Inflammation is a key player in bone resorption Role for omega-3 in reducing bone and muscle loss with ageing and reduce fracture risk, higher BMD in omega-3 users
Lee = high doses (2.7g) reduces NSAID intake
Our results mirror other controlled studies that compared ibuprofen and omega-3 EFAs demonstrating equivalent effect in reducing arthritic pain. Omega-3 EFA fish oil supplements appear to be a safer alternative to NSAIDs for treatment of nonsurgical neck or back pain in this selective group.
Specialist clinical nutrition: an essential adjunct to successful manual therapy
Specialist clinical nutrition: an essential
adjunct to successful manual therapy
Dr Nina Bailey
BSc (Hons) MSc PhD
• Igennus Healthcare Nutrition are a clinical nutrition
specialist providing bespoke support for inflammatory
• You don’t need to be a nutrition specialist to make a
difference to your client’s health!
• Igennus has established relationships with over 50
chiropractors, osteopaths, acupuncturists,
reflexologists, massage therapists, personal trainers
and fitness instructors…….
• Dr Raymond Perrin (PhD) osteopath, neuroscientist and
pioneer of The ‘Perrin Technique’
• The Perrin Technique is a unique lymphatic drainage
technique that treats CFS – all Perrin CFS patients are
recommended to take 1-2g of Igennus EPA
• Igennus collaborates with 96 ‘Perrin Practitioners’ who
use this protocol successfully
• Robin Pauc – neurologist and chiropractor, founder of the UK
renowned Tinsley House Clinic for childhood developmental
• Robin Pauc regularly recommends Igennus’ products as an
addition to his treatment programmes:
• Igennus EPA used by Dave Scott U.S. triathlete and six-time Ironman
Triathlon World Champion
• Numerous personal trainers use Igennus’ products over generic oils as part
of their sports nutrition package - clients get better results:
Joint and bone support
Reduced oxidative stress
Supports energy requirements
Supports lean muscle mass/fat burn
Supports recovery time and performance
Our biggest practitioner accounts are manual/physical
therapists NOT nutrition specialists….
Why do they choose us?
Premium quality ingredients
Scientifically proven formulations
Niche therapeutic target
Expert support team
Highest purity and lowest contaminants
They really work!
• Posture issues
• Muscle spasm
All result in nerve and muscle damage = short/long term reduced mobility,
pain and subsequent secondary issues
But most importantly the science……..
Top reason to see a manual therapist:
Pain due to:
• Pain = inflammation = pain – signal that damage is present and protects
• Process of inflammation must be tightly regulated in the body. If not,
can lead to unnecessary inflammation and exacerbate pre-existing
issues or initiate new ones otherwise non-problematic
• Unnecessary inflammation / inability to switch off inflammation =
chronic pain and reduced mobility
• PLUS very high risk of inflammation ‘spreading’ systemically = increased
risk of inflammatory disease
• Medication – but like fighting an Australian bush fire with oil - if
you use enough may put out the flame in the short term but long
term MUCH worse
• Many pharmaceuticals also have potentially detrimental side
effects (i.e. COX-2 inhibitors)
• Manual therapy addresses the muscle and nerve issues and
restores function to the body to reduce pain and promote mobility
• But without addressing the route cause of unnecessary
inflammation leads to long term issues and numerous secondary
What is inflammation?
– the normal response of a tissue to injury
– triggered by a number of causes including infection, invading
pathogens (such as bacteria or viruses), trauma or compromised blood
– desirable defence mechanism with undesirable side effects
– normal inflammatory response has an on/off switch
– in chronic inflammation there are issues with down-regulating signals
The key to regulating inflammation is through the
modulation of eicosanoids:
• Pro-inflammatory eicosanoids drive the immune and inflammatory
• Anti-inflammatory eicosanoids act to end the process
• Overproduction of pro-inflammatory products or reduced
production of anti-inflammatory products can result in continued
production of inflammatory products – the hallmark of silent
Regulating eicosanoids through diet
• Eicosanoids are derived from a group of polyunsaturated fats
known as omega-6 and omega-3
• The ratio of omega-6 to omega-3 in the diet influences the type
of eicosanoid produced
• The ratio of omega-6 to omega-3 is commonly associated with
• The ratio of KEY omega-6 and omega-3 fats AA and EPA gives us a
direct indication of inflammatory health
• The AA to EPA ratio is an indication of the balance between pro-
inflammatory and anti-inflammatory eicosanoids
• High AA and low EPA levels will drive the inflammatory response and the
subsequent failure to resolve inflammation may increase susceptibility to
the development of chronic, low-grade, inflammation-based diseases
AA to EPA ratio - biomarker of inflammatory status
0 % 4% 8% 12%
Omega-3 index* - biomarker of cardiovascular health
*Harris & Von Schacky, 2004
The role of diet and lifestyle in modulating inflammation
• Triggers from chronic altered diet and psycho-emotional stress
negatively influence the resolution step of the inflammatory
• Failure to resolve inflammation increases susceptibility to the
development of chronic, low-grade, inflammation-based
diseases due to the constant activation of both the HPA-axis
and innate immune system (Bosma-den Boer et al., 2012)
Resoleomics - the process of inflammation resolutionInflammatoryresponse
Initiation Resolution Termination
Eicosanoid switch Stop signal
Bosma-den Boer MM, van Wetten ML, Pruimboom L: Chronic inflammatory diseases are stimulated by current lifestyle:
how diet, stress levels and medication prevent our body from recovering. Nutrition & metabolism 2012, 9:32
•Oily fish via diet in decline
•A major 1st world dietary
•Supplementation of food
necessary – milk, spreads
Omegas in food
Omegas in dietary
Omega-3 transition to medicine
Increasing health problems relating to weight issues
Flock MR, Rogers CJ, Prabhu KS, Kris-Etherton PM: Immunometabolic role of long-
chain omega-3 fatty acids in obesity-induced inflammation. Diabetes/metabolism
research and reviews 2013, 29:431-445.
