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Dea project
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Dea project

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  • 1. Modélisation des ÉchangesdAlcool entre Salive et Sang (étude préliminaire) ABOU RABII. I, VINCENT. F, BACONNIER. P, BESSARD. G Laboratoire TIMC-IMAG Université Joseph Fourier Grenoble I Laboratoire Pharmacologie CHU Grenoble.
  • 2. Le modèle Dose absorbée %S 100-%S Secteur salivaire Tube digestif K2 Sang K1 K3 Elimination Métab olisme
  • 3. Le modèledG(t) Q1* (t) kgs * G(t) k bg * B(t) dtdS(t) vmax * S(t) k gs *G(t) (k0s ksb ) * S(t) dt k m S(t)dB(t) Q2 * (t) ksb * S(t) kbg * (t) dt
  • 4. Résultats (II): contamination 8 7 Dé gl uti tio n Co ntamin atio n 6 5 [Alcool] (g/l) 4 3 2 1 0 0 60 12 0 18 0 24 0 Te mps (min)
  • 5. Résultats (III): effets du rinçage  prise sans rejet avec rejet 8 8 Sa ns rin çag e Avec rin çag e 6 6 [Alcool] (g/l) [Alcool] (g/l) 4 4 2 2 0 0 0 60 12 0 18 0 24 0 0 60 Te mps (min) Te mps (min)
  • 6. Résultats (IV): paramètres Secteur Tube salivaire digestif Sang KS_B KTD_S KEL KTD_S (min -1 ) KS_ B (min -1 ) KEL (min -1 )PB (#1) 0.015 0.010 0.038 CAT 0.011 0.016 0.082 (#2) VIN 0.012 0.023 0.128 (#3)
  • 7. Résultats (V): simulation 2 Données exp érimentales Concentration salivaire (g/litre) Modélisation 1,5 1 0,5 0 0 50 100 150 200 Temps (minutes)
  • 8. Dispositif QEDimprégnation insertion dans ledu coton-tige corps du test lecture du résultat

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