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The 13th International Review of
                                                                                   Bipolar Disorders
                                                    18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain
                                                                                                   www.irbd.org


Day 1 - Monday 18 March 2013 - Draft Programme
Theme: Categories & Dimensions -
Temperament, Spectrum and Associated Issues
Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session


09.00    Registration Opens (open for duration of conference)

         Morning plenary sessions - Gran Salón Andalucía

09.15    Pre-conference Workshop: Introduction to Impulsivity
         (in association with International Society for Research on Impulsivity)
         Chair: Prof A Swann (US)
         Impulsivity: Its measurement and its relationship to clinical phenomena
         Prof A Swann (US)
         Brain mechanisms of impulsivity and relationships to risky behaviour
         Dr L Mason (UK)/Prof R Rogers (UK)
         Practical aspects: Relationships to outcome, nonpharmacological and pharmacological treatments
         Prof J Scott (UK)/Prof E Jimenez (ES)


11.15    Refreshments - Vestíbulo, Salón Malaga & Salón Marbella


11.45    IRBD 2013 Welcome and Introduction
         Conference Chairman: Prof E Vieta (ES)
         EBF Director: Mr R Pendleton (UK)

12.00    MS1: European Bipolar Forum: Affective temperament
         Chair: Prof J Angst (CH)
         Bipolarity in patients with borderline personality disorders: What is
         specific and non-specific?
         Prof G Perugi (IT)
         Borderline in Cyclothymia, the role of irritable temperament
         Dr E Hantouche (FR)
         Prediction of suicidality in the community: The role of temperament
         Prof E Karam (LB)


13.30    Lunch and Poster session (PO1) - Vestíbulo, Salón Malaga & Salón Marbella

14.30    PS1: Temperaments as mediators of suicide risk,           PS2: Evolutionary aspects of bipolar disorders
         hopelessness and psychopathology in bipolar               and affective temperaments (Salón Alanda)
         disorders (Gran Salón Andalucía)                          Dr X Gonda (HU)
         Prof M Pompili (IT)




 A Cortex Congress Conference                         PROGRAMME CO-CHAIRS
The 13th International Review of
                                                                                  Bipolar Disorders
                                                    18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain
                                                                                                   www.irbd.org


Day 1 - Monday 18 March 2013 (Cont’d)
Theme: Categories & Dimensions - Temperament, Spectrum and Associated Issues
Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session

15.00    MS2: Neurobiological markers in                         MS3: Youth temperament and affective disorders
         bipolar illness (Gran Salón Andalucía)                  (Salón Alanda)
         Chair: Prof J K Rybakowski (PL)                         Chair: Prof M L Figueira (PT)
         Biological markers of staging in bipolar illness        Youth suicide attempts
         Prof F Kapczinski (BR)                                  Prof M L Figueira (PT)
         GSK-3beta and beta-catenin in the postmortem            The prodromal phase of bipolar disorder
         brain of bipolar and schizophrenic subjects             Prof G Faedda (US)
         Prof G Pandey (US)                                      Advances in assessment: fast and frugal
         The HPA Axis and cognition in bipolar disorder          methods of detection without over diagnosis
         Prof A Young (UK)                                       Prof E Youngstrom (US)
         Clinical and biological markers of lithium response     Delayed sleep offset and other markers of circadian
         Prof J K Rybakowski (PL)                                rhythm disruption are common in young people with
                                                                 emerging mood disorders
                                                                 Prof I Hickie (AU)

17.00    Refreshments - Vestíbulo, Salón Malaga & Salón Marbella

17.30    MS4: Clinical staging: Understanding the evolu-        MS5: The impact of co-morbidities on Bipolar
         tion of bipolar disorders and defining treat-          Chair: Prof G Perugi (IT) (Salón Alanda)
         ments for at risk and early onset cases
         Chair: Prof J Scott (UK) (Gran Salón Andalucía)        Obesity & bipolar disorder
                                                                Prof A Tortorella (IT)
         Clinical staging models for bipolar disorders:
         Understanding different approaches to staging          Affective temperament and
         Prof J Scott (UK)                                      smoking
                                                                Prof Z Rihmer (HU)
         An evidence map of psychosocial interventions for
         ‘at risk’, first episode and early onset bipolar       The impact of comorbidities of bipolar disorder -
         disorders                                              Alcohol, temperament and bipolar disorder
         Dr M Vallarino (IT)                                    Prof A Erfurth (AT)
         What do offspring studies teach us about clinical      Comorbidity and functioning
         staging models for bipolar disorders?                  Dr L Gutierrez-Rojas (ES)
         Prof A Duffy (CA)
                                                                Bipolar spectrum and heroin
         Examining the evidence for pharmacological             addiction - tendency to abuse or self-medication?
         treatments in recent onset bipolar disorder?           Prof I Maremmani (IT)
         Prof F Bellivier (FR)

