Forensic ppt methyl alcohol

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Methyl Alcohol Poisoning

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Forensic ppt methyl alcohol

  1. 1. Introduction:  Also known as wood alcohol  Colorless, volatile liquid, odour similar to alcohol, burning taste.
  2. 2. Methyl Alcohol Dr.J.A.Dabhi Resident S.B.K.S.M.I.R.C Gujarat
  3. 3. Site of absorption o Skin o GIT o Lungs
  4. 4. Metabolism: Methanol Formaldehyde Formic Acid Metabolic Acidosis
  5. 5.  Formaldehyde 33 times more toxic than methanol.  Formic Acid is 6 times more toxic than methanol.
  6. 6.  Renal Toxicity  Distributed in the tissues having high water content, high conc. Is found in vitreous body and optic nerve, hence causes optic neuritis.
  7. 7. Elimination  About 80% excreted unchanged from lungs.  3-5% excreted unchanged in urine
  8. 8. Signs/Symptoms  Produces symptoms of drunkenness like ethyl alcohol.  Effects are more prolonged.  Appearance of symptoms: 1 hour – 24 hours
  9. 9.  General signs of poisoning  Odour present in breath.  Effects on CNS is well marked  Delirium, coma may last for 2-3 days  Toxic effects on liver, kidney and nervous system.
  10. 10.  Urine is strongly acidic and contain acetone and trace of albumin.  Metabolic acidosis: Due to excess of lactic acid and respiratory depression
  11. 11.  Pupils: Dilated and fixed  Photophobia, blurred vision  Central & peripheral scotoma  Decreased light perception  Sudden loss of vision or complete blindness due to optic neuritis may occur.
  12. 12.  Retinal ganglion cells and optic disc shows degenerative changes.  In fatal cases: Convulsions  Death may occur from respiratory depression
  13. 13.  Fatal Dose: 60-120 ml  Fatal Period: 24-36 hours or can be delayed for 2-4 days
  14. 14. Cause of death:  Death is mainly due to metabolic acidosis resulting from production of organic acids mainly, Formic Acid.  CNS depression leading to respiratory depression.
  15. 15. Treatment  Gastric lavage: 5% Sod.Bic  Ethyl Alcohol 50% 1ml/kg i.v. every 2 hours for 5 days.  Maintain blood alcohol level of 100-150 mg%
  16. 16. Methyl Alcohol Ethyl Alcohol Catalase Unchanged Methanol Excretion Acetaldehyde
  17. 17.  Haemodialysis is the treatment of choice.  Folic acid: 50-75 mg/ 4 Hrs increases elimination of formic acid.  Dextrose, Vit.B1, phosphate
  18. 18.  Maintain serum electrolyte to optimum level.  Head low position.  Keep airways clear.
  19. 19. Post-mortem Appearance  Marked cyanosis  Ab of PM clotting of blood  Purple color due to pyridine  Liver: fatty changes  Kidney: tubular necrosis
  20. 20. Circumstances  Accidently.  Non availability of beverages containing ethyl alcohol.

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