Presentation of bio-chemistry <ul><li>Topic   </li></ul><ul><li>β -OXIDATION OF FATTY ACIDS  </li></ul><ul><li>Submitted t...
β -OXIDATION OF FATTY ACIDS INVOLVES SUCCESSIVE CLEAVAGE WITH RELEASE OF ACETYL-CoA <ul><li>In β-oxidation, two carbons at...
<ul><li>  </li></ul>
The Cyclic Reaction Sequence Generates FADH2 & NADH <ul><li>Several enzymes, known collectively as “fatty acid oxidase,” a...
 
Oxidation of a Fatty Acid With an Odd Number of Carbon Atoms Yields Acetyl CoA Plus a Molecule of Propionyl-CoA <ul><li>Fa...
Peroxisomes Oxidize Very Long Chain Fatty Acids <ul><li>A modified form of β-oxidation is found in peroxisomes and leads t...
OXIDATION OF UNSATURATED FATTY ACIDS OCCURS BY A MODIFIED β-OXIDATION PATHWAY
 
<ul><li>Thanks ………………………….. </li></ul>
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Presentation of bio chemistry

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Presentation of bio chemistry

  1. 1. Presentation of bio-chemistry <ul><li>Topic </li></ul><ul><li>β -OXIDATION OF FATTY ACIDS </li></ul><ul><li>Submitted to:- Submitted by:- </li></ul><ul><li>Dr.Zia Ur Rehman Simranjeet kaur </li></ul><ul><li>B-Pharmacy(5th sem) </li></ul>
  2. 2. β -OXIDATION OF FATTY ACIDS INVOLVES SUCCESSIVE CLEAVAGE WITH RELEASE OF ACETYL-CoA <ul><li>In β-oxidation, two carbons at a time are cleaved from acyl-CoA molecules, starting at the carboxyl end. </li></ul><ul><li>The chain is broken between the α(2)- and β(3)-carbon atoms—hence the name β-oxidation. </li></ul><ul><li>The two-carbon units formed are acetyl-CoA; thus, palmitoyl- CoA forms eight acetyl-CoA molecules. </li></ul>
  3. 3. <ul><li>  </li></ul>
  4. 4. The Cyclic Reaction Sequence Generates FADH2 & NADH <ul><li>Several enzymes, known collectively as “fatty acid oxidase,” are found in the mitochondrial matrix or inner membrane adjacent to the respiratory chain. </li></ul><ul><li>These catalyze the oxidation of acyl-CoA to acetyl-CoA, the system being coupled with the phosphorylation of ADP to ATP. </li></ul>
  5. 6. Oxidation of a Fatty Acid With an Odd Number of Carbon Atoms Yields Acetyl CoA Plus a Molecule of Propionyl-CoA <ul><li>Fatty acids with an odd number of carbon atoms are oxidized by the pathway of β-oxidation, producing acetyl-CoA, until a three-carbon (propionyl-CoA) residue remains. </li></ul><ul><li>This compound is converted to succinyl-CoA, a constituent of the citric acid cycle. </li></ul><ul><li>Hence, the propionyl residue from an odd-chain fatty acid is the only part of a fatty acid that is glucogenic </li></ul>
  6. 7. Peroxisomes Oxidize Very Long Chain Fatty Acids <ul><li>A modified form of β-oxidation is found in peroxisomes and leads to the formation of acetyl-CoA and H 2 O 2 (from the flavoprotein-linked dehydrogenase step), which is broken down by catalase. </li></ul><ul><li>  </li></ul>
  7. 8. OXIDATION OF UNSATURATED FATTY ACIDS OCCURS BY A MODIFIED β-OXIDATION PATHWAY
  8. 10. <ul><li>Thanks ………………………….. </li></ul>
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