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Status of relationship Development plan Partners Ministry of Industry and Trade Ministry of Economic Development Cooperation with Government of the Russian Federation April 2001: Agreement, on cooperation and coordination of joint activities in the innovative development of health signed .
May 2011:Coordinating Council for Biomedical Technologies established
Joint expertise and support of innovative projects
Working Group “Drug manufacturing and R&D “ with the Commission on Modernization and Technical development under the management of RF President .
Active participation and implementation of proposals of the Skolkovo Fund in Interdepartmental governmental Working Groups and committees on Biomedicine and biopharmaceuticals
Status of relationship Development plan Partners JSC “RUSNANO” EMBL (European Molecular Biology Laboratories ) - European leading interstate Centre for Molecular Biology Cooperation with institutional partners
March 2011: Agreements with Infrastructural RVC Venture Funds: Biofund RVC, Maxwell Biotech, BioProcess Capital Ventures - were signed.
May 2011: Joint expertise and structuring of 7 projects
Structuring of possible RVC participation .CSF "Preclinical studies with GLP standards”
Co-financing of at least 3 projects in conjunction with RVC Funds.
Starting with 2 joint educational practice-oriented modules .
March 2011г: Agreement of creation Coordinating Council for Biomedical Technologies was signed. April - May 2011: Joint expertise and structuring of 3 projects with "ROSNANO April-May 2011: Jjoint (with IGB RAS), educational module, "System analysis of genomic data”, in collaboration with Cold Spring Harbor Laboratory (USA)
April 2011: Agreement with the EMBL was signed.
April - May 2011: Consultations on the establishment of of EMBL R&D Institute in Skolkovo
April - May 2011: Participation of the EMBL in the CSF "Structural biology ” (in collaboration with the MIPT and ONEXIM Group)
Participation of EMBL in CSF "Structural biology in collaboration with the MIPT and ONEXIM Group)
Status of relationship Participants Development plan Partners Cooperation with regional biomedicine and biopharmaceutical clusters Feb 2011 Agreement of joining the BMT Cluster to the Supervisory Board of the BFC “Severny“ signed Feb-May 2011Joint educational program Apr-May 2011Some of the BFC “Severny” participants got the resident status
Joint support for the best innovative projects of BFC “Severny”
Using best practices (a business incubator, technopark, CSF, educational programs) i
Biopharmcluster “Severny” (MIPT) Ural Pharmcluster Feb 2011 Agreement of the Supervisory Board of the Ural Pharmcluster signed Feb-May 2011Examination of joint projects Apr 2011Some of the Ural Pharmcluster participants get the resident status of the Fund
Creating the «educationalenvironment» within the BMT Сluster 5
Status of relationship Development Plan Partners RUSNANO, Institute of Gene, Cold Spring Harbor Laboratory ASTRA ZENECA Co (UK) Educational Programs of BMT Cluster
Conducting 2nd session of the "Talent Pool“ program
Choosing of the foreign universities-partners, the agreements signing for training of young scientists, graduates of "UMNIK-Skolkovets”, student exchange programs, development of internship programs and trainings
March 2011The final of the first session of the qualifying competition program. The program, “The Talent pool of young scientists of BMT Cluster “ (UMNIK-Skolkovets), in which 34 young professionals were selected, Bortnik’s Fund
Integration of the “Statistical analysis of genomic data” into CSF for “Medicine bioinformatics” of BMT Cluster
Development. testing and, running of a new educational programs
March-May 2011 Practice-oriented educational module of “Statistical analysis of genomic data” is under testing May 2011 first students (BMT Cluster residents, RUSSNANO project companies, MIPT students, “Umnik-Skolkovets” graduates) March 2011 BMT Cluster joining Supervisory Board of «Knowledge Vanguard» Virtual University, established by Astra Zeneca with the participation of RUSNANO, RVC, the Ministry of Health and Social Development of Russia April 2011: Applications expertise within the competition of research projects in cardiology and oncology
Completion of the contest and awarding the winners.
Involvement of the winners in the educational and grant programs of BMT Cluster.