19.30    DB1: What comes first? High level of impulsiveness or mood instability?
         Chair: Prof K Fountoulakis (GR) (Gran Salón Andalucía)
         Argument for impulsiveness
         Prof A Swann (US)
         Argument for mood instability
         Prof Z Rihmer (HU)
         Discussion: Prof K Fountoulakis (GR)

20.30    CLOSE of Day 1 and Welcome Reception
21.30    EBF International Scientific Advisory Committee Dinner
         IRBD 2014 Programming meeting



  A Cortex Congress Conference                        PROGRAMME CO-CHAIRS
The 13th International Review of
                                                                                   Bipolar Disorders
                                                  18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain
                                                                                                 www.irbd.org


Day 2 - Tuesday 19 March 2013 - Draft Programme
Theme: Changing Clinical Concepts -
Re-definitions, New Treatments & Evolution

Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session


09.00    MS6: Cognition and Bipolar Disorders                      PS3: Trauma and bipolar disorder
         Chair: Prof A Erfurth (AT) (Gran Salón Andalucía)         Chair: Dr G Faedda (US)
                                                                   Dr B Amann (ES)
         The assessment and treatment of cognitive
         deficits in bipolar disorder
         Prof A Martinez-Aran (ES)                                 PS4: Antidepressant use in Bipolar disorder II
         The burden of cognitive dysfunction                       Chair: Dr G Faedda (US)
         Prof G Sachs (AT)                                         Dr J Undurraga (ES)


10.00    Refreshments - Vestíbulo, Salón Malaga & Salón Marbella

10.30    The Paradigm Shift in Bipolar I Disorder (Lundbeck sponsored symposium)
         Chair - Prof E Vieta (ES) (Gran Salón Andalucía)

         Introducing clinically relevant subtypes in DSM-V
         Prof J van Os (NL)
         Managing the core manic symptoms and the depressive features in manic bipolar I
         Prof H Grunze (UK)
         Customised treatment of bipolar I patients
         Prof A Young (UK)
         Assertive treatment of bipolar I (remission and beyond)
         Prof E Vieta (ES)
         General discussion

12.30    KN1: Bipolar and anxiety disorders: Comorbidity and validity of episode length
         Prof J Angst (CH) (Gran Salón Andalucía)

13.00    Lunch and Poster session (PO2) - Vestíbulo, Salón Malaga & Salón Marbella

         Afternoon plenary sessions - Gran Salón Andalucía

14.00    Patient and physician perspectives in bipolar disorder (AstraZeneca sponsored symposium)
         Chair - Prof E Vieta (ES)

         Treatment approaches in bipolar disorder
         Prof A Young (UK)
         Evidence and issues in the real world
         Prof E Vieta (ES)
         Maximising patient outcomes: Bringing together perspectives
         Prof H McAllister-Williams (UK)
         Panel discussion




 A Cortex Congress Conference                         PROGRAMME CO-CHAIRS
The 13th International Review of
                                                                                  Bipolar Disorders
                                                  18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain
                                                                                                 www.irbd.org


Day 2 - Tuesday 19 March 2013 - Draft Programme - Cont
Theme: Changing Clinical Concepts -
Re-definitions, New Treatments & Evolution
Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session

16.00    Refreshments - Vestíbulo, Salón Malaga & Salón Marbella

16.30    MS7: Recent advances in the short-term treatment of bipolar depression
         Chair: Prof J Calabrese (US)
         Morbidity and mortality associated with bipolar depression
         Prof T Ketter (US)
         Short-term studies in bipolar depression using adjunctive designs
         Prof J Calabrese (US)
         Linking neurotransmitter receptors to novel mechanisms of therapeutic action and side-effect profiles
         Dr J Goikolea (ES)


18.00    MS8: Understanding the long-term perspective and options to help achieve long-term remission
         Chair: Prof K Fountoulakis (GR)
         Bipolar depression and interepisodal symptomatology
         Prof A González-Pinto (ES)
         Psychosocial interventions and physical care
         Dr C Torrent (ES)
         Refractoriness in bipolar disorder: Definitions and evidence-based treatment
         Prof K Fountoulakis (GR)


