BMT cluster. Report
Igor Goryanin. June 2011
Five key elements of the BMT innovation ecosystem
Community of
BMT residents
InfrastructuresRegulatory environment
Trainin...
Cooperation with Government of the Russian Federation
2
April 2001: Agreement, on cooperation
and coordination of joint ac...
Cooperation with institutional partners
3
•March 2011: Agreements with Infrastructural RVC
Venture Funds: Biofund RVC, Max...
Cooperation with regional biomedicine and biopharmaceutical
clusters
4
Feb 2011 Agreement of joining the BMT
Cluster to th...
Creating the «educational environment» within the BMT Сluster
5
Molecular genetics
Synthetic biology
System bioinformatics...
Educational Programs of BMT Cluster
6
March 2011 The final of the first session of
the qualifying competition program. The...
Projects of Biomed Cluster (20/6)
7
PROJECT TITLE FORESIGHT
PROJECT BUDGET,
MM RUB
AMOUNT FROM THE FUND
APPROVED, MM RUB (...
Projects of Biomed Cluster
8
PROJECT TITLE FORESIGHT COMPANY
PHARMACEUTICALS FROM THE MODIFIED BIOPOLYMER CARBOHYDRATES BI...
Projects of Biomed Cluster
9
PROJECT TITLE FORESIGHT COMPANY
DEVELOPMENT OF PHARMACEUTICALS FOR TREATMENT OF BACTERIAL AND...
10
Leading Universities
Major biomed and pharmaceutical companies
Regional Pharma Clusters
Ural PharmCluster (Yekaterinbur...
11
BMT Infrastructure is practically missing
CSFs and the BMT foresights. Equipment and competencies
Early development Lead optimization Preclinical Clinical - Registr...
Basic Principles of BMT CSF functioning
CSF research areas should be in the BMT foresights. CSF should provide services,
r...
Using existing competencies and adding novel ones.
Research and Development
Existing equipment New Equipment
BMT CSF
Exist...
ResidentsInfrastructuresUniversityInvestors
Regulatory
environment
20142012 - 20132011
Infrastructural Link-Labs (Project
...
BMT CSF Example. Management
CSF Advisory Council
CSF Director
Sector Head
Director R&D R&D
Educational and training course...
17
BMT CSF. Example of general organisational structure
Owners of infrastructure and buildings (Main collaborators)
The Sk...
Example. CSF of BMT Cluster
18
CSF
MAJOR
COLLABORATOR
PARTNERS
CO-INVESTOR, SUM OF
PROCEEDS IN 2011 FROM
CO-INVESTOR
SUM O...
The need for CSF establishment
Implementation of development strategy
▪ Center for Shared Facilities (Center of Excellence...
BMT. System issues
20
The requirement to coordinate and enhance state support of the
 The leading countries actively supp...
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бмт совет фонда Eng_goryanin

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бмт совет фонда Eng_goryanin

  1. 1. BMT cluster. Report Igor Goryanin. June 2011
  2. 2. Five key elements of the BMT innovation ecosystem Community of BMT residents InfrastructuresRegulatory environment Training / Educational Programs BMT Ecosystem. 5 4 3 2 1  Business incubators  Venture Capital Funds  Strategic industrial investors  Institutional Partners  Experts  Residents of the cluster (project companies)  Association of the resident’s partners (biomedical and pharmaceutical clusters)  Center for formalizing of IP Policy  Service Center of support of the Cluster residents (tax, legal, customs consultants)  Infrastructure link- laboratories  Centers for Shared Facilities (CSF), or Centers of Excellence (CoE)  R & D centers . Key partners  SIST (educational programs)  International traineeship  Internships  International Conferences/Roadshows Institutes of commercialization 1
  3. 3. Cooperation with Government of the Russian Federation 2 April 2001: Agreement, on cooperation and coordination of joint activities in the innovative development of health signed . •May 2011: Coordinating Council for Biomedical Technologies established The Ministry of Health and Social Development Ministry of Industry and Trade Status of relationship Development plan • March 2011: Working group (on coordination of joint activity in the field was established. •June 2011: Head of Cluster BMT elected to join the Working Group of the Commission on Modernization and Technological Development under the management of RF President . ▪ Joint expertise and support of innovative projects. ▪ Creation of a single register of the biomed projects.. ▪ Joint participation in the development of biomedical