Stepping Stones - Mikhail Shapiro - H+ Summit @ Harvard

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Stepping Stones - Mikhail Shapiro - H+ Summit @ Harvard

  1. 1. Stepping  Stones: Ge#ng  to  enhancement  by  focusing  on  disease Mikhail  G.  Shapiro,  PhD H+  Summit  2010 ©  2010  Mikhail  Shapiro
  2. 2. Brain-­‐machine  interfaces Brain  reading  and  uploading Enhanced  learning Greater  cogniEve  abiliEes Greater  sensory  powers Need  for  mulEple  technology  breakthrougs High  performance  requirements High  safety  requirements Long  and  expensive  investment  proposiEon ©  2010  Mikhail  Shapiro
  3. 3. Brain-­‐machine  interfaces Brain  reading  and  uploading Enhanced  learning Greater  cogniEve  abiliEes Greater  sensory  powers Schizophrenia Spinal  Cord  Injury Alzheimer’s Depression Blindness Deafness Epilepsy Parkinson’s ©  2010  Mikhail  Shapiro
  4. 4. Brain-­‐machine  interfaces Locked  in  syndrome ALS Spinal  Cord  Injury ©  2010  Mikhail  Shapiro
  5. 5. ©  2010  Mikhail  Shapiro John  Donoghue  et  al,  Brown  University
  6. 6. ‘mouse’ array ©  2010  Mikhail  Shapiro Serruya  et  al,  Nature  (2001)
  7. 7. ©  2010  Mikhail  Shapiro Hockberg  et  al,  Nature  (2006)
  8. 8. Reliability Speed,  Low  effort Natural  feeling Super-­‐enablement 2D  cursor  &  click Wheelchair  control   Invisible  electronics Must  Deliver Unaended  operaEon Basic  limb  control Fine  limb  control  (eg   digits) MulE-­‐dimensional   device  control Healthy  people Very  late-­‐stage  ALS,   Low  quad,   Locked-­‐in Paraplegia,   Market ALS,  High  Quad Tens  of  thousands Amputees Hundreds  to  few  thousand Hundreds  of  thousands millions CompeMng  Technologies Voice EMG EMG TAP JoysMck Tongue,   EMG,  PNS sip&puff,  etc. EEG NIRS ©  2010  Mikhail  Shapiro
  9. 9. Brain  Reading  and  Uploading Parkinson’s Epilepsy Rare  GeneEc  Diseases ©  2010  Mikhail  Shapiro
  10. 10. [ ] ©  2010  Mikhail  Shapiro
  11. 11. InspiraEon:  Hemoglobin  in  fMRI Heeger,  Ress.  Nat.  Rev.  Neurosci  (2002) ©  2010  Mikhail  Shapiro
  12. 12. HOH Ligand Fe3+ Dopamine HOH Fe3+ Shapiro  MG  et  al.,  Nature  Biotechnology  (2010) ©  2010  Mikhail  Shapiro Alan  Jasanoff,  Frances  Arnold,  Robert  Langer,  Gil  Westmeyer
  13. 13. Adrenoleukodystrophy ©  2010  Mikhail  Shapiro Car$er  N  et  al.,  Science  (2009)
  14. 14. Rare  GeneEc  Diseases Parkinson’s Schizophrenia Epilepsy ©  2010  Mikhail  Shapiro
  15. 15. Enhanced  learning Alzheimer’s Learning  disability Stroke ©  2010  Mikhail  Shapiro
  16. 16. ©  2010  Mikhail  Shapiro Williams  and  Eskandar.,  Nature  Neuroscience  (2006)
  17. 17. Greater  sensory  powers Deafness Blindness ©  2010  Mikhail  Shapiro
  18. 18. Blindness Deafness ©  2010  Mikhail  Shapiro Boyden  ES,  et  al.  Nature  Neuroscience  (2005) Bi  et  al.  Neuron  (2005)
  19. 19. Success  factors  for  commercial  clinical  venture   •  Addresses  a  disease  not  well  served  by  exisEng  technology •  High-­‐quality  science  demonstraEng  key  scienEfic  principles •  Technology  is  a  good  fit  for  the  problem  at  hand •  Big  clinical  market  either  iniEally  or  clear  path  to  one •  Ability  to  get  to  clinical  trials  within  1-­‐2  years,  market  3-­‐5  years •  The  usual:  best  people,  strong  backing,  great  management ©  2010  Mikhail  Shapiro
  20. 20. Brain-­‐machine  interfaces Brain  reading  and  uploading Enhanced  learning Greater  cogniEve  abiliEes Greater  sensory  powers Schizophrenia Spinal  Cord  Injury Alzheimer’s Depression Blindness Deafness Epilepsy Parkinson’s ©  2010  Mikhail  Shapiro
  21. 21. Thank  You mikhail@thirdrockventures.com ©  2010  Mikhail  Shapiro

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