19.30    CLOSE Day 2

20.30    Gala Dinner and Presentation of EBF Lifetime Achievement Award




 A Cortex Congress Conference                       PROGRAMME CO-CHAIRS
The 13th International Review of
                                                                                     Bipolar Disorders
                                                   18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain
                                                                                                  www.irbd.org


Day 3 - Wednesday 20 March 2013 - Draft Programme
Theme: Understanding Disease Progression -
Advanced Diagnostics & Care, Today & Tomorrow
Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session

         Morning plenary sessions - Gran Salón Andalucía

09.00    KN2: Functional imaging abnormality in bipolar disorder: What changes and what doesn’t change
         across phases
         Chair:
         Dr P McKenna (ES)

09.30    KN3: Pharmacogenetics and personalized pharmacology of bipolar disorder
         Chair: Prof J Del Tito (US)
         Prof J Kelsoe (US)

10.00    MS9: Marking a border between bipolar and unipolar disorders
         Chair: Dr A Murru (ES)
         Risks and advantages of the use of antidepressants in bipolar depression
         Prof L Tondo (IT)
         Unipolar and bipolar schizoaffective disorders: diagnostic residuals or clinical entities?
         Dr A Murru (ES)

11.00    Refreshments - Vestíbulo, Salón Malaga & Salón Marbella

11.30    PS5: When first line treatment will not suffice          OP: Oral Platform sessions
         Chair: Prof J Cookson (UK)                               Chair:
         (Gran Salón Andalucía)                                   (Salón Alanda)
         The use of residential treatment for children and        Affective temperaments in the Tunisian general
         adolescents with bipolar disorder and psychological      Population - Dr R Zaibi Jomli
         resistance to it                                         Mixed hypomania with psychotic features congruent
         Prof R Bush (US)                                         for the depressed phase - Prof S Dilsaver
                                                                  Let’s face it: facial emotion processing is impaired in
         The severe part of the bipolar II spectrum: Border-
                                                                  bipolar disorder - Miss T Van Rheenen
         line personality and more persistant
                                                                  Mental imagery: an emotional amplifier for bipolar dis-
         psychopathology
                                                                  order? - Dr R MK Ng
         Prof J Deltito (US)
                                                                  Proposals for new paths to bipolarity, mixity,
         Factors associated with adherence to medication in       fibromyalgia and migraine - Dr G Treviranus
         a French cohort (FACE-BD) of bipolar patients            Could glutamate spectroscopy differentiate bipolar
         Prof R Belzeaux (FR)                                     depression from unipolar? - Dr M Taylor
                                                                  Prestige and bipolarity: An evolutionary perspective -
                                                                  Dr J Le Bas



13.00    KN4: Depot antipsychotic medication in bipolar disorder
         Prof J Cookson (UK) (Gran Salón Andalucía)


13.30    Closing Address and Close of Conference




 A Cortex Congress Conference                        PROGRAMME CO-CHAIRS

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Programa International Review of Bipolar Disorders Sevilla 2013

