ANALGESICS
INDIAN DENTAL ACADEMY
Leader in continuing dental education
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Definition: IASP
 Latin word “POENA” meaning “PUNISHMENT”


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

Nociception



Transduction



Transmission



Perception



Modulation

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www.indiandentalacademy.com
Definition:
 Greek word ANA-without , ALGESIA-pain


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

Opioid or Centrally acting or Narcotic



Nonopioid or Peripheral acting or non- narcotic

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

Produce inhibition of neuronal activity



Inhibit release of neurotransmitters by closing voltage gated calcium
chann...
Mu
 Kappa
 Delta
 sigma


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Inhibit synthesis of prostaglandins
 Inhibition of free radical formation
 Inhibition of cytokine synthesis or cellular ...
OPIOIDS
 Respiratory depression
 Nausea and vomiting
 Hypotension
 Constipation
 Urinary retention
 Physical dependa...
NSAIDS
peptic ulcers, GI bleeding
Na & water retention, renal failure
Bleeding, agranulocytosis
Asthma, skin rashes, pruri...


Persistent pain requires prophylactic therapy



Use oral medication whenever possible



Doses should be determined ...


Efficacy and ceiling effect



Speed of onset and duration of action



Specific side effects and metabolism



Dysp...


Clinician should know minimal number of drugs



Analgesic and antipyretic uses



Anti-inflammatory use



Consider...


Severity of pain



Medical history



Known allergy

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OPIOIDS
 NSAIDS


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www.indiandentalacademy.com
Anti depressants
 Anti convulsants
 Alpha 2 adrenergic agonists
 Anti epileptics


www.indiandentalacademy.com
www.indiandentalacademy.com
Essentials of medical pharmacology 5th edition- KD Tripathi
 Post graduate medical journal(dec 1984)-Robert G Twycross
 ...
Thank you
www.indiandentalacademy.com
Leader in continuing dental education

www.indiandentalacademy.com
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Analgesics general dentistry /certified fixed orthodontic courses by Indian dental academy

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Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.

Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients

State of the art comprehensive training-Faculty of world wide repute &Very affordable.

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Analgesics general dentistry /certified fixed orthodontic courses by Indian dental academy

  1. 1. ANALGESICS INDIAN DENTAL ACADEMY Leader in continuing dental education www.indiandentalacademy.com www.indiandentalacademy.com
  2. 2. www.indiandentalacademy.com
  3. 3. www.indiandentalacademy.com
  4. 4. Definition: IASP  Latin word “POENA” meaning “PUNISHMENT”  www.indiandentalacademy.com
  5. 5.  Nociception  Transduction  Transmission  Perception  Modulation www.indiandentalacademy.com
  6. 6. www.indiandentalacademy.com
  7. 7. Definition:  Greek word ANA-without , ALGESIA-pain  www.indiandentalacademy.com
  8. 8.  Opioid or Centrally acting or Narcotic  Nonopioid or Peripheral acting or non- narcotic www.indiandentalacademy.com
  9. 9.  Produce inhibition of neuronal activity  Inhibit release of neurotransmitters by closing voltage gated calcium channels  Activate descending inhibitory systems  Inhibit post synaptic neurons by increasing potassium channel conductance www.indiandentalacademy.com
  10. 10. Mu  Kappa  Delta  sigma  www.indiandentalacademy.com
  11. 11. Inhibit synthesis of prostaglandins  Inhibition of free radical formation  Inhibition of cytokine synthesis or cellular signaling mechanisms mediating inflammation  Inhibition of prostaglandins in hypothalamus, spinal cord and inhibiting nitric oxide synthesis in macrophages-PARACETAMOL  www.indiandentalacademy.com
  12. 12. OPIOIDS  Respiratory depression  Nausea and vomiting  Hypotension  Constipation  Urinary retention  Physical dependance  tolerance  www.indiandentalacademy.com
  13. 13. NSAIDS peptic ulcers, GI bleeding Na & water retention, renal failure Bleeding, agranulocytosis Asthma, skin rashes, pruritis, angioedema ASPIRIN: salicylism at doses of 3-6gms/day Reyes syndrome Acute salicylate poisoning  www.indiandentalacademy.com
  14. 14.  Persistent pain requires prophylactic therapy  Use oral medication whenever possible  Doses should be determined on individual basis  Keep it simple  Insomnia must be treated vigorously  Admission is sometimes necessary to achieve pain control  Balance between degree of relief and unwanted side effects www.indiandentalacademy.com
  15. 15.  Efficacy and ceiling effect  Speed of onset and duration of action  Specific side effects and metabolism  Dysphoria  Toxic metabolites  Partial agonists and mixed agonists and antagonists www.indiandentalacademy.com
  16. 16.  Clinician should know minimal number of drugs  Analgesic and antipyretic uses  Anti-inflammatory use  Consider substitution if there is no response with one drug  Avoid using multiple nsaids  Topical or systemic administration  Nsaids in pregnancy www.indiandentalacademy.com
  17. 17.  Severity of pain  Medical history  Known allergy www.indiandentalacademy.com
  18. 18. OPIOIDS  NSAIDS  www.indiandentalacademy.com
  19. 19. www.indiandentalacademy.com
  20. 20. Anti depressants  Anti convulsants  Alpha 2 adrenergic agonists  Anti epileptics  www.indiandentalacademy.com
  21. 21. www.indiandentalacademy.com
  22. 22. Essentials of medical pharmacology 5th edition- KD Tripathi  Post graduate medical journal(dec 1984)-Robert G Twycross  Clinical implications of cox-2 inhibitors for acute dental pain management-JADA 2005(136)  The efficacy of combination analgesic therapy for relieving dental painJADA 2002(133)  Drugs for pain management in dentistry- Australian dental journal 2005 (50)  Newer NSAIDS-A review of their therapeutic potential and adverse drug reactions Journal, Indian academy of clinical medicine 2002(3)  www.indiandentalacademy.com
  23. 23. Thank you www.indiandentalacademy.com Leader in continuing dental education www.indiandentalacademy.com

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