Inflammation-1
Inflammation-1

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Shashi-12/02/13
Shashi-Mar 2000
Inflammation-2

INDIAN DENTAL ACADEMY
Leader in continuing dental education
www.indiandentalacademy.com

www.indiandentala...
Inflammation-3

"Opportunities are usually
disguised by hard work, so
most people don't recognize
them."
- Ann Landers
www...
Inflammation-4

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“Inflame” – to set fire.
Inflammation is “dynamic response of
vascularised tissue to injury.”
Is...
Inflammation-5

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Flush: capillary dilatation.
Flare: arteriolar dilatation.
Weal: exudation, edema.

www.indiandenta...
Inflammation-6

(Flare, Flush & Weal – Lewis)

Triple response

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Inflammation-7

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Inflammation-12

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Rubor : Redness – Hyperaemia.
Calor : Warm – Hyperaemia.
Dolor : Pain – Nerve, Chemical
med.
...
Inflammation-13

1. Vaso dilatation
2. Exudation - Edema
3. Emigration of cells
4. Chemotaxis

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Inflammation-14

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Inflammation-19



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Chemical substances synthesised or released
which mediate the changes in inflammation.
Histamin...
Inflammation-20



Acute:
Exudative Inflammation: excess fluid. TB lung.
 Suppuration/Purulent – Bacterial - neutrophils...
Inflammation-21

“Never let the competition define you.
Instead, you have to define yourself
based on a point of view you ...
Inflammation-22

Fibrosis/Scar
Resolution
Injury

Acute
Inflammation

Chronic
Inflammation

Abscess

Fungus
Virus
Cancers
...
Inflammation-23

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Inflammation-24

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Inflammation-33



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Flush, Flare &
Weal
Acute
inflammatory cells
- Neutrophils
Vascular damage
More exudation
Li...
Inflammation-34

"People who soar, are those
who refuse to sit back and
wish things would change."
Charles R. Swindoll
Aut...
Inflammation-35

Heat

Redness Swelling
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Pain Loss Of Func.
Shashi-Mar 2000
Inflammation-36
Inflammation-36

Dr. Venkatesh M. Shashidhar.
Associate Professor of Pathology
Fiji School of Medicine
www...
Inflammation-37

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Hemorrhage
Inflammation
Granulation tissue (soft callus)
Scar – Fibrosis (hard callus)
Remodel...
Inflammation-38

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Regeneration of injured tissue by parenchymal
cells of the same type
Replacement by connective ti...
Inflammation-39

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Labile cells - continuously dividing


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Stable cells - low level of replication


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Epidermis, mu...
Inflammation-40

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Most Important Mediators affecting Cell Growth
Present in serum or produced locally
Exert pleio...
Inflammation-41

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Occurs when repair by parenchymal
regeneration alone cannot be accomplished
Involves production o...
Inflammation-42

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Angiogenesis - New vessels budding from old
Fibrosis, consisting of emigration and
proliferation ...
Inflammation-43

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Induction of acute inflammatory response by
an initial injury
Parenchymal cell regeneration
Migra...
Inflammation-44

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Synthesis of ECM proteins
Remodeling of parenchymal elements to
restore tissue function
Remodelin...
Inflammation-45

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Shashi-Mar 2000
Inflammation-46

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Inflammation-47





After sutures are removed at one week, wound
strength is only 10% of unwounded skin
(Walker’ Law)
B...
Inflammation-48

www.indiandentalacademy.com

Shashi-Mar 2000
Inflammation-49

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Inflammation-50

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Inflammation-51

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Systemic
Age
Nutrition
Vitamin def.
Immune status
Other diseases

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Local
Infection...
Inflammation-52

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Healing – Proliferation & Differentiation.
Labile, Stabe & Permanent cells
Stages of Healing...
"Each time you are honest and conduct
yourself with honesty, a success force will
drive you toward greater success. Each
t...
Inflammation-54

www.indiandentalacademy.com
Leader in continuing dental education

www.indiandentalacademy.com

Shashi-Ma...
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INFLAMMATION /certified fixed orthodontic courses by Indian dental academy

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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.

Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078

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INFLAMMATION /certified fixed orthodontic courses by Indian dental academy

  1. 1. Inflammation-1 Inflammation-1 www.indiandentalacademy.com Shashi-12/02/13 Shashi-Mar 2000
  2. 2. Inflammation-2 INDIAN DENTAL ACADEMY Leader in continuing dental education www.indiandentalacademy.com www.indiandentalacademy.com Shashi-Mar 2000
  3. 3. Inflammation-3 "Opportunities are usually disguised by hard work, so most people don't recognize them." - Ann Landers www.indiandentalacademy.com Shashi-Mar 2000
  4. 4. Inflammation-4     “Inflame” – to set fire. Inflammation is “dynamic response of vascularised tissue to injury.” Is a protective response. Serves to bring defense & healing mechanisms to the site of injury. www.indiandentalacademy.com Shashi-Mar 2000
  5. 5. Inflammation-5    Flush: capillary dilatation. Flare: arteriolar dilatation. Weal: exudation, edema. www.indiandentalacademy.com Shashi-Mar 2000
  6. 6. Inflammation-6 (Flare, Flush & Weal – Lewis) Triple response www.indiandentalacademy.com Shashi-Mar 2000
  7. 7. Inflammation-7 www.indiandentalacademy.com Shashi-Mar 2000
  8. 8. Inflammation-8 www.indiandentalacademy.com Shashi-Mar 2000
  9. 9. Inflammation-9 www.indiandentalacademy.com Shashi-Mar 2000
  10. 10. Inflammation-10 www.indiandentalacademy.com Shashi-Mar 2000
  11. 11. Inflammation-11 www.indiandentalacademy.com Shashi-Mar 2000
  12. 12. Inflammation-12      Rubor : Redness – Hyperaemia. Calor : Warm – Hyperaemia. Dolor : Pain – Nerve, Chemical med. Tumor: Swelling – Exudation Loss of Function: www.indiandentalacademy.com Shashi-Mar 2000
  13. 13. Inflammation-13 1. Vaso dilatation 2. Exudation - Edema 3. Emigration of cells 4. Chemotaxis www.indiandentalacademy.com Shashi-Mar 2000
  14. 14. Inflammation-14 www.indiandentalacademy.com Shashi-Mar 2000
  15. 15. Inflammation-15 www.indiandentalacademy.com Shashi-Mar 2000
  16. 16. Inflammation-16 www.indiandentalacademy.com Shashi-Mar 2000
  17. 17. Inflammation-17 www.indiandentalacademy.com Shashi-Mar 2000
  18. 18. Inflammation-18 www.indiandentalacademy.com Shashi-Mar 2000
  19. 19. Inflammation-19     Chemical substances synthesised or released which mediate the changes in inflammation. Histamine by mast cells - vasodilatation. Prostaglandins – Cause pain & fever. Bradykinin - Causes pain. www.indiandentalacademy.com Shashi-Mar 2000
  20. 20. Inflammation-20  Acute: Exudative Inflammation: excess fluid. TB lung.  Suppuration/Purulent – Bacterial - neutrophils  Fibrinous – pneumonia – fibrin  Serous – excess clear fluid – Heart, lung  Haemorrhagic – b.v.damage - anthrax.   Chronic inflammation: with healing.  Grannulomatous – clusters of epitheloid* cells eg. TB, Fungus, Foreign body. www.indiandentalacademy.com Shashi-Mar 2000
  21. 21. Inflammation-21 “Never let the competition define you. Instead, you have to define yourself based on a point of view you care deeply about.” – Tom Chappel www.indiandentalacademy.com Shashi-Mar 2000
  22. 22. Inflammation-22 Fibrosis/Scar Resolution Injury Acute Inflammation Chronic Inflammation Abscess Fungus Virus Cancers T.B. etc. Ulcer Fistula Sinus www.indiandentalacademy.com Shashi-Mar 2000
  23. 23. Inflammation-23 www.indiandentalacademy.com Shashi-Mar 2000
  24. 24. Inflammation-24 www.indiandentalacademy.com Shashi-Mar 2000
  25. 25. Inflammation-25 www.indiandentalacademy.com Shashi-Mar 2000
  26. 26. Inflammation-26 www.indiandentalacademy.com Shashi-Mar 2000
  27. 27. Inflammation-27 www.indiandentalacademy.com Shashi-Mar 2000
  28. 28. Inflammation-28 www.indiandentalacademy.com Shashi-Mar 2000
  29. 29. Inflammation-29 www.indiandentalacademy.com Shashi-Mar 2000
  30. 30. Inflammation-30 www.indiandentalacademy.com Shashi-Mar 2000
  31. 31. Inflammation-31 www.indiandentalacademy.com Shashi-Mar 2000
  32. 32. Inflammation-32 www.indiandentalacademy.com Shashi-Mar 2000
  33. 33. Inflammation-33      Flush, Flare & Weal Acute inflammatory cells - Neutrophils Vascular damage More exudation Little or no fibrosis     Little signs Fibrosis, Chronic inflammatory cells – Lymphocytes Neovascularisation No/less exudation Shashi-Mar 2000 www.indiandentalacademy.com