  • 1. The 13th International Review of Bipolar Disorders 18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain www.irbd.org Day 1 - Monday 18 March 2013 - Draft Programme Theme: Categories & Dimensions - Temperament, Spectrum and Associated Issues Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session 09.00 Registration Opens (open for duration of conference) Morning plenary sessions - Gran Salón Andalucía 09.15 Pre-conference Workshop: Introduction to Impulsivity (in association with International Society for Research on Impulsivity) Chair: Prof A Swann (US) Impulsivity: Its measurement and its relationship to clinical phenomena Prof A Swann (US) Brain mechanisms of impulsivity and relationships to risky behaviour Dr L Mason (UK)/Prof R Rogers (UK) Practical aspects: Relationships to outcome, nonpharmacological and pharmacological treatments Prof J Scott (UK)/Prof E Jimenez (ES) 11.15 Refreshments - Vestíbulo, Salón Malaga & Salón Marbella 11.45 IRBD 2013 Welcome and Introduction Conference Chairman: Prof E Vieta (ES) EBF Director: Mr R Pendleton (UK) 12.00 MS1: European Bipolar Forum: Affective temperament Chair: Prof J Angst (CH) Bipolarity in patients with borderline personality disorders: What is specific and non-specific? Prof G Perugi (IT) Borderline in Cyclothymia, the role of irritable temperament Dr E Hantouche (FR) Prediction of suicidality in the community: The role of temperament Prof E Karam (LB) 13.30 Lunch and Poster session (PO1) - Vestíbulo, Salón Malaga & Salón Marbella 14.30 PS1: Temperaments as mediators of suicide risk, PS2: Evolutionary aspects of bipolar disorders hopelessness and psychopathology in bipolar and affective temperaments (Salón Alanda) disorders (Gran Salón Andalucía) Dr X Gonda (HU) Prof M Pompili (IT) A Cortex Congress Conference PROGRAMME CO-CHAIRS
  • 2. The 13th International Review of Bipolar Disorders 18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain www.irbd.org Day 1 - Monday 18 March 2013 (Cont’d) Theme: Categories & Dimensions - Temperament, Spectrum and Associated Issues Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session 15.00 MS2: Neurobiological markers in MS3: Youth temperament and affective disorders bipolar illness (Gran Salón Andalucía) (Salón Alanda) Chair: Prof J K Rybakowski (PL) Chair: Prof M L Figueira (PT) Biological markers of staging in bipolar illness Youth suicide attempts Prof F Kapczinski (BR) Prof M L Figueira (PT) GSK-3beta and beta-catenin in the postmortem The prodromal phase of bipolar disorder brain of bipolar and schizophrenic subjects Prof G Faedda (US) Prof G Pandey (US) Advances in assessment: fast and frugal The HPA Axis and cognition in bipolar disorder methods of detection without over diagnosis Prof A Young (UK) Prof E Youngstrom (US) Clinical and biological markers of lithium response Delayed sleep offset and other markers of circadian Prof J K Rybakowski (PL) rhythm disruption are common in young people with emerging mood disorders Prof I Hickie (AU) 17.00 Refreshments - Vestíbulo, Salón Malaga & Salón Marbella 17.30 MS4: Clinical staging: Understanding the evolu- MS5: The impact of co-morbidities on Bipolar tion of bipolar disorders and defining treat- Chair: Prof G Perugi (IT) (Salón Alanda) ments for at risk and early onset cases Chair: Prof J Scott (UK) (Gran Salón Andalucía) Obesity & bipolar disorder Prof A Tortorella (IT) Clinical staging models for bipolar disorders: Understanding different approaches to staging Affective temperament and Prof J Scott (UK) smoking Prof Z Rihmer (HU) An evidence map of psychosocial interventions for ‘at risk’, first episode and early onset bipolar The impact of comorbidities of bipolar disorder - disorders Alcohol, temperament and bipolar disorder Dr M Vallarino (IT) Prof A Erfurth (AT) What do offspring studies teach us about clinical Comorbidity and functioning staging models for bipolar disorders? Dr L Gutierrez-Rojas (ES) Prof A Duffy (CA) Bipolar spectrum and heroin Examining the evidence for pharmacological addiction - tendency to abuse or self-medication? treatments in recent onset bipolar disorder? Prof I Maremmani (IT) Prof F Bellivier (FR) 19.30 DB1: What comes first? High level of impulsiveness or mood instability? Chair: Prof K Fountoulakis (GR) (Gran Salón Andalucía) Argument for impulsiveness Prof A Swann (US) Argument for mood instability Prof Z Rihmer (HU) Discussion: Prof K Fountoulakis (GR) 20.30 CLOSE of Day 1 and Welcome Reception 21.30 EBF International Scientific Advisory Committee Dinner IRBD 2014 Programming meeting A Cortex Congress Conference PROGRAMME CO-CHAIRS
