Humansin2020<br />Ramez Naam<br />@ramez<br />
Three Ingredients<br />
Motivation is Medical<br />
Acceptable<br />Human Baseline<br />
?<br />Human Baseline<br />Questionable!<br />
External != Internal<br />
?<br />?<br />Human Baseline<br />
The Power to Heal=The Power to Enhance<br />
Our Population is Aging<br />
A Worldwide Phenomenon<br />
Disability as a Function of Age<br />
Lost With Age<br />
A Very Large Motivator<br />
Order:  Trillions of $’s<br />
Ten Thousand Dollars<br />
One Million Dollars<br />
One Billion Dollars<br />
One Trillion Dollars<br />You Are Here<br />
So What?<br />
Opportunity?<br />
Knowledge<br />
Understanding<br />
Human Construction<br />
Goal:  100,000 Genomes by 2020<br />
2020: $100 Genome<br />
Millions of Genomes Sequenced<br />
Millions of Individual Humans<br />
Every Mammalian Species<br />
Lots of Data to Mine<br />
What Will We Find?<br />
Knowing is Half the Battle<br />
The Other Half is Doing<br />
If the Genome is Digital<br />
Can We Edit It?<br />
Sometimes<br />
Some Challenges<br />
Immune Response<br />
Cancer (from retroviral vectors)<br />
Number of Cells Changed<br />
Progress<br />
Strength & Endurance: IGF-1, Myostatin, PPAR-Delta<br />
Oxygen Capacity: EPO<br />
“About half the emails I get now are from athletes”<br />       - Gene Therapy Researcher Lee Sweeney<br />
More Provocative Changes are Likely Possible<br />
In Summary<br />
We Are Approaching the Day of the Editable Genome<br />
Humansin2020<br />Ramez Naam<br />@ramez<br />
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Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

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Ramez Naam
Humanity 2020: The Next 10 Years of Human Development

The decade between 2010 and 2020 will be a small but significant step in the development of human enhancement technology, with tremendous numbers of new discoveries in genetics fueled by the continuing exponential drop in gene sequencing cost, commercial availability of a new generation of cognitive enhancers and the first plausible aging inhibitors, likely advances in genetic reprogramming of embryos and of mature humans, and continued progress in prosthetics, imaging, sports enhancement, and numerous other areas. Science and technology will have made significant strides in empowering individuals to be smarter, stronger, faster, and longer lived than ever before.

Computer scientist Ramez Naam, author of More Than Human: Embracing the Promise of Human Enhancement, and winner of the 2005 H.G. Wells Award for Contributions to Transhumanism will give a guided tour of the 10 year horizons across the board of human enhancement.

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  • Dawkins: Biology in One Word: Digital
  • Venter: Most Important Research Tool: The Computer
  • George Church
  • Venter, artificial life = Gene Printing
  • Belgian Blue Bull – mutated form of MyostatinMouse on Lower Right – PPAR-Delta
  • EeroMantyranta, 1964 cross country skiing gold medalist, had a mutation of his EPO genes that led to greater endurance
  • Humanity 2020: The Next 10 Years of Human Development - Ramez Naam - H+ Summit @ Harvard

    1. 1. Humansin2020<br />Ramez Naam<br />@ramez<br />
    2. 2. Three Ingredients<br />
    3. 3.
    4. 4. Motivation is Medical<br />
    5. 5. Acceptable<br />Human Baseline<br />
    6. 6. ?<br />Human Baseline<br />Questionable!<br />
    7. 7.
    8. 8. External != Internal<br />
    9. 9. ?<br />?<br />Human Baseline<br />
    10. 10. The Power to Heal=The Power to Enhance<br />
    11. 11. Our Population is Aging<br />
    12. 12. A Worldwide Phenomenon<br />
    13. 13.
    14. 14. Disability as a Function of Age<br />
    15. 15. Lost With Age<br />
    16. 16. A Very Large Motivator<br />
    17. 17. Order: Trillions of $’s<br />
    18. 18. Ten Thousand Dollars<br />
    19. 19. One Million Dollars<br />
    20. 20. One Billion Dollars<br />
    21. 21. One Trillion Dollars<br />You Are Here<br />
    22. 22.
    23. 23. So What?<br />
    24. 24. Opportunity?<br />
    25. 25. Knowledge<br />
    26. 26. Understanding<br />
    27. 27. Human Construction<br />
    28. 28.
    29. 29.
    30. 30.
    31. 31.
    32. 32. Goal: 100,000 Genomes by 2020<br />
    33. 33. 2020: $100 Genome<br />
    34. 34. Millions of Genomes Sequenced<br />
    35. 35. Millions of Individual Humans<br />
    36. 36. Every Mammalian Species<br />
    37. 37. Lots of Data to Mine<br />
    38. 38.
    39. 39. What Will We Find?<br />
    40. 40.
    41. 41. Knowing is Half the Battle<br />
    42. 42. The Other Half is Doing<br />
    43. 43. If the Genome is Digital<br />
    44. 44. Can We Edit It?<br />
    45. 45. Sometimes<br />
    46. 46.
    47. 47.
    48. 48.
    49. 49.
    50. 50. Some Challenges<br />
    51. 51. Immune Response<br />
    52. 52. Cancer (from retroviral vectors)<br />
    53. 53. Number of Cells Changed<br />
    54. 54. Progress<br />
    55. 55.
    56. 56.
    57. 57.
    58. 58. Strength & Endurance: IGF-1, Myostatin, PPAR-Delta<br />
    59. 59. Oxygen Capacity: EPO<br />
    60. 60. “About half the emails I get now are from athletes”<br /> - Gene Therapy Researcher Lee Sweeney<br />
    61. 61. More Provocative Changes are Likely Possible<br />
    62. 62. In Summary<br />
    63. 63. We Are Approaching the Day of the Editable Genome<br />
    64. 64.
    65. 65. Humansin2020<br />Ramez Naam<br />@ramez<br />
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