IEA - Expressão gênica: é complexo mesmo ou só estão faltando partes?
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IEA - Expressão gênica: é complexo mesmo ou só estão faltando partes?

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Evento organizado pelo Instituto de Estudos Avançados da USP, Polo Ribeirão Preto (IEA-RP). ...

Evento organizado pelo Instituto de Estudos Avançados da USP, Polo Ribeirão Preto (IEA-RP).
Mais informações: http://www.iearp.blogspot.com.br/2012/09/perspectivas-sobre-aplicacoes-de_18.html

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IEA - Expressão gênica: é complexo mesmo ou só estão faltando partes? IEA - Expressão gênica: é complexo mesmo ou só estão faltando partes? Presentation Transcript

  • USP – University of Sao Paulo LabPIB – Laboratório de Processamento de Informação Biológica http://labpib.fmrp.usp.br Prof. Dr. Vêncio rvencio@usp.brGene Expression: is it really complex or is itjust missing parts ?
  • Who are we ?
  • Who are we ?
  • Complex Systems
  • Complex Systems
  • Complex Systems
  • 2+2>4
  • 2+2>4
  • 2+2=51) Do we know all parts to sum them up ?2) What are the interactions among parts ?
  • Biological Motivation Joyce & Palsson, Nat Rev Mol Cell Biol (2006)
  • Biological Motivation ncRNA RNA-protein interaction RNA-RNA interaction structuromics 2012 update on Joyce & Palsson, Nat Rev Mol Cell Biol (2006)
  • Biological Motivation ncRNA RNA-protein interaction RNA-RNA interaction structuromics 2012 update on Joyce & Palsson, Nat Rev Mol Cell Biol (2006)
  • Biological Motivation … today ncRNA RNA-protein interaction RNA-RNA interaction structuromics 2012 update on Joyce & Palsson, Nat Rev Mol Cell Biol (2006)
  • ~ 5 μmfrom wikipedias “halobacterium” entry ~ 1 cm Bonneau et al., Cell (2007)from webmineral.com Mineralogy Databases “halite” entry
  • Bonneau et al., Cell (2007)
  • Bonneau et al., Cell (2007)
  • 2+2=51) Do we know all parts to sum them up ?2) What are the interactions among parts ? Bonneau et al., Cell (2007)
  • 2+2=51) Do we know all parts to sum them up ? No, ncRNAs are still missing2) What are the interactions among parts ? Some are known, but protein-RNA are missing Bonneau et al., Cell (2007)
  • ncRNA discovery by high-throughput sequencing RNA-seq Wang et al., Nat Rev Gen (2009)
  • ncRNA discovery by high-throughput sequencing RNA-seq Felipe ten Caten, Diego Martinez, Lívia Zaramela - PhD Candidates
  • ncRNA discovery by high-throughput sequencing RNA-seq Felipe ten Caten, Diego Martinez, Lívia Zaramela - PhD Candidates
  • ncRNA discovery by high-throughput sequencing RNA-seqThere is a transcriptbut there is no protein
  • Protein-RNA interaction discovery by RIP-SeqVery similar to knownChip-seq but for RNAinteractions from wikipedias “ChIP-sequencing” entry Lívia Zaramela - PhD Candidate
  • Protein-RNA interaction discovery by RIP-Seq Support Vectors Marcos Abraão - PhD Candidate
  • So... back to the original question is it really complex or is it just missing parts?
  • So... back to the original question is it really complex or is it just missing parts? Probably both. http://www.systemsbiology.org.au/
  • USP – University of Sao PauloLabPIB – Laboratório de Processamento de Informação Biológicahttp://labpib.fmrp.usp.brProf. Dr. Vênciorvencio@usp.br
  • USP – University of Sao Paulo LabPIB – Laboratório de Processamento de Informação Biológica http://labpib.fmrp.usp.br Prof. Dr. Vêncio rvencio@usp.brThank you for your attention! “ Simplicity is a great virtue but it requires hard work to achieve it and education to appreciate it. And to make matters worse: complexity sells better ” -- E. Dijkstra.