Cefuroxime axetil is a broad-spectrum cephalosporin antibiotic used orally to treat bacterial infections like pneumonia, bronchitis, ear infections, and skin infections. It is absorbed and broken down into the active form cefuroxime. Common side effects include diarrhea, abdominal pain, rash, and headache. Pseudomembranous colitis has been associated with cefuroxime axetil use and other broad-spectrum antibiotics, so its diagnosis should be considered in patients who develop diarrhea after use. Multiple pharmaceutical companies in Bangladesh produce and market various cefuroxime axetil formulations, with prices varying between different manufacturers.

1. SWOT Analysis of
cefuroxime axetil
Md: Jabiur Rahaman
Daffodil International
University,Bangladesh
Dept. of Pharmacy

2. Introduction
CEFTIN (cefuroxime axetil) Tablets and
CEFTIN (cefuroxime axetil) for Oral
Suspension contain cefuroxime as
cefuroxime axetil. CEFTIN (cefuroxime
axetil) is a semisynthetic, broad-spectrum
cephalosporin antibiotic for oral
administration.
Its molecular formula is C20H22N4O10S, and
it has a molecular weight of 510.48.

3. Cefuroxime axetil is in the amorphous form
and has the following structural formula:

4. CEFTIN (cefuroxime axetil) Tablets are film-
coated and contain the equivalent of 250 or
500 mg of cefuroxime as cefuroxime axetil.
CEFTIN (cefuroxime axetil) Tablets contain
the inactive ingredients colloidal silicon
dioxide, croscarmellose sodium,
hydrogenated vegetable oil, hypromellose,
methylparaben, microcrystalline cellulose,
propylene glycol, propylparaben, sodium
benzoate, sodium lauryl sulfate, and
titanium dioxide.

5. Strength
Cefuroxime Axetil - Clinical Pharmacology:
• Absorption and Metabolism: After oral administration,
Cefuroxime Axetil is absorbed from the gastrointestinal
tract and rapidly hydrolyzed by nonspecific esterases in
the intestinal mucosa and blood to cefuroxime.
Cefuroxime is subsequently distributed throughout the
extracellular fluids. The axetil moiety is metabolized to
acetaldehyde and acetic acid.
• Indications and Usage for Cefuroxime Axetil:
• Pharyngitis/Tonsillitis: caused byStreptococcus
pyogenes.
• Acute Bacterial Otitis Media: caused byStreptococcus
pneumoniae,Haemophilus influenzae(including beta-
lactamase–producing strains),Moraxella
catarrhalis(including beta-lactamase–producing strains),
orStreptococcus pyogenes.

6. • Acute Bacterial Maxillary Sinusitis: caused
byStreptococcus pneumoniaeorHaemophilus
• Acute Bacterial Exacerbations of Chronic Bronchitis
and Secondary BacterialInfections of Acute
Bronchitis: caused byStreptococcus
pneumoniae,Haemophilus influenza.
• Uncomplicated Skin and Skin-Structure Infections:
caused byStaphylococcus aureus(including beta-
lactamase–producing strains) orStreptococcus
pyogenes.

7. Pregnancy: Category B. The safety of
cefuroxime axetil in pregnancy has not
been established. The use of cefuroxime
axetil in pregnant women requires that
the likely benefit from the drug be
weighed against the possible risk to the
mother and fetus.

8. In present lots of pharmaceutical industry
commercially Manufacturing cefuroxime
axetil categories drug shown in table 1…

9. • Orion Pharma Ltd.
• 125mg x 20s pack: 300.00 MRP; 250mg x 20s pack: 500.00 MRP; 500mg x 12s pack:
540.00 MRP
• AXET
• Cefuroxime axetil 125mg/5ml suspension
• Suspension
• Orion Pharma Ltd.
• 70ml bot: 215.00 MRP
• AXET
• Cefuroxime (as sodium salt) 250mg & 750mg/vial
• Injection (IV/IM)
• Orion Pharma Ltd.
• 250mg vial x 1s pack: 60.00 MRP; 750mg vial x 1s pack: 125.00 MRP
• AXETIL
• Cefuroxime axetil 125mg, 250mg & 500mg/tablet
• Tablet (Film Coated)
• Alco Pharma Ltd.
• 125mg x 12s pack: 144.00 MRP; 250mg x 8s pack: 176.00 MRP; 500mg x 8s pack: 320.00
MRP

10. • AXETIL
• Cefuroxime axetil 125mg/5ml suspension
• Suspension
• Alco Pharma Ltd.
• 70ml bot: 190.00 MRP
• AXIM
• Cefuroxime axetil 125mg, 250mg & 500mg/tablet
• Tablet (Film Coated)
• Aristopharma Ltd.
• 125mg x 10s pack: 150.00 MRP; 250mg x 20s pack: 500.00 MRP; 500mg x 10s pack:
450.00 MRP
• AXIM
• Cefuroxime axetil 125mg/5ml suspension
• Suspension
• Aristopharma Ltd.
• 70ml bot: 198.00 MRP
• AXIM
• Cefuroxime (as sodium salt) 750mg/vial
• Injection (IV/IM)
• Aristopharma Ltd.
• 1 vial pack: 125.00 MRP
• CEBAC-A
• Cefuroxime axetil 125mg/tablet
• Tablet (Film Coated)
• Seema Pharmaceuticals Ltd.
• 125mg x 8s pack: 120.00 MRP

