PRP Art & science

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PRP art &science

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PRP Art & science

  1. 1. Platelet Rich Plasma Art & science Islam Kassem,BDS,MSc,FDS RCS Consultant oral & maxillofacial Surgeon ikassem@dr.com
  2. 2. Angle Face Left New technology of injection your own blood to get a Youthful Look . . ikassem@dr.com
  3. 3. Why Are Celebrities Injecting Their Faces With Blood? ikassem@dr.com
  4. 4. ikassem@dr.com
  5. 5. Platelet?  Anuclear piece of cytoplasm  Include hemostasis, α-granule,lysosomal granule, dense granules ikassem@dr.com
  6. 6.  At least 7 different growth factors that stimulate bone & soft tissue healing  PDGF aa,bb,ab  TGF b1,b2  VEGF  EGF ikassem@dr.com
  7. 7. Days of operation ikassem@dr.com
  8. 8. 7 days later  PLT exhausted after 7 days  Macrophage by low oxygen tension, acidity, lactate concentration  Secrete same growth factors  Activated until it is down regulated by the restoration of normal oxygen tension ikassem@dr.com
  9. 9. Day 3rd ikassem@dr.com
  10. 10. 17days  Graft is completely permeated by new capillaries  Initial osteoid formation  Osteoclast resorb osteoid and BMP released  New bone formation and maturation ikassem@dr.com
  11. 11. Days 14 ikassem@dr.com
  12. 12. The mechanism of growth factor effects on cells Inactive state ikassem@dr.com
  13. 13. Activation activation ikassem@dr.com
  14. 14. Clinical effects of PRP on bone regeneration Platelet RBC Normal blood PRP ikassem@dr.com
  15. 15. Trabecular areaNative mandible Autogenous BG ikassem@dr.com
  16. 16. Clinical effects of PRP on soft tissue healing  Split thickness skin graft donor site healing ikassem@dr.com
  17. 17. 6 days Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue ikassem@dr.com
  18. 18. 6 months Thrombin side : scarring hypo and hyper- pigmentation area PRP side ;less scarring Much less pigmentation change ikassem@dr.com
  19. 19. Patient discomfort  Patient discomfort decrease ikassem@dr.com
  20. 20. Epithelization ikassem@dr.com
  21. 21. 6days ↔ ↔ ikassem@dr.com
  22. 22. 1 months ikassem@dr.com
  23. 23. Contraindications  Pre-existing coagulation defect : thrombocytopenia, hypofibrinogenia…  Hypersensitivity to bovine thrombin ikassem@dr.com
  24. 24. Clinical steps ikassem@dr.com
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  30. 30. Clinical application ikassem@dr.com
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  38. 38. Ridge preservation ikassem@dr.com
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