CSF’s and CEOs ▪ Unified information platforms Ministry of Economic Development February - May 2011: • Working Group on the development of the Law ”Cellular technology” • Platform "Medicines of the Future“ • Working Group “Drug manufacturing and R&D “ with the Commission on Modernization and Technical development under the management of RF President . ▪ Active participation and implementation of proposals of the Skolkovo Fund in Interdepartmental governmental Working Groups and committees on Biomedicine and biopharmaceuticals • Joint expertise and support of innovative projects •Joint participation in CSFs of Excellence •Coordination in priorities of innovation •Unified information platforms Partners
  4. 4. Cooperation with institutional partners 3 •March 2011: Agreements with Infrastructural RVC Venture Funds: Biofund RVC, Maxwell Biotech, BioProcess Capital Ventures - were signed. • May 2011: Joint expertise and structuring of 7 projects •Structuring of possible RVC participation . CSF "Preclinical studies with GLP standards” ▪ Co-financing of at least 3 projects in conjunction with RVC Funds. ▪ Participation of RVC Funds in one of CSF . JSC “RVC” JSC “RUSNANO” March 2011г: Agreement of creation Coordinating Council for Biomedical Technologies was signed. April - May 2011: Joint expertise and structuring of 3 projects with "ROSNANO April-May 2011: Jjoint (with IGB RAS), educational module, "System analysis of genomic data”, in collaboration with Cold Spring Harbor Laboratory (USA) ▪ Joint projects directory. ▪ Co-financing of at least 2 projects ▪ Starting with 2 joint educational practice- oriented modules . EMBL (European Molecular Biology Laboratories ) - European leading interstate Centre for Molecular Biology • April 2011: Agreement with the EMBL was signed. •April - May 2011: Consultations on the establishment of of EMBL R&D Institute in Skolkovo •April - May 2011: Participation of the EMBL in the CSF "Structural biology ” (in collaboration with the MIPT and ONEXIM Group) ▪ Participation of EMBL in CSF "Structural biology in collaboration with the MIPT and ONEXIM Group) ▪ EMBL R&D Institute ▪ in Skolkovo ▪ Joint training courses Status of relationship Development planPartners
  5. 5. Cooperation with regional biomedicine and biopharmaceutical clusters 4 Feb 2011 Agreement of joining the BMT Cluster to the Supervisory Board of the BFC “Severny“ signed Feb-May 2011 Joint educational program Apr-May 2011 Some of the BFC “Severny” participants got the resident status ▪ MIPT ▪ Chemrar ▪ PROTEK ▪ Pharmzashita ▪ Akrikhin Biopharmcluster “Severny” (MIPT) Status of relationship Participants Development plan ▪ Joint support for the best innovative projects of BFC “Severny” ▪ Using best practices (a business incubator, technopark, CSF, educational programs) i Ural Pharmcluster Kalugsky Pharmcluster Feb 2011 Agreement of the Supervisory Board of the Ural Pharmcluster signed Feb-May 2011 Examination of joint projects Apr 2011 Some of the Ural Pharmcluster participants get the resident status of the Fund ▪ Zavod Medsintez LLC ▪ IOS RAS ▪ Zavod Dizet LLC ▪ Unona Holding Company ▪ Joint support for the best innovative projects ▪ Using the regional practices May 2011 Agreement of joining the BMT Cluster to the Kalugsky Pharmcluster “Innovative biopharmaceutics” signed ▪ «Hemofarm» (STADA, Germany) ▪ «Berlin- Chemie/Menarini» (Italy) ▪ «Novo Nordisk» (Denmark) ▪ Astra Zeneca (UK) ▪ Joint support for the best innovative projects ▪ CSF in Nuclear Medicine Partners
  6. 6. Creating the «educational environment» within the BMT Сluster 5 Molecular genetics Synthetic biology System bioinformatics Cluster’s link- laboratories Cluster’s project companies (and their scientific partners) «Bortnic’s Fund» External special system specialized scientific knowledge providers “Skolkovo” University Biomedical faculty External personnel source for to organize the participation in the educational programs Educational module Providers of the systematic and scientific knowledge and practices Latest methodology of the Oncology diagnostics and therapy Latest medical cell technologies Cluster’s CSF’s Educational module Educational module Educational module Educational module practice practice practice practice practice Providers of the infrastructural platform for the lecture courses and the practice seminars holding on RUSNANO RVC Ministry of the Healthcare Provider of the consumers for the system knowledge BMT cluster Russian partners: the universities and he R&D centers Foreign university partners Providers of the best educational practices System biopharmaceutics Educational module practice