11. • CEFOTIL
• Cefuroxime axetil 125mg, 250mg & 500mg/tablet
• Tablet (Film Coated)
• Square Pharmaceuticals Ltd.
• 125mg x 20s pack: 300.00 MRP; 250mg x 20s pack: 500.00 MRP; 500mg x 6s pack: 270.00 MRP
• CEFOTIL
• Cefuroxime axetil 125mg, 250mg & 500mg/tablet
• Tablet (Film Coated)
• Square Pharmaceuticals Ltd.
• 125mg x 20s pack: 300.00 MRP; 250mg x 20s pack: 500.00 MRP; 500mg x 6s pack: 270.00 MRP
• CEFOTIL
• Cefuroxime axetil 125mg/5ml suspension
• Suspension
• Square Pharmaceuticals Ltd.
• 70ml bot: 198.00 MRP
• CEFOTIL 1.5 IV
• Cefuroxime (as sodium salt) 1.5gm/vial
• Injection (IV)
• Square Pharmaceuticals Ltd.
• 1.5gm vial x 1s pack: 200.00 MRP
• CEFOTIL 750
• Cefuroxime (as sodium salt) 750mg/vial
• Injection (IV/IM)
• Square Pharmaceuticals Ltd.
• 750mg vial x 1s pack: 125.00 MRP

12. Weakness
• side effects of cefuroxime (Ceftin):
Get emergency medical help if you have any of
these signs of an allergic reaction: hives; difficulty
breathing; swelling of your face, lips, tongue, or
throat.
Call your doctor at once if you have any of these
serious side effects:
• diarrhea that is watery or bloody;
• fever, chills, body aches, flu symptoms;
• chest pain, fast or pounding heartbeats;
• unusual bleeding;
• blood in your urine;
• seizure (convulsions);
• pale or yellowed skin, dark colored urine, fever,
confusion or weakness;
• jaundice yellowing of the skin.

13. • Adverse Reactions:
Cefuroxime Axetil Tablets in Clinical
Trials: Multiple-Dose Dosing Regimens: 7
to 10 Days Dosing Using multiple doses
of Cefuroxime Axetil tablets, 912
patients were treated with Cefuroxime
Axetil (125 to 500 mg twice daily). There
were no deaths or permanent
disabilities thought related to drug
toxicity.

14. • Abdominal pain
• Abdominal cramps
• Flatulence
• Indigestion
• Headache
• Vaginitis
• Rash
• Hives
• Itch
• Dysuria
• Chills
• Chest pain
• Shortness of breath
• Mouth ulcers
• Swollen tongue
• Sleepiness

15. • precautions when taking cefuroxime
axetil (Ceftin):
Before taking cefuroxime, tell your
doctor or pharmacist if you are allergic
to it; or to penicillins or other
cephalosporin antibiotics (e.g.,
cephalexin); or if you have any other
allergies. This product may contain
inactive ingredients, which can cause
allergic reactions or other problems. Talk
to your pharmacist for more details.

16. Opportunity
• Pseudomembranous colitis has been reported
to be associated with the use of cefuroxime
axetil and other broad-spectrum antibiotics.
Therefore, it is important to consider its
diagnosis in patients administered cefuroxime
axetil who develop diarrhea. Treatment with
broad-spectrum antibiotics, including
cefuroxime axetil, alters the normal flora of the
colon and may permit overgrowth of Clostridia.
Studies indicate that a toxin produced by C.
difficile is one primary cause of antibiotic-
associated colitis. Mild cases of colitis may
respond to drug discontinuance alone.

17. Moderate to severe cases should be
managed with fluid, electrolyte, and
protein supplementation as indicated.
When the colitis is severe or not relieved
by discontinuance of cefuroxime axetil
administration, consideration should be
given to the administration of oral
vancomycin or other suitable therapy.
Other possible causes of colitis should
also be considered.

18. Threat
• In present time cefruoxime axetil in
Bangladesh lots of pharmaceutical
produce this types of drug and doctors
should be prescribed this drug too much
for the treatment. cefroxime axetil is a
second generation drug for this condition
it should be prevented many microbial
agent.Many pharmaceutical industry
produce this categoris drug so that they
uses lots of API that’s vary the price of
this drug for example:

19. CEFOBAC 1.5 IV
Cefuroxime (as sodium salt) 1.5gm/vial
Injection (IV)
Popular Pharmaceuticals Ltd.
1 vial pack: 200.00 MRP
On the other hand
AXIM
Cefuroxime (as sodium salt) 750mg/vial
Injection (IV/IM)
Aristopharma Ltd.
1 vial pack: 125.00 MRP
In this list we make little difference between two companies
product.price make a fact to compare with two
pharmaceutical industries product.