Oral Flora and its role of indifferent oral pathologiesIyad Abou Rabii
Harmful Effects of the Normal Flora       1-       Bacterial synergism between a member of the normal flora and a         ...
Harmful Effects of the Normal Flora       2. Competition for nutrients Bacteria in the gastrointestinal tract must        ...
Harmful Effects of the Normal Flora       3. The normal flora may be agents of disease. Members of the normal           fl...
Dental Plaque The classic biofilm that involves components of the normal flora of the oral  cavity is the formation of de...
Dental Plaque These accumulations subject the teeth and gingival tissues to high  concentrations of bacterial metabolites...
Dental Plaque Dental plaque, consists of bacterial cells (60-70% the volume of the  plaque), salivary polymers, and bacte...
Dental Plaque The dominant bacterial species in dental plaque are Streptococcus sanguis Streptococcus mutans,          ...
Dental Plaque Plaque formation is initiated by a weak attachment of the streptococcal  cells to salivary glycoproteins fo...
Dental Plaque  An enzyme on the cell surface of Streptococcus mutans,   glycosyl transferase, is involved in initial atta...
Page  11
Pathologies caused by Oral Flora Dental caries: destruction of enamel, dentin or cementum of teeth  – bacteria in plaque ...
Dental Caries Dental Caries is the destruction of the enamel, dentin or cementum of  teeth due to bacterial activities. ...
Dental Caries Streptococcus mutans and Streptococcus sanguis are most consistently  been associated with the initiation o...
Dental caries : Streptococcus mutans Streptococcus mutans in particular has a number of physiological and  biochemical pr...
Dental caries : other pathogens Streptococcus mutans appears to be important in the initiation of dental  caries because ...
Periodontal Diseases Periodontal Diseases are bacterial infections that affect the supporting  structures of the teeth (g...
Periodontal Diseases Diseases that are confined to the gingiva usually do not lead to loss of  teeth, but there are other...
Page  19
Copyright notice   Feel free to use this PowerPoint presentation for your personal,   educational and business.   Do   • M...
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Oral flora2 18 nov-11-1

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Oral flora2 18 nov-11-1

  1. 1. Oral Flora and its role of indifferent oral pathologiesIyad Abou Rabii
  2. 2. Harmful Effects of the Normal Flora 1- Bacterial synergism between a member of the normal flora and a potential pathogen. • A member of the normal flora may supply a vitamin or some other growth factor that a pathogen needs in order to grow. This is called cross-feeding between microbes. • "staph-protected infections" phenomena occurs when a penicillin-resistant staphylococcus that is a component of the normal flora shares its drug resistance with pathogens that are otherwise susceptible to the drug.Page  2
  3. 3. Harmful Effects of the Normal Flora 2. Competition for nutrients Bacteria in the gastrointestinal tract must absorb some of the hosts nutrients for their own needs. • So some nutrient(s) may be lost to the host. • Germ-free animals are known to grow more rapidly and efficiently than conventional animals. Incorporating antibiotics into the food of swine, cows and poultry make animal grows faster and can therefore be marketed earlier. (a cause of bacterial antibiotic resistance).Page  3
  4. 4. Harmful Effects of the Normal Flora 3. The normal flora may be agents of disease. Members of the normal flora may cause endogenous disease if they reach a site or tissue where they cannot be restricted or tolerated by the host defenses. Many of the normal flora are potential pathogens, and if they gain access to a compromised tissue , or host defense is decreased, disease may result. (Candida Albicans)Page  4
  5. 5. Dental Plaque The classic biofilm that involves components of the normal flora of the oral cavity is the formation of dental plaque on the teeth. Plaque is a naturally- constructed biofilm, in which the consortia of bacteria may reach a thickness of 300-500 cells on the surfaces of the teeth.Page  5
  6. 6. Dental Plaque These accumulations subject the teeth and gingival tissues to high concentrations of bacterial metabolites, which result in dental disease.Page  6
  7. 7. Dental Plaque Dental plaque, consists of bacterial cells (60-70% the volume of the plaque), salivary polymers, and bacterial extracellular products. These accumulations subject the teeth and gingival tissues to high concentrations of bacterial metabolites, which result in dental and periodontal diseases.Page  7
  8. 8. Dental Plaque The dominant bacterial species in dental plaque are Streptococcus sanguis Streptococcus mutans, Streptococcus mutansPage  8
  9. 9. Dental Plaque Plaque formation is initiated by a weak attachment of the streptococcal cells to salivary glycoproteins forming a pellicle on the surface of the teeth. This is followed by a stronger attachment by means of extracellular sticky polymers of glucose (glucans) which are synthesized by the bacteria from dietary sugars (principally sucrose).Page  9
