Infrastructure services (Infrastructure-as-a-service), provided by cloud vendors, allow any user to provision a large number of compute instances fairly easily. Whether leased from public clouds or allocated from private clouds, utilizing these virtual resources to perform data/compute intensive analyses requires employing different parallel runtimes to implement such applications. Among many parallelizable problems, most “pleasingly parallel” applications can be performed using MapReduce technologies such as Hadoop, CGL-MapReduce, and Dryad, in a fairly easy manner. However, many scientific applications, which have complex communication patterns, still require low latency communication mechanisms and rich set of communication constructs offered by runtimes such as MPI. In this paper, we first discuss large scale data analysis using different MapReduce implementations and then, we present a performance analysis of high performance parallel applications on virtualized resources.