A short introduction
<ul><li>Phylogenetic tree </li></ul><ul><li>A. nidulans  specific </li></ul><ul><li>A. nidulans  as a model organism </li>...
<ul><li>Largest Phylum of fungi (over 64.000) species </li></ul><ul><li>Defining sexual feature: the ascus. </li></ul>
<ul><li>Filamentous fungi </li></ul><ul><li>Fission rather then budding </li></ul>Binary Fission Budding
<ul><ul><li>Cleistothecium </li></ul></ul>plate of medium with A nidulans culture Order: Eurotiales The green and blue molds
<ul><li>Aggresive colonization strategies </li></ul><ul><li>Adaptable to extreme environmental conditions </li></ul><ul><u...
<ul><li>Highly aerobic </li></ul><ul><li>Oligotrophy </li></ul><ul><li>Commercially the most important fungi </li></ul>Cit...
<ul><li>Creates a cleistothecium with ascus inside in the sexual cycle </li></ul><ul><li>Filamentous </li></ul><ul><li>Cel...
<ul><li>Synonym:  Aspergillus nidulellus </li></ul><ul><li>Teleomorph:  Emericella nidulans </li></ul><ul><li>Anamorph:  A...
http://www.nature.com/nrg/journal/v3/n9/box/nrg889_BX1.html
<ul><li>Why  A. nidulans  has been chosen as a model organism </li></ul>http://www.broadinstitute.org/annotation/genome/as...
http://www.nature.com/nprot/journal/v2/n4/fig_tab/nprot.2007.112_F1.html
http://www.nature.com/nprot/journal/v2/n4/fig_tab/nprot.2007.112_F1.html
http://www.nature.com/nprot/journal/v2/n4/fig_tab/nprot.2007.112_F1.html
<ul><li>Pulmonary infection </li></ul><ul><li>Cutaneous aspergillosis </li></ul><ul><li>Maxillary sinus disease </li></ul>...
<ul><li>Cell biology </li></ul><ul><li>Gene regulation </li></ul><ul><li>Mitosis </li></ul><ul><li>Intracellular functions...
<ul><li>Sexual cycle </li></ul><ul><li>8 chromosomes </li></ul><ul><li>At least 9 cell types </li></ul><ul><li>Research fo...
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A. nidulans iGEM Wageningen UR

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Transcript of "A. nidulans iGEM Wageningen UR"

  1. 1. A short introduction
  2. 2. <ul><li>Phylogenetic tree </li></ul><ul><li>A. nidulans specific </li></ul><ul><li>A. nidulans as a model organism </li></ul><ul><li>Reproduction cycles </li></ul><ul><li>A. nidulans vs. A. niger </li></ul>
  3. 3. <ul><li>Largest Phylum of fungi (over 64.000) species </li></ul><ul><li>Defining sexual feature: the ascus. </li></ul>
  4. 4. <ul><li>Filamentous fungi </li></ul><ul><li>Fission rather then budding </li></ul>Binary Fission Budding
  5. 5. <ul><ul><li>Cleistothecium </li></ul></ul>plate of medium with A nidulans culture Order: Eurotiales The green and blue molds
  6. 6. <ul><li>Aggresive colonization strategies </li></ul><ul><li>Adaptable to extreme environmental conditions </li></ul><ul><ul><li>For A. nidulans : </li></ul></ul><ul><ul><ul><li>Temperature 10-45 o C </li></ul></ul></ul><ul><ul><ul><li>pH 2.5-11 </li></ul></ul></ul><ul><ul><ul><li>NaCl concentration <4.0 M </li></ul></ul></ul>
  7. 7. <ul><li>Highly aerobic </li></ul><ul><li>Oligotrophy </li></ul><ul><li>Commercially the most important fungi </li></ul>Citric acid http://aspergillusblog.blogspot.com/2008/09/aspergillus-produced-most-of-worlds.html http://en.wikipedia.org/wiki/Aspergillus
  8. 8. <ul><li>Creates a cleistothecium with ascus inside in the sexual cycle </li></ul><ul><li>Filamentous </li></ul><ul><li>Cells divide by fission </li></ul><ul><li>Green cultures </li></ul><ul><li>Can live under ‘extreme’ conditions </li></ul><ul><li>Highly aerobic </li></ul><ul><li>oligotroph </li></ul>
  9. 9. <ul><li>Synonym: Aspergillus nidulellus </li></ul><ul><li>Teleomorph: Emericella nidulans </li></ul><ul><li>Anamorph: Aspergillus nidulans </li></ul><ul><li>Homothallic </li></ul><ul><li>Sexual, asexual and parasexual reproduction </li></ul><ul><li>Model organism </li></ul>
  10. 10. http://www.nature.com/nrg/journal/v3/n9/box/nrg889_BX1.html
  11. 11. <ul><li>Why A. nidulans has been chosen as a model organism </li></ul>http://www.broadinstitute.org/annotation/genome/aspergillus_group/MultiHome.html
  12. 12. http://www.nature.com/nprot/journal/v2/n4/fig_tab/nprot.2007.112_F1.html
  13. 13. http://www.nature.com/nprot/journal/v2/n4/fig_tab/nprot.2007.112_F1.html
  14. 14. http://www.nature.com/nprot/journal/v2/n4/fig_tab/nprot.2007.112_F1.html
  15. 15. <ul><li>Pulmonary infection </li></ul><ul><li>Cutaneous aspergillosis </li></ul><ul><li>Maxillary sinus disease </li></ul><ul><li>Guttural pouch mycosis (in horses) </li></ul><ul><li>Cerebral abscess </li></ul><ul><li>Endophtalmitis </li></ul><ul><li>Osteomyelitis </li></ul><ul><li>Superficial infections </li></ul><ul><li>Disseminated infections </li></ul>The atlas of clinical fungi p486 http://www.doctorfungus.org/thefungi/Aspergillus_nidulans.php
  16. 16. <ul><li>Cell biology </li></ul><ul><li>Gene regulation </li></ul><ul><li>Mitosis </li></ul><ul><li>Intracellular functions of mitotic motors </li></ul><ul><li>Carbon & nitrogen regulation </li></ul><ul><li>Cell cycle </li></ul><ul><li>Fungal protein secretion </li></ul><ul><li>Gene regulation </li></ul><ul><li>Cell wall biosynthesis </li></ul><ul><li>Cell morphology </li></ul><ul><li>Carbon metabolism </li></ul><ul><li>Nutrient transport </li></ul><ul><li>Effects of environmental factors on enzyme production </li></ul><ul><li>Industrial use </li></ul>http://www.broadinstitute.org/annotation/genome/aspergillus_group/GenomeDescriptions.html
  17. 17. <ul><li>Sexual cycle </li></ul><ul><li>8 chromosomes </li></ul><ul><li>At least 9 cell types </li></ul><ul><li>Research focused on gene control </li></ul><ul><li>No sexual cycle </li></ul><ul><li>8 chromosomes </li></ul><ul><li>Research focused on protein production and excretion </li></ul>www.broadinstitute.org/annotation/fungi/fgi/sample_whitepaper.pdf nature.com/nbt/journal/v25/n2/fig_tab/nbt1282_F2.html www.broadinstitute.org/annotation/genome/aspergillus_group/GenomeDescriptions.html
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