  7. 7. Educational Programs of BMT Cluster 6 March 2011 The final of the first session of the qualifying competition program. The program, “The Talent pool of young scientists of BMT Cluster “ (UMNIK-Skolkovets), in which 34 young professionals were selected,Bortnik’s Fund RUSNANO, Institute of Gene, Cold Spring Harbor Laboratory Status of relationship Development Plan March-May 2011 Practice-oriented educational module of “Statistical analysis of genomic data” is under testing May 2011 first students (BMT Cluster residents, RUSSNANO project companies, MIPT students, “Umnik-Skolkovets” graduates) ▪ Integration of the “Statistical analysis of genomic data” into CSF for “Medicine bioinformatics” of BMT Cluster ▪ Development. testing and, running of a new educational programs ASTRA ZENECA Co (UK) March 2011 BMT Cluster joining Supervisory Board of «Knowledge Vanguard» Virtual University, established by Astra Zeneca with the participation of RUSNANO, RVC, the Ministry of Health and Social Development of Russia April 2011: Applications expertise within the competition of research projects in cardiology and oncology •Conducting 2nd session of the "Talent Pool“ program •Choosing of the foreign universities-partners, the agreements signing for training of young scientists, graduates of "UMNIK-Skolkovets”, student exchange programs, development of internship programs and trainings Partners ▪ Completion of the contest and awarding the winners. ▪ Involvement of the winners in the educational and grant programs of BMT Cluster. ▪ Development of ASTRA ZENECA’s training programs in within the framework of the Coordinating Council of BMT Cluster and the Ministry of Health and Social Development of Russia
  8. 8. Projects of Biomed Cluster (20/6) 7 PROJECT TITLE FORESIGHT PROJECT BUDGET, MM RUB AMOUNT FROM THE FUND APPROVED, MM RUB (2011- 2013) AMOUNT OF 1ST TRANCHE, MM RUB SYNTHETIC PEPTIDE DRUGS BIO-PHARMA 795 675 170 PHOTOBIOLOGICAL MICROBIAL FCELLS BIO-INDUSTRIALS 600 420 90 DEVELOPMENT OF NOVEL ANTI-HYPOXIA- ADENOSINERGIC TECHNOLOGIES, DRUGS AND VACCINES FOR THE TREATMENT OF CANCER, INFECTIOUS DISEASES AND SEPSIS BIO-PHARMA 240 200 74 DEVELOPMENT OF AUTHENTIC MEDICINAL DRUGS FOR THE TREATMENT OF INFECTIOUS DISEASES OF VIRAL AETIOLOGY AND DEVELOPMENT OF DIAGNOSTIC METHODS FOR VIRUS DISEASES BIO-PHARMA 960 400 130 BIOTECHNOLOGY DETECTING AND NEUTRALIZING DANGEROUS INFECTIOUS AGENTS BIO-HEALTHCARE 420 220 77 DEVELOPMENT OF BIODEGRADABLE POLYMER INTRACORONARY IMPLANTS BIO-HEALTHCARE 105 69 21 TOTAL: 1984 562 FINANCING WERE APPROVED BY INVESTMENT COMMITTEE FOR SIX PROJECTS
  9. 9. Projects of Biomed Cluster 8 PROJECT TITLE FORESIGHT COMPANY PHARMACEUTICALS FROM THE MODIFIED BIOPOLYMER CARBOHYDRATES BIO-PHARMA VOSTOKFARM INNOVATIONS LLC TARGETED MULTIMODAL DIAGNOSTIC AND THERAPEUTIC AGENTS ON THE CARRIER OF "CORE-CARBON SHELL“ STRUCTURE BIO-PHARMA URAL NUCLEAR MEDICINE CENTER LLC DEVELOPMENT OF A NEW LINE OF BIOLOGICAL PRODUCTS ON THE BASIS OF CORD BLOOD STEM CELLS FOR TREATMENT OF ONCOLOGICAL AND HEMATOLOGICAL PATIENTS AFTER CHEMO-AND RADIOTHERAPY, USING THE METHODS OF IMMUNOMAGNETIC SEPARATION, CULTURING, GENETIC TESTING, EVALUATION OF TELOMERASE ACTIVITY, CRYOPRESERVATION BIO-HEALTHCARE CELLULAR INNOVATIONS LLC DEVELOPMENT AND IMPLEMENTATION OF A PERSONALIZED DIAGNOSIS AND TREATMENT OF ONCOLOGICAL DISEASES BIO-HEALTHCARE UNIVERSAL BIOSYSTEMS LLC DEVELOPMENT AND COMMERCIALIZATION OF INNOVATIVE TARGETED DRUG FOR THE TREATMENT OF KIDNEY CANCER BIO-PHARMA ONKOMAKS LLC LACTOFERRIN AND OTHER REGULATORY AND THERAPEUTIC HUMAN PROTEINS FROM TRANSGENIC GOATS’ MILK. DEVELOPING SCIENTIFIC AND TECHNOLOGICAL BASIS FOR A BIO-TECH TRANSGENIC INDUSTRY IN RUSSIA BIO-HEALTHCARE TRANSGENFARM LLC DEVELOPMENT OF A MODEL OF VENOUS VALVE PROSTHESIS BIO-HEALTHCARE SPC AMFION LLC FIFTEEN PROJECTS RECEIVED PARTICIPANT CERTIFICATE
