Anatomy of
cranial nerves
introduction
Dr Hytham Nafady
CNS development
The neural tube
• The neural tube gives rise to the CNS
(including the brain & spinal cord).
• The brain stem & spinal cor...
The neural crest
• Gives rise to the peripheral nervous system (peripheral
nerves & sensory & autonomic ganglia).
1. Pseud...
• The anterior neuropore:
• The closure of the anterior neuropore gives rise to
the lamina terminalis.
Failure of closure ...
Branchial arches
N Site Supply
Somatic motorSomatic motor 3, 4, 6
& 12
Lie medially Striate muscles
•Eye
•Tongue.
BranchiomericBranchiomeri...
N Site Supply
VisceralVisceral
sensorysensory
9 &
10
Lie lateral to the
visceral motor
Chemo & baro
receptors
7 & 9 Taste ...
Ganglia and nuclei
Ganglia:
• Aggregation of cell bodies in a peripheral
nerve.
Nuclei:
• Aggregation of cell bodies insid...
Motor, parasympathetic & sensory
nuclei
Motor nuclei contain the cell bodies of lower
motor neurons
Parasympathetic
nuclei...
Parasympathetic & sensory ganglia
Sensory ganglia contain cell bodies of the
peripheral sensory (somatic or visceral) nerv...
Autonomic ganglia (ganglia with synapses).
Sensory ganglia (ganglia without synapses).
Head & neck ganglia
Parasympathetic fibers
Taste fibers
Cranial nerve attachments
Cranial nerves
attached to the
forebrain
(telencephalon) 1-Olfactory nerve.
(diencephalon) 2-Optic nerve.
Cranial nerves a...
Cranial nerve nuclei
Cross section through the medulla
Medial structures
• Pyramid.
• Medial leminscus.
• Hypoglossal nucleus.
Lateral stuctures
• Olive.
• Nucleus ambiguus.
• Dorsal motor nucleus of vagus.
• Solitary nucleus.
• Vestibular nuclei.
M...
Cross section at the pons
Medial structures
• Genu of facial nerve.
• Abducens nucleus.
• Abducens nerve.
• Medial longitudinal fasciculus.
• Medial...
Lateral structures
• Cochlear nuclei.
• Vestibular nuclei.
• Facial nucleus.
• Spinal leminscus.
• Facial nerve.
• Facial ...
Cross section at the midbrain
Functional Classification of CN
• Spinal Nerve classification
– General Efferent or Afferent: serve general motor, sensory...
Types of nerve fibers within cranial nerves
Direction of impulse:
• motor (efferent) or
• sensory (afferent).
The mode of ...
7Functional Types
General Somatic Efferent GSE Muscles from somites (skeletal, extraocular,
glossal)
General Visceral Effe...
3-4-6
Somatic motor fibers – oculomotor, trochlear and abducens nuclei:
Extrinsic ocular muscles are derived from pre-otic...
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
Introduction to anatomy of the cranial nerves
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Introduction to anatomy of the cranial nerves

  1. 1. Anatomy of cranial nerves introduction Dr Hytham Nafady
  2. 2. CNS development
  3. 3. The neural tube • The neural tube gives rise to the CNS (including the brain & spinal cord). • The brain stem & spinal cord have: 1. An alar plate that gives rise to the sensory neurons. 2. A basal plate that gives rise to sensory neurons. • The neural tube gives rise to 3 primary vesicles, which develop into 5 secondary vesicles
  4. 4. The neural crest • Gives rise to the peripheral nervous system (peripheral nerves & sensory & autonomic ganglia). 1. Pseudounipolar ganglion cells of the spinal & cranial nerves ganglia. 2. Schwan cells (which elaborate the myelin sheath). 3. Multipolar ganglion cells of the autonomic ganglia. 4. Leptomeninges (the pia-arachnoid). 5. Chromaffin cells of the suprarenal medulla. 6. Melanocytes. 7. Odontoblasts (which elaborate predentine). 8. Aortopulmonary septum of the heart. 9. Parafollicular cells (calcitonin producing C cells). 10.Skeletal & connective tissue component of the pharyngeal arches.
  5. 5. • The anterior neuropore: • The closure of the anterior neuropore gives rise to the lamina terminalis. Failure of closure of the anterior neuropore gives rise to anencephaly Failure of closure of the posterior neuropore gives rise to spina bifida
  6. 6. Branchial arches
  7. 7. N Site Supply Somatic motorSomatic motor 3, 4, 6 & 12 Lie medially Striate muscles •Eye •Tongue. BranchiomericBranchiomeric motormotor 5, 7, 9 & 10 Initially develop in the periventricular grey matter then migrate ventrolaterally Striate muscles •Jaw. •Face. •Pharynx. •Larynx. Visceral motorVisceral motor 3, 7, 9 & 10 glands &viscera •Head & neck. •Thorax. •Abdomen.
  8. 8. N Site Supply VisceralVisceral sensorysensory 9 & 10 Lie lateral to the visceral motor Chemo & baro receptors 7 & 9 Taste receptors (tongue). SomaticSomatic sensorysensory 5 Initially develop in the periventricular grey matter then migrate ventrolaterally Proprioreceptor, nocireceptors and thermo-receptors (in the skin, muscles & joints of the head) SpecialSpecial sensorysensory 8 Lie most lateral in the periventricular zone. Ear. Cochlea. Vesibule.