  34. 34. Inflammation-34 "People who soar, are those who refuse to sit back and wish things would change." Charles R. Swindoll Author and Pastor www.indiandentalacademy.com Shashi-Mar 2000
  35. 35. Inflammation-35 Heat Redness Swelling www.indiandentalacademy.com Pain Loss Of Func. Shashi-Mar 2000
  36. 36. Inflammation-36 Inflammation-36 Dr. Venkatesh M. Shashidhar. Associate Professor of Pathology Fiji School of Medicine www.indiandentalacademy.com Shashi-12/02/13 Shashi-Mar 2000
  37. 37. Inflammation-37      Hemorrhage Inflammation Granulation tissue (soft callus) Scar – Fibrosis (hard callus) Remodeling & Wound strength www.indiandentalacademy.com Shashi-Mar 2000
  38. 38. Inflammation-38    Regeneration of injured tissue by parenchymal cells of the same type Replacement by connective tissue In other words Regeneration  Scar  www.indiandentalacademy.com Shashi-Mar 2000
  39. 39. Inflammation-39  Labile cells - continuously dividing   Stable cells - low level of replication   Epidermis, mucosal epithelium, GI tract epithelium etc Hepatocytes, renal tubular epithelium, pancreatic acini Permanent cells - never divide  Nerve cells, cardiac myocytes, skeletal mm www.indiandentalacademy.com Shashi-Mar 2000
  40. 40. Inflammation-40     Most Important Mediators affecting Cell Growth Present in serum or produced locally Exert pleiotropic effects; proliferation, cell migration, differentiation, tissue remodeling Regulate growth of cells by controlling expression of genes that regulate cell proliferation www.indiandentalacademy.com Shashi-Mar 2000
  41. 41. Inflammation-41    Occurs when repair by parenchymal regeneration alone cannot be accomplished Involves production of Granulation Tissue replacement of parenchymal cells with proliferating fibroblasts and vascular endothelial cells www.indiandentalacademy.com Shashi-Mar 2000
  42. 42. Inflammation-42    Angiogenesis - New vessels budding from old Fibrosis, consisting of emigration and proliferation of fibroblasts and deposition of ECM Scar remodeling, tightly regulated by proteases and protease inhibitors www.indiandentalacademy.com Shashi-Mar 2000
  43. 43. Inflammation-43    Induction of acute inflammatory response by an initial injury Parenchymal cell regeneration Migration and proliferation of parenchymal and connective tissue cells www.indiandentalacademy.com Shashi-Mar 2000
  44. 44. Inflammation-44    Synthesis of ECM proteins Remodeling of parenchymal elements to restore tissue function Remodeling of connective tissue to achieve wound strength www.indiandentalacademy.com Shashi-Mar 2000
  45. 45. Inflammation-45 www.indiandentalacademy.com Shashi-Mar 2000
  46. 46. Inflammation-46 www.indiandentalacademy.com Shashi-Mar 2000
  47. 47. Inflammation-47   After sutures are removed at one week, wound strength is only 10% of unwounded skin (Walker’ Law) By 3-4 months, wound strength is about 80% of unwounded skin (Walker’s Law) www.indiandentalacademy.com Shashi-Mar 2000
  48. 48. Inflammation-48 www.indiandentalacademy.com Shashi-Mar 2000
  49. 49. Inflammation-49 www.indiandentalacademy.com Shashi-Mar 2000
  50. 50. Inflammation-50 www.indiandentalacademy.com Shashi-Mar 2000
  51. 51. Inflammation-51      Systemic Age Nutrition Vitamin def. Immune status Other diseases       Local Infection Size or extent. apposition Blood supply Mobility Foreign body www.indiandentalacademy.com Shashi-Mar 2000
  52. 52. Inflammation-52       Healing – Proliferation & Differentiation. Labile, Stabe & Permanent cells Stages of Healing: 1-2-3-4…. Healing by First or Second intention. Skin wound healing - bone healing. Factors affecting healing – Local / Systemic www.indiandentalacademy.com Shashi-Mar 2000
  53. 53. "Each time you are honest and conduct yourself with honesty, a success force will drive you toward greater success. Each time you lie, even with a little white lie, there are strong forces pushing you toward failure." Joseph Sugarman Author and Marketing Specialist www.indiandentalacademy.com
  54. 54. Inflammation-54 www.indiandentalacademy.com Leader in continuing dental education www.indiandentalacademy.com Shashi-Mar 2000

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