  • 3. The 13th International Review of Bipolar Disorders 18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain www.irbd.org Day 2 - Tuesday 19 March 2013 - Draft Programme Theme: Changing Clinical Concepts - Re-definitions, New Treatments & Evolution Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session 09.00 MS6: Cognition and Bipolar Disorders PS3: Trauma and bipolar disorder Chair: Prof A Erfurth (AT) (Gran Salón Andalucía) Chair: Dr G Faedda (US) Dr B Amann (ES) The assessment and treatment of cognitive deficits in bipolar disorder Prof A Martinez-Aran (ES) PS4: Antidepressant use in Bipolar disorder II The burden of cognitive dysfunction Chair: Dr G Faedda (US) Prof G Sachs (AT) Dr J Undurraga (ES) 10.00 Refreshments - Vestíbulo, Salón Malaga & Salón Marbella 10.30 The Paradigm Shift in Bipolar I Disorder (Lundbeck sponsored symposium) Chair - Prof E Vieta (ES) (Gran Salón Andalucía) Introducing clinically relevant subtypes in DSM-V Prof J van Os (NL) Managing the core manic symptoms and the depressive features in manic bipolar I Prof H Grunze (UK) Customised treatment of bipolar I patients Prof A Young (UK) Assertive treatment of bipolar I (remission and beyond) Prof E Vieta (ES) General discussion 12.30 KN1: Bipolar and anxiety disorders: Comorbidity and validity of episode length Prof J Angst (CH) (Gran Salón Andalucía) 13.00 Lunch and Poster session (PO2) - Vestíbulo, Salón Malaga & Salón Marbella Afternoon plenary sessions - Gran Salón Andalucía 14.00 Patient and physician perspectives in bipolar disorder (AstraZeneca sponsored symposium) Chair - Prof E Vieta (ES) Treatment approaches in bipolar disorder Prof A Young (UK) Evidence and issues in the real world Prof E Vieta (ES) Maximising patient outcomes: Bringing together perspectives Prof H McAllister-Williams (UK) Panel discussion A Cortex Congress Conference PROGRAMME CO-CHAIRS
  • 4. The 13th International Review of Bipolar Disorders 18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain www.irbd.org Day 2 - Tuesday 19 March 2013 - Draft Programme - Cont Theme: Changing Clinical Concepts - Re-definitions, New Treatments & Evolution Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session 16.00 Refreshments - Vestíbulo, Salón Malaga & Salón Marbella 16.30 MS7: Recent advances in the short-term treatment of bipolar depression Chair: Prof J Calabrese (US) Morbidity and mortality associated with bipolar depression Prof T Ketter (US) Short-term studies in bipolar depression using adjunctive designs Prof J Calabrese (US) Linking neurotransmitter receptors to novel mechanisms of therapeutic action and side-effect profiles Dr J Goikolea (ES) 18.00 MS8: Understanding the long-term perspective and options to help achieve long-term remission Chair: Prof K Fountoulakis (GR) Bipolar depression and interepisodal symptomatology Prof A González-Pinto (ES) Psychosocial interventions and physical care Dr C Torrent (ES) Refractoriness in bipolar disorder: Definitions and evidence-based treatment Prof K Fountoulakis (GR) 19.30 CLOSE Day 2 20.30 Gala Dinner and Presentation of EBF Lifetime Achievement Award A Cortex Congress Conference PROGRAMME CO-CHAIRS
  • 5. The 13th International Review of Bipolar Disorders 18 - 20 March 2013 NH Hotel Convention Centre, Seville, Spain www.irbd.org Day 3 - Wednesday 20 March 2013 - Draft Programme Theme: Understanding Disease Progression - Advanced Diagnostics & Care, Today & Tomorrow Key: MS = Multiple, KN = Keynote, DB = Debate, OP = Oral Platform, PO = Posters, PS = Parallel Session Morning plenary sessions - Gran Salón Andalucía 09.00 KN2: Functional imaging abnormality in bipolar disorder: What changes and what doesn’t change across phases Chair: Dr P McKenna (ES) 09.30 KN3: Pharmacogenetics and personalized pharmacology of bipolar disorder Chair: Prof J Del Tito (US) Prof J Kelsoe (US) 10.00 MS9: Marking a border between bipolar and unipolar disorders Chair: Dr A Murru (ES) Risks and advantages of the use of antidepressants in bipolar depression Prof L Tondo (IT) Unipolar and bipolar schizoaffective disorders: diagnostic residuals or clinical entities? Dr A Murru (ES) 11.00 Refreshments - Vestíbulo, Salón Malaga & Salón Marbella 11.30 PS5: When first line treatment will not suffice OP: Oral Platform sessions Chair: Prof J Cookson (UK) Chair: (Gran Salón Andalucía) (Salón Alanda) The use of residential treatment for children and Affective temperaments in the Tunisian general adolescents with bipolar disorder and psychological Population - Dr R Zaibi Jomli resistance to it Mixed hypomania with psychotic features congruent Prof R Bush (US) for the depressed phase - Prof S Dilsaver Let’s face it: facial emotion processing is impaired in The severe part of the bipolar II spectrum: Border- bipolar disorder - Miss T Van Rheenen line personality and more persistant Mental imagery: an emotional amplifier for bipolar dis- psychopathology order? - Dr R MK Ng Prof J Deltito (US) Proposals for new paths to bipolarity, mixity, Factors associated with adherence to medication in fibromyalgia and migraine - Dr G Treviranus a French cohort (FACE-BD) of bipolar patients Could glutamate spectroscopy differentiate bipolar Prof R Belzeaux (FR) depression from unipolar? - Dr M Taylor Prestige and bipolarity: An evolutionary perspective - Dr J Le Bas 13.00 KN4: Depot antipsychotic medication in bipolar disorder Prof J Cookson (UK) (Gran Salón Andalucía) 13.30 Closing Address and Close of Conference A Cortex Congress Conference PROGRAMME CO-CHAIRS