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Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
Forensic ppt methyl alcohol
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Forensic ppt methyl alcohol

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Methyl Alcohol Poisoning

Methyl Alcohol Poisoning

Published in: Health & Medicine
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  • 1. Introduction:  Also known as wood alcohol  Colorless, volatile liquid, odour similar to alcohol, burning taste.
  • 2. Methyl Alcohol Dr.J.A.Dabhi Resident S.B.K.S.M.I.R.C Gujarat
  • 3. Site of absorption o Skin o GIT o Lungs
  • 4. Metabolism: Methanol Formaldehyde Formic Acid Metabolic Acidosis
  • 5.  Formaldehyde 33 times more toxic than methanol.  Formic Acid is 6 times more toxic than methanol.
  • 6.  Renal Toxicity  Distributed in the tissues having high water content, high conc. Is found in vitreous body and optic nerve, hence causes optic neuritis.
  • 7. Elimination  About 80% excreted unchanged from lungs.  3-5% excreted unchanged in urine
  • 8. Signs/Symptoms  Produces symptoms of drunkenness like ethyl alcohol.  Effects are more prolonged.  Appearance of symptoms: 1 hour – 24 hours
  • 9.  General signs of poisoning  Odour present in breath.  Effects on CNS is well marked  Delirium, coma may last for 2-3 days  Toxic effects on liver, kidney and nervous system.
  • 10.  Urine is strongly acidic and contain acetone and trace of albumin.  Metabolic acidosis: Due to excess of lactic acid and respiratory depression
  • 11.  Pupils: Dilated and fixed  Photophobia, blurred vision  Central & peripheral scotoma  Decreased light perception  Sudden loss of vision or complete blindness due to optic neuritis may occur.
  • 12.  Retinal ganglion cells and optic disc shows degenerative changes.  In fatal cases: Convulsions  Death may occur from respiratory depression
  • 13.  Fatal Dose: 60-120 ml  Fatal Period: 24-36 hours or can be delayed for 2-4 days
  • 14. Cause of death:  Death is mainly due to metabolic acidosis resulting from production of organic acids mainly, Formic Acid.  CNS depression leading to respiratory depression.
  • 15. Treatment  Gastric lavage: 5% Sod.Bic  Ethyl Alcohol 50% 1ml/kg i.v. every 2 hours for 5 days.  Maintain blood alcohol level of 100-150 mg%
  • 16. Methyl Alcohol Ethyl Alcohol Catalase Unchanged Methanol Excretion Acetaldehyde
  • 17.  Haemodialysis is the treatment of choice.  Folic acid: 50-75 mg/ 4 Hrs increases elimination of formic acid.  Dextrose, Vit.B1, phosphate
  • 18.  Maintain serum electrolyte to optimum level.  Head low position.  Keep airways clear.
  • 19. Post-mortem Appearance  Marked cyanosis  Ab of PM clotting of blood  Purple color due to pyridine  Liver: fatty changes  Kidney: tubular necrosis
  • 20. Circumstances  Accidently.  Non availability of beverages containing ethyl alcohol.

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