVE coughs. </li></ul><ul><li>Monitor for intended therapeutic effects. </li></ul>
  53. 53. Expectorants
  54. 54. Expectorants <ul><li>Drugs that aid in the expectoration (removal) of mucus </li></ul><ul><li>Reduce the viscosity of secretions </li></ul><ul><li>Disintegrate and thin secretions </li></ul>
  55. 55. Expectorants: Mechanisms of Action <ul><li>Direct stimulation </li></ul><ul><li>or </li></ul><ul><li>Reflex stimulation </li></ul><ul><li>Final result: thinner mucus that is easier to remove </li></ul>
  56. 56. Expectorants: Mechanism of Action <ul><li>Direct stimulation: </li></ul><ul><li>The secretory glands are stimulated directly to increase their production of respiratory tract fluids. </li></ul><ul><li>Examples: terpin hydrate, iodine-containing products such as iodinated glycerol and potassium iodide (direct and indirect stimulation) </li></ul>
  57. 57. Expectorants: Mechanism of Action <ul><li>Reflex stimulation: </li></ul><ul><li>Agent causes irritation of the GI tract. </li></ul><ul><li>Loosening and thinning of respiratory tract secretions occur in response to this irritation. </li></ul><ul><li>Examples: guaifenesin, syrup of ipecac </li></ul>
  58. 58. Expectorants: Drug Effects <ul><li>By loosening and thinning sputum and bronchial secretions, the tendency to cough is indirectly diminished. </li></ul>
  59. 59. Expectorants: Therapeutic Uses <ul><li>Used for the relief of nonproductive coughs associated with: </li></ul><ul><li>Common cold Pertussis </li></ul><ul><li>Bronchitis Influenza </li></ul><ul><li>Laryngitis Measles </li></ul><ul><li>Pharyngitis </li></ul><ul><li>Coughs caused by chronic paranasal sinusitis </li></ul>
  60. 60. Expectorants: Common Side Effects <ul><li>guaifenesin terpin hydrate </li></ul><ul><li>Nausea, vomiting Gastric upset </li></ul><ul><li>Gastric irritation (Elixir has high alcohol content) </li></ul>
  61. 61. Nursing Implications: Expectorants <ul><li>Expectorants should be used with caution in the elderly, or those with asthma or respiratory insufficiency. </li></ul><ul><li>Patients taking expectorants should receive more fluids, if permitted, to help loosen and liquefy secretions. </li></ul><ul><li>Report a fever, cough, or other symptoms lasting longer than a week. </li></ul><ul><li>Monitor for intended therapeutic effects. </li></ul>

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