Your SlideShare is downloading. ×
Leukemia For FM
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×

Introducing the official SlideShare app

Stunning, full-screen experience for iPhone and Android

Text the download link to your phone

Standard text messaging rates apply

Leukemia For FM

359
views

Published on

for Family Medicine doctotrs, G Pediatrician, Medical students

for Family Medicine doctotrs, G Pediatrician, Medical students

Published in: Health & Medicine

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
359
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
23
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. . Leukemia. In Pediatrics for FM By:Prof Dr Hussein Abdeldayem, MD Prof of Pediatrics, Alex , Egypt
  • 2. -:Definition LeukemiaMalignant invasion Arrest of WBC Appearance of of precursor of division Blast cells in WBC to Bone marrow peripheral blood
  • 3. Prevalence Commonest malignancy In Male < female Age 2 -8 years(childhood (30%
  • 4. Etiology Genetic & Consideration & Drugs Chromosomal Ionizing radiation .Abnormalities chemicals -:.E.g -:.e.g down syndrome alkylating agent Identical twins E.g.:- Chernobyl heavy metals &Sibling of leukemia patients
  • 5. ‫أول حالة مثبتة علميً.. السرطان ينتقل من الم‬ ‫ا‬ ‫90/01/31‬ ‫للجنين‬ ‫أظهرت الختبارات المعملية إصابة الرضيعة باللوكيميا، وشرح الوالد بأن الم‬ ‫•‬ ‫توفيت بذات المرض بعد ثلثة أشهر من ولدتها.‬ ‫واكتشف الباحثون باستخدام تقنية "البصمة الوراثية" أن دم الم والطفلة يشتركان‬ ‫•‬ ‫في ذات الخليا السرطانية المتعدية، ما يعني بأن المصدر واحد حيث انتقلت تلك‬ ‫الخليا من الم إلى الجنين عبر المشيمة.‬‫وقالت بروفيسور ميل غريف، التي قادت البحث المنشور في "محاضر الكاديمية‬ ‫•‬ ‫القومية للعلوم" وأوردته صحيفة "التلغراف"، إنها "حالة نادرة بشكل استثنائي."‬ ‫وأضاف معلقة: "نعتقد الخليا السرطانية للم عبرت عن طريق المشيمة إلى‬ ‫•‬ ‫الجنين أثناء النموه ونجحت في الستزراع لنها كانت غير مرئية لجهاز‬ ‫المناعة."‬
  • 6. ClassificationAcute chronic97% 3%
  • 7. Acute Mixed LineageLymphoid Myeloid 4% 75% 20% & Undifferentiated 1%
  • 8. Acute lymphoblastic leukemiaDisease of early lymphoid cells &commonest type of leukemia in pediatric age group
  • 9. Classification of ALL
  • 10. – French – American British classificationcell size 2- chromatid shape 3- Nucleoli -1L1 L2 L3
  • 11. Immunological Markers immunotypingB cell leukemia T cell leukemia 80% 20%
  • 12. Manifestation of A L L
  • 13. Manifestations of malignance BM Non BMGeneral infiltration Infiltration
  • 14. GeneralWeight Low grade Lassitude loss fever
  • 15. BM invasion RBC Platelets WBC -In Anemia Hge fection -Pete Chae Bleeding Repeate Easy -Tachy SeriousPallor Purpura Of Fever ulcers -in fatigue cardia Hge .ecchym MM fection
  • 16. Non BM invasion Infiltration Extra Of medullary Lymphoid Infiltration system CNS Hge -Lymph -Genitosplenomegaly hepatomegaly & CVS adenopathy Focal urinary Brain lesion
  • 17. Investigation
  • 18. Laboratory Peripheral findings Blood picture -:Platelets RBC:- -:WBC or↓ or N ↑ ↓ ↓ + + + Blast cells Normocytic MainlyAbn Function normochromic lymphocyte
  • 19. BM examination RBC Megakaryocytes WBCMothers ↓ ↑ ↓ Mainly blasts (80 -100%)
  • 20. Radiological findings -:chest Skeletal surveymediastinal mass CT Scan
  • 21. prognosis Good Prognostic Factors includes Leukocytic Age CNS count(years 7- 3) involvement 3 mm/10,000<
  • 22. Cause of death Infiltrationinfection hemorrhage of Vital organs
  • 23. -:Treatment .I Supportive Therapy General care-:Psychological Prevent .1 Vaccination Emotional infection (killed vaccine ) support Nutrition .2 Treat Anemia .3
  • 24. II. Specific Therapy Aiming at Induction of Maintenance remission Of Prevent & remission RelapseCNS protection For 3 years
  • 25. .IIIBone MarrowTransplantation
  • 26. Thank You