  10. 10. Dental Plaque  An enzyme on the cell surface of Streptococcus mutans, glycosyl transferase, is involved in initial attachment of the bacterial cells to the tooth surface and in the conversion of sucrose to dextran polymers (glucans) which form plaque. Dental plaque, scanning electron micrograph illustrating the diversity of microbes in plaque.Page  10
  11. 11. Page  11
  12. 12. Pathologies caused by Oral Flora Dental caries: destruction of enamel, dentin or cementum of teeth – bacteria in plaque produce lactic acid Streptococcus mutans – Lactic acid demineralizes enamel Periodontal disease – Gingiva, cementum, periodontal membrane, alveolar bone – Rich in anaerobesPage  12
  13. 13. Dental Caries Dental Caries is the destruction of the enamel, dentin or cementum of teeth due to bacterial activities. Caries are initiated by direct demineralization of the enamel of teeth due to lactic acid and other organic acids which accumulate in dental plaque. Lactic acid bacteria in the plaque produce lactic acid from the fermentation of sugars and other carbohydrates in the diet of the host.Page  13
  14. 14. Dental Caries Streptococcus mutans and Streptococcus sanguis are most consistently been associated with the initiation of dental caries, but other lactic acid bacteria are probably involved as well. These organisms normally colonize the occlusal fissures and contact points between the teeth, and this correlates with the incidence of decay on these surfaces.Page  14
  15. 15. Dental caries : Streptococcus mutans Streptococcus mutans in particular has a number of physiological and biochemical properties which implicate it in the initiation of dental caries. 1. It is a regular component of the normal oral flora of humans that can form a thin film on the tooth called the enamel pellicle. 2. It contains a cell-bound protein, glycosyl transferase, that serves an adhesin for attachment to the tooth, and as an enzyme that polymerizes dietary sugars into glucans that leads to the formation of plaque. 3. It produces lactic acid from the utilization of dietary carbohydrate which demineralizes tooth enamel. S. mutans produces more lactic acid and is more acid-tolerant than most other streptococci. 4. It stores polysaccharides made from dietary sugars which can be utilized as reserve carbon and energy sources for production of lactic acid.Page  15
  16. 16. Dental caries : other pathogens Streptococcus mutans appears to be important in the initiation of dental caries because its activities lead to colonization of the tooth surfaces, plaque formation, and localized demineralization of tooth enamel. It is not however, the only cause of dental decay. After initial weakening of the enamel, various oral bacteria gain access to interior regions of the tooth. – Lactobacilli, – Actinomyces, – and various proteolytic bacteriaare secondary invaders that contribute to the progression of the lesions.Page  16
  17. 17. Periodontal Diseases Periodontal Diseases are bacterial infections that affect the supporting structures of the teeth (gingiva, cementum, periodontal membrane and alveolar bone). The most common form, gingivitis, is an inflammatory condition of the gums. It is associated with accumulations of bacterial plaque in the area. Increased populations of Actinomyces have been found, and they have been suggested as the cause.Page  17
  18. 18. Periodontal Diseases Diseases that are confined to the gingiva usually do not lead to loss of teeth, but there are other more serious forms of periodontal disease that affect periodontal membrane and alveolar bone resulting in tooth loss. Bacteria in these lesions are very complex populations consisting of – Gram-positive organisms (including Actinomyces and streptococci) – Gram-negative organisms (including spirochetes and Bacteroides). The mechanisms of tissue destruction in periodontal disease are not clearly defined but hydrolytic enzymes, endotoxins, and other toxic bacterial metabolites seem to be involved.Page  18
  19. 19. Page  19
  20. 20. Copyright notice Feel free to use this PowerPoint presentation for your personal, educational and business. Do • Make a copy for backups on your harddrive or local network. • Use the presentation for your presentations and projects. • Print hand outs or other promotional items. Don‘t • Make it available on a website, portal or social network website for download. (Incl. groups, file sharing networks, Slideshare etc.) • Edit or modify the downloaded presentation and claim / pass off as your own work. All copyright and intellectual property rights, without limitation, are retained by Dr. Iyad Abou Rabii. By downloading and using this presentatione, you agree to this statement. Please feel free to contact me, if you do have any questions about usage. Dr. Iyad Abou Rabii Iyad.abou.rabii@qudent.edu.saPage  20
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