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hormones from specialized cells in glands or tissue are secrected and transported in the blood to a distant site of action(classic “endocrine” effect), or act directly upon nearby cells which is called “paracrine” activity.
Classification of endocrine disease 1. primary endocrine disorder 2. secondary to other disease 3. ectopic endocrine disorder 4. due to receptor dysfunction 5. heredity abnormal hormones 6. iatrogenic
Clinical picture history 、 symptom 、 sign Lab findings evidence of metabolic disturbance: target tissue or/and organs function evidence of inappropriate hormone ： hormones or their metabolite of endocrine function test immunology Diagnosis
Imageology X ray ， CT ， B ultrasound ， isotope Histology and cytology Cytogenetics Diagnosis
Typical features in endocrine disease dwarfism gigantism acromegaly
Typical features in endocrine disease Cushing syndrome hyperthyroidism Cretinism Addison disease