RESIDUAL MONOMER--IT’S CYTOTOXIC POTENTIAL
INDIAN DENTAL ACADEMY
Leader in continuing dental education
www.indiandentalaca...
INTRODUCTION

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RESIDUAL MONOMER


The conversion of monomers to polymers –
un reacted monomers -- residual monomers



Residual monomer...
ALLERGIC STOMATITIS

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ANGULAR CHEILITIS

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RESIDUAL MONOMER
SIGNS AND SYMPTOMS.




Erythema
Erosion of oral mucosa
Burning sensation on mucosa and tongue

www.in...
RESIDUAL MONOMER



Allergic reaction
few to several hours
Allergic contact stomatitis .
Delayed type of hypersensitivit...
RESIDUAL MONOMER


In 1956 „Fisher‟ identified methyl
methacrylate monomers as the cause of
allergic dermatitis of 4 dent...
RESIDUAL MONOMER
Biocompatibility
Heat cure more than self cure
Allergic response
Self cure more than heat cure

www.india...
RESIDUAL MONOMER
CONTACT DERMATITIS

Other side effects
1.Contact dermatitis
2.Respiratory distress
3.Cardiovascular effec...
RESIDUAL MONOMER


Parameters to monitor cytotoxic effects of
dental materials are inhibition of cell
growth, cytolysis, ...
RESIDUAL MONOMER


“Smith ”found that in self cured acrylic
resins different areas of denture appeared
to have different ...
RESIDUAL MONOMER


An acrylic resin which contains high levels
of residual monomer may exhibit low
mechanical strength.
(...
FACTORS THAT INFLUENCE
CYTOTOXICITY OF DENTURE BASE
ACRYLIC RESINS
 Polymer to monomer ratio
 Type of polymerization cyc...
POLYMER TO MONOMER RATIO




„Kedjarune‟ et al the more monomer added to
the mixture the greater the amount of residual
...
POLYMERIZATION CYCLE
Extended polymerization time—low levels
of residual monomer—less cytotoxicity
Harrison and Huggett te...
POLYMERIZATION METHOD
Cytotoxicity
Auto polymerizing > Heat cure >Microwave



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WATER STORAGE
Water storage for 24 hrs
 Longer storage--less cytotoxicity
 50c for 60 min—reduce monomer—less
cytotoxici...
CONCLUSION

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ACKNOWLEDGEMENTS








Dr. P. MAHESH. M.D.S.(PROFF& HOD)
Dr. P. SRINIVASA RAO.M.D.S.( ASS.PROFF)
Dr. SASI DEEPTHI...
THANK YOU

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Residual monomer --it’s cytotoxicity /certified fixed orthodontic courses by Indian dental academy

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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.

Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078

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Residual monomer --it’s cytotoxicity /certified fixed orthodontic courses by Indian dental academy

  1. 1. RESIDUAL MONOMER--IT’S CYTOTOXIC POTENTIAL INDIAN DENTAL ACADEMY Leader in continuing dental education www.indiandentalacademy.com www.indiandentalacademy.com
  2. 2. INTRODUCTION www.indiandentalacademy.com
  3. 3. RESIDUAL MONOMER  The conversion of monomers to polymers – un reacted monomers -- residual monomers  Residual monomer has the potential to cause Irritation Inflammation Allergic response & Stomatitis Angular cheilitis www.indiandentalacademy.com
  4. 4. ALLERGIC STOMATITIS www.indiandentalacademy.com
  5. 5. ANGULAR CHEILITIS www.indiandentalacademy.com
  6. 6. RESIDUAL MONOMER SIGNS AND SYMPTOMS.    Erythema Erosion of oral mucosa Burning sensation on mucosa and tongue www.indiandentalacademy.com
  7. 7. RESIDUAL MONOMER   Allergic reaction few to several hours Allergic contact stomatitis . Delayed type of hypersensitivity ---Hypersensitivity of mucosa and skin. www.indiandentalacademy.com
  8. 8. RESIDUAL MONOMER  In 1956 „Fisher‟ identified methyl methacrylate monomers as the cause of allergic dermatitis of 4 dentists and dental laboratory technicians. www.indiandentalacademy.com
  9. 9. RESIDUAL MONOMER Biocompatibility Heat cure more than self cure Allergic response Self cure more than heat cure www.indiandentalacademy.com
  10. 10. RESIDUAL MONOMER CONTACT DERMATITIS Other side effects 1.Contact dermatitis 2.Respiratory distress 3.Cardiovascular effects  www.indiandentalacademy.com
  11. 11. RESIDUAL MONOMER  Parameters to monitor cytotoxic effects of dental materials are inhibition of cell growth, cytolysis, changes in the metabolic activity ( Janaina Habib Jorge and E . Teresinha et al; Effect of post polymerization heat treatments on the cytotoxicity of two denture base acrylic resins Appl Oral Sci; 2006;14(3);203-7 ) www.indiandentalacademy.com
  12. 12. RESIDUAL MONOMER  “Smith ”found that in self cured acrylic resins different areas of denture appeared to have different percentage of residual monomer due to the difference in thickness of material. www.indiandentalacademy.com
  13. 13. RESIDUAL MONOMER  An acrylic resin which contains high levels of residual monomer may exhibit low mechanical strength. ( A. M. Fletcher and S. Purnaveja et al ;The level of residual monomer in self curing denture base materials Dent Res 1983 ;62 ( 2 );118-120 ) www.indiandentalacademy.com
  14. 14. FACTORS THAT INFLUENCE CYTOTOXICITY OF DENTURE BASE ACRYLIC RESINS  Polymer to monomer ratio  Type of polymerization cycle  Method of polymerization  Storage time and water immersion www.indiandentalacademy.com
  15. 15. POLYMER TO MONOMER RATIO   „Kedjarune‟ et al the more monomer added to the mixture the greater the amount of residual monomer and therefore more potential for cytotoxicity. Resins prepared with a high proportion of polymer to monomer ratio ( 5:3) resulted in significantly lower levels of residual monomer as compared to those prepared with a lower ratio(4:3) www.indiandentalacademy.com
  16. 16. POLYMERIZATION CYCLE Extended polymerization time—low levels of residual monomer—less cytotoxicity Harrison and Huggett tests 7hr at 700c 1hr at 1000c Maximum conversion of residual monomer www.indiandentalacademy.com 7hr at 600c 5min at 900c High residual monomer
  17. 17. POLYMERIZATION METHOD Cytotoxicity Auto polymerizing > Heat cure >Microwave  www.indiandentalacademy.com
  18. 18. WATER STORAGE Water storage for 24 hrs  Longer storage--less cytotoxicity  50c for 60 min—reduce monomer—less cytotoxicity ( Janaina Habib Jorge DDS, and E.Teresinha et al; cytotoxity of denture base acrylic resins: a literature review; J Prosthet dent 2003;90:190-3)  www.indiandentalacademy.com
  19. 19. CONCLUSION www.indiandentalacademy.com
  20. 20. ACKNOWLEDGEMENTS        Dr. P. MAHESH. M.D.S.(PROFF& HOD) Dr. P. SRINIVASA RAO.M.D.S.( ASS.PROFF) Dr. SASI DEEPTHI REDDY.M.D.S. Dr. KUMAR. M.D.S. Dr. DILEEP NAG.M.D.S. Dr. PAVAN.M.D.S. Dr. SUDHEER.M.D.S. www.indiandentalacademy.com
  21. 21. THANK YOU www.indiandentalacademy.com

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