Major neurotransmitters: glutamate (excitatory) and GABA (inhibitory)Damage results in weakness, with loss of voluntary movements especially fine, skilled movements, but preservation of other forms of movements including segments reflexesThey both (1-2) receive input from several motor and sensory cortical areas and project back to the cerebral cortex via the thalamus. They integrate and modulate motor activity primarily through the cerebral cortex and direct activation pathways.
Final common pathway – many motor units through which all activities in the motor system must act
central causes : Cerebral palsy as cerebellar or atonic diplegiaCP, , syndromes as Down syndrome or Prader Willi syndrome, neurodegenerative or neurometabolic disorders
Neuromotor disorder general view: make it easy
NEURO-MOTOR SYSTEMProf Dr Hussein AbdeldayemProf and Chief of Ped Neurology Unit,alex university