Development of ASTRA ZENECA’s training programs in within the framework of the Coordinating Council of BMT Cluster and the Ministry of Health and Social Development of Russia
Projects of Biomed Cluster (20/6) Financing were approved by Investment Committee for six projects 7
Projects of Biomed Cluster Fifteen projects received Participant Certificate 8
Projects of Biomed Cluster Fifteen projects received Participant Certificate 9
10 Collaboration with key partners Institutional partners Major biomed and pharmaceutical companies Agreement will be signed Jun, 17 ($15M) General MoU Agreement will be signed soon (15FTE in R&D M&S Centre) General MoU Leading Universities Regional Pharma Clusters Ural PharmCluster (Yekaterinburg) Pharm Cluster Severny (North of Moscow)
Transgenomicand postgenomic technologies Foresight. Biomedicine and Bio-pharmaceutics Proteomics , and other omics Regenerative medicine « Preclinical and clinical studies. P4 Medicine. Cancer ) Infection diseases » « Preclinical. GLP Structural Biology AB and other novel therapies » Registration and launch Lead optimization Preclinical Clinical - Early development Complex modeling and simulation. Biomedical Informatics Foresight Bioinformatics Artificial ecosystems Directed evolution Scaling up Foresight й Industrial biotechnologies Synthetic biology CSFs and the BMT foresights. Equipment and competencies 12
Basic Principles of BMT CSF functioning CSF research areas should be in the BMT foresights. CSF should provide services, research and educational programmes 1) 2) CSF should provide and maintain excellence in access to modern biomedical equipment, research infrastructure, highly qualified staff, and services on the world level Infrastructure facilities, the equipment and maintenance services of CSFs are to be 100% owned by the Skolkovo Foundation or/and its wholly owned subsidiary. 3) 4) Residents of the Skolkovo should have a first right to use CSFs services and competencies. There should be astrong demand for competences of CSF Capital expenses for major consumables and equipment are covered by the Fund. Operational budget to be provided by residents companies and external customers. 5) CSF establishment in the field of interest is supported by independent scientific experts 6) 13
Existing equipment Existing methodologies and techniques Staff Skills and experience Commercialisation experience Existing scientific collaborations Services Educational and retraining programmes Innovation projects Research and Development New Equipment Project companies. CSF customers New qualified staff Key partners Effective management BMT CSF Using existing competencies and adding novel ones. 14
0 BMT CSF development pipeline 2014 2012 - 2013 2011 Residents Projects Link-labs are based on project companies activities Infrastructural Link-Labs (Project based). Infrastructures Centers for Shared Facilities (CSF) or CoE Part of the R & D centers establishes on the basis of Centers for Shared Facilities R & D centers with key partners Functioning of the BMT infrastructural Ecosystem University Educational programs based on the project companies community and infrastructure partners Develop and implement the modules of special lectures and seminars (including "remote web – courses”) Creation of Departments of Skolkovo University Co-investors and strategic projects partners Long-term relationships with strategic investors Investors Venture Capital Funds Creating a network of business incubators Institutional Partners (RUSNANO, RVC, VEB) Regulatory environment Creation of service centers of legal assistance based on Techno park Support by the functional units of the Fund 15
BMT CSF Example. Management CSF Advisory Council Administration. Skolkovo Foundation CSF Scientific Council IP Centre CSF advisory council: responsibilities
Temporal leasing of the equipment to key collaborators/owners of buildings.
Major principles of the access and usage of the equipment.
Sector Head Sector Head Sector Head Sector Head R&D Director R&D Services. Customers Director. Services Educational and training courses Director. Training 16
17 BMT CSF. Example of general organisational structure Owners of infrastructure and buildings (Main collaborators) Skolkovo Fund. Cluster BMT. Technopark The Skolkovo Fund budget Staff Budget of main collaborators Existing equipment Existing best practices Infrustructure Fund subsidiary company Equipment Unified equipment facilities BMT cluster R&D R&D Budget: Service provider for Fund residents and Fund project companies Salaries for engineers and scientists working on the Fund equipment Training programmes Consumables for the Fund equipment Ph students, young researchers Budget form Fund project companies Skolkovo University. Skolkovo Open University Budget of resident companies The Skolkovo Fund budget 17
Example. CSF of BMT Cluster Among the potential CSF of BMT Cluster “Center for Structural Biology of membrane proteins and complexes“ and "Center of preclinical studies in the GLP standards” are the most elaborated Strategic co-investors In two pilot CSF identified. 18
The need for CSF establishment Implementation of development strategy
Center for Shared Facilities (Center of Excellence) - a key element in implementation of the strategy to create an innovative ecosystem by integrating services, education, research and innovation (commercialization) functions.
Effective use of the Fund assets in development of infrastructure
Effective use of time until 2014 to educate and train own qualified staff on the own equipment
CSF – qualified and high-liquid endowment of the future SIST
The reasons to start in 2011
Implementation of the development strategy- 011, announced and approved by the Council. Effective use of 2011 year budget.
The presence of a significant amount of infrastructural facilities (existing CSF, university laboratories and research centers) that possess the required competencie. Many companies and institutional investors launch a series of infrastructure projects. The optimal time to enter into alliances with major co-investors to create CSF and CeO centers.
The possibility of Russia Health Ministry participation
A long lapse of time required for delivery and installation of laboratory equipment. The need to order the equipment in the 1H 2011 In order to run it in the 4Q 2011.
BMT. System issues The requirement to coordinate and enhance state support of the
The leading countries actively support the creation of large BMT CSF as the organizer and the customer of innovations in the biomedicine and biopharmaceuticals
Example – EMBL (European Molecular Biology Laboratories) - Europe's leading interstate Centre for Molecular Biology and Biomedicine (includes 80 European research institutes and independent research groups)
To approve the concept to establish BMT CSF within the budget approved by the Fund in March 2011
To use the experience and best practices of CSF establishment of world's leading centers with help of Scientific Advisory Board.