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ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
ERA-NETs 2013  Interfacultary Centre of Biomaterials – Univ. Liège
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ERA-NETs 2013 Interfacultary Centre of Biomaterials – Univ. Liège

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ERA-NETs 2013

ERA-NETs 2013

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  • 1. Interfacultary Centre of Biomaterials – Univ. Liège www.ceib.ulg.ac.be 4 departements – staff ~ 30 p1. Polymer synthesis• biodegradable polyesters• functionalized poly(methyl)acrylate2. Polymer processing• Hydrogels• Film• Dispersed materials : micelles, nano-microparticles• drug immobilisation3. Analytical• Solubility, Mw determination• Stability, release kinetics study• Particle characterisation4. In vitro toxicity• Hemocompatibiliy 1• Animal cell tox
  • 2. Particle Drug Delivery Drug formulationGENERALORGANISATION OF In vitro testingTHE RESEARCHPolymer synthesis Cell therapy – Tissue engineering In vivo testing VALORISATION : Patents – Close collaboration with industries – Analytical services 2
  • 3. Biodegradable polyesters Macromolecular engineering with controlled polymerisation mechanism of cyclic monomers such as lactides, lactones. Novel architectures: block graft, random star-branched copolymers PolymerTECH : more than 300 different polymer samples available Material type : thermoplastics, hydrogels, amphiphilic gels Batch size : from g to 100 g ; in the near future : Kg scale facilities with reactive extrusion polymerisationSynthetic polyelectrolytes Living radical polymerisation of acrylic monomers Stimuli-responsive polymers. Functionalized polymers with reactive groups for synthesisof bioconjugates and fluorescent labelling of biomaterials. Strongly adhering polymers 3 Bulk polymerisation and purification in aqueous medium
  • 4. Tissue engineering 4
  • 5. Research project proposals 5
  • 6. Amphiphilic Biodegradable and biocompatible Hydrogels for Tissue engineering and Drug Delivery Increase the softness of the material by increasing it’s hydrophilicity L - H - L L - H - L hydrophobe hydrophile 250 15 min 24 h 1 semaine 200 Prise de masse [%] 150 100 50 H 0 0 10 20 30 40 50 60 70 Proportion molaire de PEO [%] 6
  • 7. Biocompatibility Preclinical trials Histological evaluation after 2 weeks of implantation (subcutaneous on rat) With comonomer No comonomerMembrane without comonomer is broken
  • 8. Degradable textiles and stem cells. Multifilament Monofilament Multifilament Monofilament Osteoblast cells Stem cellsCell appearance after a 24 hours incubation with 3D textile (Confocal microscopyafter fibers morphology analysis (LIVE/DEAD Kit´s labeling)
  • 9. Biocompatible biodegradable composite gel / textile for tissue engineering
  • 10. Biocompatible nanocarrier for drug delivery systems Protein drug (Human Insulin)  Poly (ethylene oxide) O -BiocompatibilityH3CO -Hydrophilicity O C O - Eliminable through kidney n m  Poly-e-(caprolactone) PEO PCL -Biodegradability, -Compatibility with a wide range of other polymer -Relatively low cost. -High crystallinity
  • 11. 11
  • 12. Fluorescent polymer labellingPurposes :1. Biodistribution / bioelimination studies2. Intracellular trafficking studiesMain objective : new biocompatible polymers as possiblereplacement for classical non degradable polyethyethyleneoxide Techniques : 1. FACS analysis 2. Confocal microscopy 12
  • 13. Prof. Christian GRANDFILS www.ceib.ulg.ac.be C.Grandfils@ulg.ac.be 13
  • 14. MATERIA NOVA … in short
  • 15. Materia-Nova : R&D centre Site INITIALIS Mons • since 2000Site NATISS • non-profit organizationGhislenghien • 90 employees • turnover 2011 : 8,5 Mio€ • pure project financing • 2011: member of EMRA
  • 16. Business model « Materia-Nova » SMPC SDM SCMN INFLUX CHIPS BIOTECH P. Dubois M. Olivier R.Lazzaroni P. Damman R. Snyders R. Wattiez Fondamental Research Applied Research INDUSTRY
  • 17. Fields of expertise NanotechnologiesPlasma technologies Electrochemistry Polymers Sol-gels (Nano-)composites Structured Biopolymers surfaces Biodegradation Modelisation Synthesis Biotechnology Devices
  • 18. Our mission Research programs in collaboration with industrial partners Strategic partnership with multinational companies ... but also : Tests et analyses Scientific advice and consultancies
  • 19. PartnersAGC Galactic NittoArcelorMittal Galvapower Group RoquetteArkema Goodyear SojitzBAT Husqvarna SolvayBeaulieu Inergy SRCBTN Kabelwerk Eupen Techspace AeroEssilor Knauf TotalESE Lhoist ToyotaEvian Matrio VallourecFaurecia Nexans WhirlpoolFuterro NMC …
  • 20. BCRC, CERTECH, CTP & MATERIA NOVAwww.emra.eu
  • 21. Contact Luc LANGER General Manager Avenue Nicolas Copernic, 1 B-7000 Mons, Belgium Tel: +32 65 554902 e-mail: Luc.Langer@materianova.be Web: www.materianova.be

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