  9. 9. Ganglia and nuclei Ganglia: • Aggregation of cell bodies in a peripheral nerve. Nuclei: • Aggregation of cell bodies inside the CNS. • Ganglia are peripheral and nuclei are central. • Basal ganglia is a misnomer (basal nuclei).
  10. 10. Motor, parasympathetic & sensory nuclei Motor nuclei contain the cell bodies of lower motor neurons Parasympathetic nuclei contain the cell bodies of the pre- ganglionic para-symathetic fibers Sensory nuclei (somatic or visceral) contain the cell bodies of the secondary sensory neurons
  11. 11. Parasympathetic & sensory ganglia Sensory ganglia contain cell bodies of the peripheral sensory (somatic or visceral) nerve. • It also contain somatic motor fibers which pass without relay. Autonomic ganglia contain the cell bodies of the postganglionic parasympathetic fibers. • It also contains visceral sensory fibers which pass without relay.
  12. 12. Autonomic ganglia (ganglia with synapses). Sensory ganglia (ganglia without synapses).
  13. 13. Head & neck ganglia
  14. 14. Parasympathetic fibers
  15. 15. Taste fibers
  16. 16. Cranial nerve attachments
  17. 17. Cranial nerves attached to the forebrain (telencephalon) 1-Olfactory nerve. (diencephalon) 2-Optic nerve. Cranial nerves attached to the midbrain (mesencephalon) 3-Oculomotor. 4-Trochlear. Cranial nerves attached to the hindbrain (rhombencephalon) 5-Trigeminal 6-Abducent. 7-Facial. 8-Vestibulocochlear. 9-Glosspharyngeal. 10-Vagus. 11-Accessory. 12-Hypoglossal.
  18. 18. Cranial nerve nuclei
  19. 19. Cross section through the medulla
  20. 20. Medial structures • Pyramid. • Medial leminscus. • Hypoglossal nucleus.
  21. 21. Lateral stuctures • Olive. • Nucleus ambiguus. • Dorsal motor nucleus of vagus. • Solitary nucleus. • Vestibular nuclei. More lateral • Spinal lemeniscus. • Trigeminal tract & spinal nucleus. • Inferior cerebellar peduncle.
  22. 22. Cross section at the pons
  23. 23. Medial structures • Genu of facial nerve. • Abducens nucleus. • Abducens nerve. • Medial longitudinal fasciculus. • Medial leminscus. • Corticospinal tract.
  24. 24. Lateral structures • Cochlear nuclei. • Vestibular nuclei. • Facial nucleus. • Spinal leminscus. • Facial nerve. • Facial nucleus.
  25. 25. Cross section at the midbrain
  26. 26. Functional Classification of CN • Spinal Nerve classification – General Efferent or Afferent: serve general motor, sensory. • Cranial Nerves classification – Receptor type: • General - just like spinal nerves • Special –Use special receptors and neurons to serve additional specialized functions – Signal type • Efferent – Sensory • Afferent - Motor – Voluntary or reflexive? • Somatic. Innervate somatic muscles (muscles that arise from the soma in the embryological stage – voluntary muscle control) • Visceral. Innervate visceral structures.
  27. 27. Types of nerve fibers within cranial nerves Direction of impulse: • motor (efferent) or • sensory (afferent). The mode of control: • voluntary or • involuntary. The embryological origin of the structure innervated: • Somatic (somite, body wall) or • Visceral (gut tube, internal organs). The distribution in the body: • General (widespread) or • Special (restricted to the head and neck).
  28. 28. 7Functional Types General Somatic Efferent GSE Muscles from somites (skeletal, extraocular, glossal) General Visceral Efferent GVE Smooth muscles of visceral Organs Special Visceral Efferent SVE Muscles of face, palate, mouth, pharynx and larynx (excludes eye & tongue muscles). Special Visceral Afferent SVA visceral sensation of taste from tongue Olfaction from Nose General Visceral Afferent GVA sensory innervation from visceral organs General Somatic Afferent GSA Sensory innervation from muscles, skin, ligament and joints Special Somatic Afferent SSA special sensations of vision from retina and audition and equilibrium from inner ear
  29. 29. 3-4-6 Somatic motor fibers – oculomotor, trochlear and abducens nuclei: Extrinsic ocular muscles are derived from pre-otic somites. Motor fibers innervating them, therefore, are somatic motor fibres and nuclei are somatic motor nuclei. Upper motor neuron input to nuclei of each side is bilateral. Nuclei also receive fibers from medial longitudinal fasciculus for control of eye movements. Oculomotor nucleus: periaqueductal grey matter of midbrain, near midline, immediately ventral to aqueduct of Sylvius. Axons pass ventrally to emerge in the interpeduncular fossa. Trochlear nucleus: in periaqueductal grey matter of midbrain, below oculomotor nuclei. Axons pass dorsally, decussating within midbrain dorsal to aqueduct. Abducens nucleus: in pons, related to VII motor nucleus
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