Your SlideShare is downloading. ×
  • Like
  • Save
Adverse Food Reactions
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×

Now you can save presentations on your phone or tablet

Available for both IPhone and Android

Text the download link to your phone

Standard text messaging rates apply

Adverse Food Reactions

  • 250 views
Published

 

  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads

Views

Total Views
250
On SlideShare
0
From Embeds
0
Number of Embeds
0

Actions

Shares
Downloads
0
Comments
0
Likes
0

Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
    No notes for slide

Transcript

  • 1. Adverse Food Reactions A Seminar by Robert Buist PhD
  • 2. Malabsorption in Coeliac Disease (CD)
    • Malabsorption of iron, folate, calcium and fat soluble vitamins results in iron deficiency, folate deficiency and reduced bone density
  • 3. INFANT PRESENTATIONS
    • Infants and young children present with diarrhoea, abdominal distension and FAILURE TO THRIVE
  • 4. Mechanism underlying osteoporosis in CD
    • Calcium malabsorption
    • Vitamin D malabsorption
    • Secondary hyperparathyroidism
    • Failure of peak bone density as child
    • Reduced gonadal function in men
    • Autoimmunity
  • 5. CD is associated with:
    • Delayed menarche
    • Premature menopause
    • Amenorrhoea
    • recurrent miscarriages
    • Infertility & low birthweight babies
    • Increased perinatal mortality
  • 6. Autoimmune Diseases & Gluten
    • Coeliac Disease
    • Diabetes Mellitus
    • Autoimmune Thyroid Disease / MS
    • Rheumatoid Arthritis / Psoriasis
    • Glomerulonephritis
    • Antibodies disappear on a gluten free diet
  • 7. Common Misdiagnoses
    • Anaemia
    • Allergies
    • Thyroid Disease
    • Lactose Intolerance
    • IBS, CFS
  • 8. Autoimmune Disorders ten times more common in CD
    • IDDM
    • Thyroid disease
    • Sjogrens Disease
    • Renal Disease
    • Addisons Disease
    • Cardiomyopathy
    • Neurological disorders
    • Autoimmune liver disease
  • 9. Serological Tests for CD
    • Antibodies against gliadin
    • (IgA-AGA, IgG-AGA)
    • Endomysial antibody (IgA-EMA)
    • Tissue transglutaminase antibody
    • (IgA-tTG)
    • Total IgA
  • 10. Cancer and CD
    • Malignant diseases are more
    • frequent in coeliacs
    • Small bowel CA
    • Oesophageal & oropharangeal CA
    • Non-Hogkins lymphoma
  • 11. Exorphins & Behaviour
    • Autistic children respond to
    • gluten-free,casein-free diet
    • Improved speech, social behaviour, sleeping habits
    • Food peptides affect ADHD
    • Depression & morphine-like
    • exorphins
  • 12.
    • Oats are not toxic to patients with Coeliac Disease or Dermatitis Herpetiformis
  • 13. Candida & Coeliac Disease
    • Genetic link (HLA-DQ2 and HLA-DQ8) in patients with coeliac disease
    • Alpha-gliadin has immunoreactve peptides
    • Hyphal wall protein (HWP 1) in C. albicans. Similar epitopes in gliadin
  • 14.  
  • 15. Transglutaminases elevated in CD
    • Yeasts adhere to gut via transglutaminases
    • Gliadin deamidated via transglutaminases
    • Yeast & gluten provide T-cell epitopes
    • (reactive peptides which trigger antibodies)
    • Autoreactive antibodies form against tissue transglutaminases and endomysium peptides
  • 16. Affect of Antibiotics
    • Increased candida overgrowth
    • Damage to gut
    • Increased exposure of transglutaminases
    • Increased binding of candida HWP 1
    • Tissue transaminases (autoantigen) recognised by autoreactive antibodies
  • 17. Breast Feeding Protects against CD
    • Introduce gluten while breast feeding
    • Small quantities of gluten only
    • Keep breast feeding after gluten exposure
    • Breast feeding at exposure increases oral tolerance
    • Breast feeding protects against Diabetes type 1, IBS and Leukaemia
  • 18. Adverse Reactions to Milk
    • Milk Allergy
    • Milk Intolerance
    • Uncommon,
    • Small amounts trigger
    • IgE mediated
    • Reactions sudden
    • Common
    • Normal amounts trigger
    • Not IgE mediated
    • Skin tests Negative
    • Reactions delayed (4-26 days)
  • 19. Milk Intolerances
    • Masking- Remove dust, mould, dogs etc
    • Glue ear- Are parents atopic?
    • IBS- Milk & wheat increase rectal PG’s
    • Asthma- Look for milk addiction
    • Eczema- >2 allergens (related to asthma)