  10. 10. Projects of Biomed Cluster 9 PROJECT TITLE FORESIGHT COMPANY DEVELOPMENT OF PHARMACEUTICALS FOR TREATMENT OF BACTERIAL AND FUNGAL INFECTIONS ON THE BASIS OF THE PATENTED ANALOG NATURAL PEPTIDE LL-37 BIO-PHARMA BIOCHART LLC DEVELOPMENT AND COMMERCIALIZATION OF NOVEL DRUG FOR MULTIDRUGRESISTANT TUBERCULOSIS TREATMENT BIO-PHARMA INFEKTEKS LLC DEVELOPMENT OF NEW PHARMACEUTICAL COMPOSITIONS AND DRUGS FOR THE TREATMENT OF NEUROLOGICAL DISEASES BIO-PHARMA LEKSYSTEMS LLC DEVELOPMENT OF THE NEW DRUGS BASED ON DERIVATIVES OF N-ACYL BIOGENIC AMINES AND THEIR ANALOGUES BIO-PHARMA FARMALLIANCE LLC ANTIVIRAL DRUGS DEVELOPMENT BASED ON INHIBITION OF MATRIX PROTEINS BIO-PHARMA QUANTUM PHARMACEUTICALS DEVELOPMENT OF PHARMACEUTICAL COMPOSITION (CMX-157) FOR TREATMENT AND PREVENTION OF HIV INFECTION INCLUDING HIGH-RESISTANT FORMS BIO-PHARMA HELIX VENTURES Information platform for biomedical research BIOINFORMATICS BIOSOFT.RU LLC DEVELOPMENT OF BRAIN-COMPUTER INTERFACE TECHNOLOGY FOR PROSTHETIC LIMBS AND MANIPULATORS CONTROL BIO-HEALTHCARE INNOVATION TECHNOLOGIES LLC FIFTEEN PROJECTS RECEIVED PARTICIPANT CERTIFICATE
  11. 11. 10 Leading Universities Major biomed and pharmaceutical companies Regional Pharma Clusters Ural PharmCluster (Yekaterinburg) Pharm Cluster Severny (North of Moscow) Institutional partners Collaboration with key partners Agreement will be signed Jun, 17 ($15M) Agreement will be signed soon (15FTE in R&D M&S Centre) General MoU General MoU
  12. 12. 11 BMT Infrastructure is practically missing
  13. 13. CSFs and the BMT foresights. Equipment and competencies Early development Lead optimization Preclinical Clinical - Registration and launch Transgenomic and postgenomic technologies Foresight. Biomedicine and Bio- pharmaceutics Complex modeling and simulation. Biomedical Informatics «Proteomics , and other omics Preclinical and clinical studies. P4 Medicine. Cancer ) Foresight Bioinformatics Preclinical. GLPStructural Biology» Directed evolution Artificial ecosystems Scaling upй Foresight Industrial biotechnologies Synthetic biology Regenerative medicine « AB and other novel therapies Infection diseases» 12
  14. 14. Basic Principles of BMT CSF functioning CSF research areas should be in the BMT foresights. CSF should provide services, research and educational programmes 1) Capital expenses for major consumables and equipment are covered by the Fund. Operational budget to be provided by residents companies and external customers. Infrastructure facilities, the equipment and maintenance services of CSFs are to be 100% owned by the Skolkovo Foundation or/and its wholly owned subsidiary. 3) Residents of the Skolkovo should have a first right to use CSFs services and competencies. There should be a strong demand for competences of CSF 4) CSF should provide and maintain excellence in access to modern biomedical equipment, research infrastructure, highly qualified staff, and services on the world level 5) 2) CSF establishment in the field of interest is supported by independent scientific experts6) 13
  15. 15. Using existing competencies and adding novel ones. Research and Development Existing equipment New Equipment BMT CSF Existing methodologies and techniques Staff Skills and experience Commercialisation experience Existing scientific collaborations Project companies. CSF customers New qualified staff Key partners Effective management Innovation projects Educational and retraining programmes 14 Services
  16. 16. ResidentsInfrastructuresUniversityInvestors Regulatory environment 20142012 - 20132011 Infrastructural Link-Labs (Project based). Centers for Shared Facilities (CSF) or CoE Functioning of the BMT infrastructural Ecosystem Educational programs based on the project companies community and infrastructure partners Creation of Departments of Skolkovo University Projects Link-labs are based on project companies activities Part of the R & D centers establishes on the basis of Centers for Shared FacilitiesR & D centers with key partners Develop and implement the modules of special lectures and seminars (including "remote web – courses”) Co-investors and strategic projects partners Venture Capital Funds Institutional Partners (RUSNANO, RVC, VEB) Creating a network of business incubators Long-term relationships with strategic investors Support by the functional units of the Fund Creation of service centers of legal assistance based on Techno park BMT CSF development pipeline 15
