Adrenogenital syndrome (androgen insensitivity syndrome or congenital adrenal hyperplasia)
Starts in embryo and fetus
Inability to synthesize corticosteroids so body releases massive amounts of ACTH
Results in hyperplasia of the adrenal cortex and causes release of intermediary hormones that have a testosterone-like effect, virilization in newborn girls and enlarged penis and premature puberty in males. Most have salt-losing problem.
Treat with oral corticosteroids to inhibit release of ACTH