  • 20. Periorbital swelling due to milk
  • 21. Katherine’s writing age at six
  • 22. Fat consumption & Heart Disease (IHD)
    • Total Fat (% total energy)
    • No IHD IHD
    • Framington 38.8 40.0
    • Puerto Rico (urban) 36.6 37.7
    • Puerto Rico (rural) 32.2 32.0
    • Honolulu 33.3 35.2
    • London 40.5 40.0
    • Zutphen 41.7 41.8
    • Ireland/Boston 38.5 39.4
    • Caerphilly 40.1 40.9
  • 23. Dietary Lactose
    • Glucose-Galactose (disaccharide)
    • 12g per 250ml milk
    • Reduced in yogurt/fermented milk
    • Absent in hard cheese
    • Intolerance when lactase deficient
  • 24. Lactose - A possible Coronary Risk Factor
    • Examination of 23,207 sets of coronary arteries and aortas revealed severity of atherosclerosis was related to:
    • Highest daily milk consumption
    • Those with highest lactase activity
  • 25. Milk consumption & Lactase Activity
    • Correlation of Milk Intake with Persistent High Lactase Activity (PHLA) in 14 countries
    • Category Milk ( cals/day ) *PHLA (%)
    • 1 399 87
    • 2 259 30
    • 3 100 55
    • 4 117 37 5 119 29
    • *A precondition for drinking lots of milk
  • 26. IHD in France and Finland
    • Men 55-64 yrs had the same cholesterol and sat. fat intake (1950-1980) but IHD mortality was highest in Finland. Why?
    • (Wine and ethanol intake was the same)
    • The Finns drank 3.4 times more milk
  • 27. Milk verses Cheese
    • During 1972-92 there was a dramatic decline in IHD in Finland as milk consumption declined .
    •  Cheese intake increased 3 times during this period
  • 28. Countries with low IHD
    • Japan,China, Greenland Eskimos (heavy smokers, low wine intake)
    • Masai of East Africa (drink fermented milk low in lactose)
    • South African Blacks, Afro-Carribeans, Prima Indians, Shri Lankans (low milk,low lactose)
    • North Indians, Pakistanis and British have elevated IHD, high milk intake and high lactase levels
  • 29. Why French have lower IHD mortality
    • Milk intake - 66% less than UK
    • Fat intake - 33% more than UK
    • Cheese intake 300% more than fresh milk
    • Lactase activity:
    • Northern France - 50% less than Europe
    • Southern France - 25% less than Europe
  • 30. Lactose increases LDL oxidation
    • Galactose (and Fructose) preferentially glycate proteins especially LDL.
    • This makes LDL more susceptible to oxidation and thus atherosclerosis
  • 31. Foods & IHD mortality
    • Correlation between foods
    • & IHD mortality rates in 43 countries
    • Dietary Item r
    • Total Milk 0.75
    • Energy 0.72
    • Meat 0.65
    • Fats & oil 0.62
    • Protein 0.62
    • Total sugar 0.57
  • 32.
    • Is high lactose consumption merely
    • a marker for  -casein intake?
  • 33.  
  • 34.
    • “ The rate of  -Casein A1 consumption (excluding cheese) is a more accurate predictor of heart disease…. Than that reported for traditional risk factors”
  • 35. Conventional Risk Factors for CVD queried
    • CHOLESTEROL
    • BLOOD PRESSURE
    • SATURATED FATS
    • OBESITY
    • Varied in relative contribution to illness
    A survey of 39 centres in 26 countries
  • 36.  
  • 37. Incidence of Diabetes by Milk Consumption in Finland
  • 38. Myocardial Infarcts in Ulcer Patients who took Milk
  • 39.  
  • 40.  
  • 41. Comparison of A1 Casein consumption & Heart Attack Mortality
  • 42.  
  • 43.  
  • 44.  
  • 45. CHEESE CASEIN IS DIFFERENT TO THAT FOUND IN MILK
    • Rennet and subsequent enzymatic action as cheese ages causes alterations to
    • the cheese protein structure causing cross-linking of casein molecules.
    • Casomorphin-7 is absent in most cheeses
  • 46. Adverse effects of Casein
    • Casein causes heart disease in animals
    • Casein accelerates hypercholesterolaemia
    • and atherosclerosis in animals
    • Apo E deficient atherosclerosis prone mice get more lesions
    • Longevity in animals decreased by casein
    • (compared with soy and whey)
    • Pigs fed casein have elevated homocysteine
  • 47. Casein in Foods
    • Bakery products Ammonium caseinate
    • Creamed cheese Calcium caseinate
    • Frozen desserts
    • Custard, ice cream Potassium caseinate
    • Fruit sherbets
    • Coffee whiteners Sodium caseinate
    • Cottage cheese
    • Yogurt
    • � Also in fortified cereals, infant formulas, nutrition bars,
    • bakery glazes, salad dressings, sauces, whipped toppings