  17. 17. BMT CSF Example. Management CSF Advisory Council CSF Director Sector Head Director R&D R&D Educational and training courses Sector Head Sector Head Sector Head CSF Scientific Council Director. Training Director. Services Services. Customers Skolkovo Foundation Administration. IP Centre CSF advisory council: responsibilities • Budget control. Finance • Administration. Planning. • R&D and other services management • Co-investment and other grants management Collaborative Agreements include • Temporal leasing of the equipment to key collaborators/owners of buildings. • Major principles of the access and usage of the equipment. 16
  18. 18. 17 BMT CSF. Example of general organisational structure Owners of infrastructure and buildings (Main collaborators) The Skolkovo Fund budget Fund subsidiary company R&D Budget: Salaries for engineers and scientists working on the Fund equipment Equipment BMT cluster Consumables for the Fund equipment Budget form Fund project companies Budget of resident companies Budget of main collaboratorsExisting equipment Unified equipment facilities Staff Existing best practicesInfrustructure Skolkovo Fund. Cluster BMT. Technopark Skolkovo University. Skolkovo Open University R&D Service provider for Fund residents and Fund project companies Training programmes Ph students, young researchers The Skolkovo Fund budget 17
  19. 19. Example. CSF of BMT Cluster 18 CSF MAJOR COLLABORATOR PARTNERS CO-INVESTOR, SUM OF PROCEEDS IN 2011 FROM CO-INVESTOR SUM OF PROCEEDS FROM SKOLKOVO FOUNDATION IN 2011 Structural Biology. Membrane protein and their complexes MIPT - Institute of Structural Biology (IBS, France) - EMBL, Grenoble - Research Centre (FZ-Juelich, Germany) - SCRIPPS Institute , (USA) - ONEKSIM group ONEXIM GROUP: 100 MM RUB MIPT: 160 MM RUB 200 MM RUB Pre-clinical research. GLP standards IBC RAS (Pushchino) - Astra Zeneca - RVC JSC - ITEB RAS (Pushchino) - Ministry of health, Russia RVC JSC:150 MM RUB 150 MM RUB Among the potential CSF of BMT Cluster “Center for Structural Biology of membrane proteins and complexes“ and "Center of preclinical studies in the GLP standards” are the most elaborated Strategic co-investors In two pilot CSF identified.
  20. 20. The need for CSF establishment Implementation of development strategy ▪ Center for Shared Facilities (Center of Excellence) - a key element in implementation of the strategy to create an innovative ecosystem by integrating services, education, research and innovation (commercialization) functions. ▪ Effective use of the Fund assets in development of infrastructure ▪ Effective use of time until 2014 to educate and train own qualified staff on the own equipment ▪ CSF – qualified and high-liquid endowment of the future SIST The reasons to start in 2011 ▪ Implementation of the development strategy- 011, announced and approved by the Council. Effective use of 2011 year budget. ▪ The presence of a significant amount of infrastructural facilities (existing CSF, university laboratories and research centers) that possess the required competencie. Many companies and institutional investors launch a series of infrastructure projects. The optimal time to enter into alliances with major co-investors to create CSF and CeO centers. ▪ Strong demand from Skolkovoparticipants ▪ The possibility of Russia Health Ministry participation ▪ A long lapse of time required for delivery and installation of laboratory equipment. The need to order the equipment in the 1H 2011 In order to run it in the 4Q 2011. 19
  21. 21. BMT. System issues 20 The requirement to coordinate and enhance state support of the  The leading countries actively support the creation of large BMT CSF as the organizer and the customer of innovations in the biomedicine and biopharmaceuticals  Example – EMBL (European Molecular Biology Laboratories) - Europe's leading interstate Centre for Molecular Biology and Biomedicine (includes 80 European research institutes and independent research groups) Proposals  To approve the concept to establish BMT CSF within the budget approved by the Fund in March 2011  To use the experience and best practices of CSF establishment of world's leading centers with help of Scientific Advisory Board.
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