Makki K, Froguel P, Wolowczuk I: Adipose Tissue in Obesity-Related Inflammation
and Insulin Resistance: Cells, Cytokines, and Chemokines. ISRN inflammation 2013,
Titos E, Claria J: Omega-3-derived mediators counteract obesity-induced adipose
tissue inflammation. Prostaglandins & other lipid mediators 2013, 107:77-84.
White PJ, Marette A: Is omega-3 key to unlocking inflammation in obesity?
Diabetologia 2006, 49:1999-2001.
White PJ, Marette A: Potential role of omega-3-derived resolution mediators in
metabolic inflammation. Immunology and cell biology 2014, 92:324-330.
Omega-3 and bone health
Mangano KM, Sahni S, Kerstetter JE, Kenny AM, Hannan MT: Polyunsaturated fatty
acids and their relation with bone and muscle health in adults. Current
osteoporosis reports 2013, 11:203-212.
McMahon MS: Beneficial effect of omega-3 fatty acids on bone metabolism.
Orthopedics 2012, 35:735-736.
Rousseau JH, Kleppinger A, Kenny AM: Self-reported dietary intake of omega-3
fatty acids and association with bone and lower extremity function. Journal of the
American Geriatrics Society 2009, 57:1781-1788.
Saidenberg Kermanac'h N, Bessis N, Cohen-Solal M, De Vernejoul MC, Boissier MC:
Osteoprotegerin and inflammation. European cytokine network 2002, 13:144-153.
Inflammation, omega-3 and rheumatoid arthritis
Curtis CL, Rees SG, Little CB, Flannery CR, Hughes CE, Wilson C, Dent CM, Otterness
IG, Harwood JL, Caterson B: Pathologic indicators of degradation and inflammation
in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.
Arthritis and rheumatism 2002, 46:1544-1553.
Sperling RI: Dietary omega-3 fatty acids: effects on lipid mediators of inflammation
and rheumatoid arthritis. Rheumatic diseases clinics of North America 1991,
Lee YH, Bae SC, Song GG: Omega-3 polyunsaturated fatty acids and the treatment
of rheumatoid arthritis: a meta-analysis. Archives of medical research 2012,
Omega-3 and pain
Maroon JC, Bost JW: Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for
discogenic pain. Surgical neurology 2006, 65:326-331.
• AA and EPA contents of cell membranes can be altered through
oral administration of omega-3 EPA
• Increasing EPA levels results in a changed pattern of production of
• Changing the fatty acid composition of cell membranes also affects
immune function and pathways
– changes in membrane structure
– cell signalling
– gene expression of cells and products involved in the inflammatory
cascade and pain signalling
• As health practitioners, you are perfectly placed to guide patients
toward natural co-therapies
• Route of inflammation may not just be due to pain/injury issue,
as consultation/client history may reveal:
• High stress
• Neurological disorder
• Poor diet and lifestyle
• Low mood
• Inflammation is a key driver of a myriad of diseases/conditions
Thus, addressing high levels of inflammation by restoring
AA to EPA ratio and increasing the omega-3 index will
Risk of modern illness
Measuring inflammation and tracking progress
• Blood spot fatty acid profiling
Omega-6 to omega-3 ratio
AA to EPA ratio
• Knowing a client’s baseline omega-3 index allows effective dosing to
increase omega-3 index and reduce the AA to EPA ratio
Omega-3 index Dose required Body weight Minimum dose
Base line Target (mg/kg) (kg) (g)
3 8 0.0222 89 1.98
4 8 0.0172 89 1.53
6 8 0.0072 89 0.64
You don’t need to be a nutrition specialist to
make a difference to your clients’ health
Our biggest practitioner accounts are manual
therapists NOT nutrition specialists….
Expertly formulated EPA supplements to suit all ages and needs
Scientifically proven co-therapies to support long term health
Technical support from MSc Nutrition Specialists
Literature and personalised support for your clients
Fatty acid blood profiling service allows a bespoke and effective
Practitioner Scheme benefits:
A personalised referral code (i.e. SMITH25)
Highest commission on direct orders
Best discount for your clients
Free 1-2-1 training with our highly qualified nutrition team
Free promotional materials for your clients
Free profile feature on our website
Over 45% profit on trade orders
Instant 30 days free credit
PLUS additional 20% off your first trade order (effective profit
up to 57%)
Bosma-den Boer MM, van Wetten ML, Pruimboom L: Chronic inflammatory diseases are
stimulated by current lifestyle: how diet, stress levels and medication prevent our body from
recovering. Nutrition & metabolism 2012, 9:32.
Flock MR, Skulas-Ray AC, Harris WS, Etherton TD, Fleming JA, Kris-Etherton PM: Determinants of
erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response
randomized controlled trial. Journal of the American Heart Association 2013, 2:e000513.
Harris WS, Von Schacky C: The Omega-3 Index: a new risk factor for death from coronary heart
disease? Preventive medicine 2004, 39:212-220.
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