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Genetics of human blood groups
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  • 1. Human Blood Groups
  • 2. ABO Blood Group
    • There are 4 blood types in ABO blood group system.
    Blood Group Antigen A A B B AB A and B O Nil
  • 3. Inheritance of Blood types
    • Human blood type is determined by co-dominant alleles.
    • There are three different alleles.
    • I A , I B and i
    • I A and I B are the dominant alleles and ‘ i ’ is the recessive allele.
      • Allele is one of the variant forms of a gene at a particular location, on a chromosome.
      • In an individual, one form of the allele (the dominant one) may be expressed more than another form (the recessive one).
  • 4. Role of alleles
    • I A produces A antigen
    • I B produces B antigen
    • i produces no antigen (recessive allele)
    • I A and I B are co-dominant. That is, an individual with the genotype I A I B will produce both A and B antigens
  • 5. Each of us has two blood type alleles. We inherit one blood type allele from our biological mother and one from our biological father. Genotype Blood Group A A B B AB O I A I A I A i I B I B I B i I A I B i i