Neuroscience i cm
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Neuroscience i cm

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Neuroscience i cm Neuroscience i cm Presentation Transcript

    • IntroPsych 1XX3 Live Lecture
    • Neuroscience I
    When good neurons go bad…
  • Introduction
  • 100 billion
  • Neurons are Communication Cells Dendrites Nucleus Axon Myelin Sheath Schwann Cell Node of Ranvier Axon Terminal Cell Body (Soma)
  • Thought and Behaviour
  • The Receptive Zone
    • IntroPsych 1XX3 Live Lecture
    • Neuroscience I
    Module 2: Receptor Trafficking
  • MOR Gene Disruption of MOR gene disrupts function of morphine Matthes et al., (1996); Sora et al., (1997); Loh et al., (1998); Monory et al., (2000)
  • The Life Cycle of a Receptor
  • Morphine Morphine Endorphin Mu-Opioid Peptide Receptor
  • MOP Receptors The fate of the MOP receptor depends on what binds to it. No Treatment Endorphin Heroin
  • Mice with designer genes RMOR s: R ecycling M u- O pioid R eceptor Knock-in Mouse Line RMOR MOR
  • Knock-in vs. Wild-type
  • KI mice show reduced withdrawal behaviours. +/+ -/-
    • IntroPsych 1XX3 Live Lecture
    • Neuroscience I
    Module 3: Receptor Expression
  • Structural changes in the “addicted” neurons Robinson and Kolb (1997)
  • Dopamine and Reward Cue Response Reward DOPAMINE (DA)
  • Chronic cocaine reduces DA receptor availability Healthy Brain Addicted Brain
  • Social Rank Morgan et al., (2002) Nat. Neurosci Social rank correlated with DA receptor function and subsequent vulnerability to addiction
    • IntroPsych 1XX3 Live Lecture
    • Neuroscience I
    Module 4: Myelin Sheath
  • The Action Potential
  • Multiple Sclerosis
    • A myelination disorder
    • Immune breakdown of myelin
    • Oligodendrocytes reproduce thinner, weaker myelin
    • Plaques and scars forms in the white matter
  • Prognosis Disease progression worsens throughout life
  • Life Expectancy Life expectancy 5-10 years lower than average There is no known cure
  • Causes and Therapies
    • Genetic and Environmental
    • Not explicitly hereditary, but influenced by genes
    • A number of environmental risk factors
    • Numerous Therapies
    • Drug therapies tend to target only specific symptoms
    • IntroPsych 1XX3 Live Lecture
    • Neuroscience I
    Module 5: Mirror Neurons
  • New Caledonian Crow http://www.sciencemag.org/feature/data/crow/weirmovie.mov
  • Motor Neurons
  • Prediction
  • Empathy
  • Child Development Awww, you know that tickles!
  • Theory of Mind
  • Monkey See, Monkey Do
  •