FLOATING TABLETS

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This ppt will give u information about the floating tablets & it's use in epilepsy.........

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FLOATING TABLETS

  1. 1. DEFINATION: Epilepsy is a disorder in which there is a tendency for the occurance of epileptic seizures.CAUSES: 1.Ideopathic: Cause unknown 2.Symptomatic:       Trauma, metabolic disorders
  2. 2.  Partial Seizures   1. Simple     2. Complex Generalized seizures 1.Tonic-clonic 2. MyoclonicGeneralized epilepsy   1. Benign neonatal convulsion   2. Childhood absence  
  3. 3.  DRUGS USED IN EPILEPSY: BARBITURATES:         1. PHENOBARBITAL VALPROIC ACID OTHER AGENTS  A. FELBATOL (FELBAMATE)  B. NEURONTIN (GABAPENTIN) FLOATING TABLETS: EFFERVACENT NONEFFERVACENT
  4. 4. Oral route is the most preferred routeof drug administration.Good patient compliance.Most of the drugs exhibit site specificabsorption in GITFloating drug delivery system is one ofthe very good approach for controlledrelease of the drug
  5. 5.  MATERIALS:  EQUIPMENTS GABAPENTEIN  ELECTRONIC HPMC BALANCE GUARGUM  PUNCHING Na BICARBONATE MACHINE TARTARIC ACID  HARDNESS TESTER Mg STERATE  VERNIER CALIPERS TALC DISSOLUTION NINHYDRIN APPARATUS
  6. 6. EXPERIMENTAL:  DRUG (GABAPENTEIN) MIXED IN BLENDOR PREPARATION OF GRANULES PASSED THROUGH SIEVE NO 18 DRIED IN PROCESSOR GRANULES ARE COMPRESSED TO TABLETS EVALUATION OF TABLETS
  7. 7. Floating lag timeDuration of floatingDimensional stabilityWater uptake studyIn vitro dissolutionRelease kinetics: Zero – order release kinetics: First– order release kinetics: Higuchi (Diffusion) equation: Q = k2t1/2

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