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Protective effects of commelina benghalensis linn (root) extract on ethanol induced acute hepatotoxicity in rats ijsit 2.3.1

by Faculty at University on Jul 15, 2013

  • 234 views

The present study was undertaken to investigate the protective effect and possible mechanism of ...

The present study was undertaken to investigate the protective effect and possible mechanism of
alcoholic (AlE) and aqueous extract (AqE) from Commelina benghalensis root (CB) on EtOH-induced hepatic
injury in Wistar rat. Hepatotoxic parameters studied in vivo include serum transaminases (AST, and ALT),
ALP, bilirubin, protein, lipid profile (Cholesterol, triglyceride, VLDL and HDL) and level of antioxidants
together with histopathological examination. Liv 52® was used as a reference hepatoprotective agent
(5ml/kg-1b.w.). AlE and AqE (200 mg/kg-1b.w.) on oral administration decreased the level of AST, ALP, ALT,
bilirubin, cholesterol, triglyceride, VLDL, MDA and increased the level of protein, HDL and antioxidants (SOD,
GSH and CAT) in rats being treated with ethanol (EtOH). Pentobarbitone -induced sleeping time study was
carried out to verify the effect on microsomal enzymes Histopathological observations confirmed the
beneficial roles of MF against EtOH-induced liver injury in rats. Possible mechanism may involve their
antioxidant activity

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Protective effects of commelina benghalensis linn (root) extract on ethanol induced acute hepatotoxicity in rats ijsit 2.3.1 Protective effects of commelina benghalensis linn (root) extract on ethanol induced acute hepatotoxicity in rats ijsit 2.3.1 Document Transcript