ISB Prosperity Partnership Presentation by John Aitchison

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ISB Prosperity Partnership Presentation by John Aitchison

  1. 1. Institute for Systems BiologyJohn Aitchison, Ph.D.ProfessorVP, Director for Integrative Biology
  2. 2. Three Pillars of ISB Systems Biology Collaborations Partnerships Commercial Spinouts Stewardship Education
  3. 3. Systems Biology• Different in concept• Demands cycle of innovation• Potential to Drive All Biological Research • New research opportunities • Medicine – Predictive, Preventive, Personalized and Participatory – P4 medicine • Commercial opportunities
  4. 4. Biology is a systems problem • Neutrophil – chasing down bacteria to eat it• A system is any collection of interacting parts with emergent behavior.• Emergence is when the whole is greater than the sum of the parts.
  5. 5. What is a System?• A system is any collection of interacting parts with emergent behavior.• Emergence is when the whole is greater than the sum of the parts.
  6. 6. What is a System?• A system is any collection of interacting parts with emergent behavior.• Emergence is when the whole is greater than the sum of the parts.
  7. 7. Biological Systems Are Self Organizing Cells: dynamic networks of interacting components, with millions of local interactions (systems)
  8. 8. Traditional approaches study a singlegene/RNA/protein at a time DNA RNA Protein Time Single gene But there are tens of thousands of genes/RNA/proteins!
  9. 9. Systems Biology DNA RNA Protein Driven by computation and technology A holistic view
  10. 10. Systems Biology drives a cycle of innovation Biological Information Biology And Insight Cross-Disciplinary Systems Biology seeks to Culture address important and complex Team Science problems in biology that have previously been intractable.
  11. 11. Systems Biology drives a cycle of innovation Biology Cross-Disciplinary Culture Team Science
  12. 12. Three Major Research Thrusts at ISB Medical Research Sustainability Health Care (Global Health) (BioEnergy) (P4 Medicine) Solving Complex Problems Requires a Systems Approach ISB is attacking these problems through partnerships. Drive systems biology and apply in these major areas
  13. 13. Three Major Research Thrusts at ISB Medical Research Sustainability Health Care (Global Health) (BioEnergy) (P4 Medicine)
  14. 14. The fundamental challenge:How can we understand the emergent macroscopic properties of thesystem from its parts and their interactions? Analogy: circuit diagram
  15. 15. Systems Biology and MedicineDynamic, Responsive Molecular Networks • How do perturbations (disease) propagate through a network? • How can we alter the network of a diseased individual and revert it to ‘normal’?
  16. 16. Systems biology to understand complex responses - of cells - and of pathogens and hostsStimulus PROGRAM of response(fatty acids) ~40% of the genes change in expression
  17. 17. Systems biology to understand complex responses - of cells - and of pathogens and hostsPathogen PROGRAM of response( ~40% of the genes change in expression ~50% of human genes change expression upon infection with Vaccinia virus (Grinde et al., J. Virol, 4: 24 2007)
  18. 18. Application of systems biology to vaccine development To identify predictors of vaccine immunogenicity (signatures) To understand the molecular networks leading to a protective response Edward Jenner 1796 To re-engineer the response with adjuvants
  19. 19. ISB-SBRI Partnership
  20. 20. ISB-SBRI PartnershipCombine Complementary Strengths Infectious disease research Systems biology Immunology TechnologyRevolutionize scientific approaches to vaccine and drug development for global infectious diseaseUnique, Creative and Productive Environment shared facilities, enhanced scientific exchange new research opportunities - funding
  21. 21. Solving Complex Problems Requires a Systems Approach Medical Research Sustainability Health Care (Global Health) (BioEnergy) (P4 Medicine)
  22. 22. Solving Complex Problems Requires a Systems Approach Medical Research Sustainability Health Care (Global Health) (BioEnergy) (P4 Medicine)
  23. 23. Dynamics of a Brain Network in Prion Neurodegenerative Disease Prion accumulation network
  24. 24. Dynamics of a Brain Network in Prion Neurodegenerative Disease Prion accumulation network300 genes encode the core prion disease response—map to 4 major networksNetwork dynamics explains all disease pathophysiologyProfound implications for diagnostics and therapy – P4
  25. 25. Predictive, Personalized, Preventive and Participatory (P4) MedicineGenome sequence; multiparameter measurements; computation 26
  26. 26. P4 Medicine• Predictive • Probabilistic health history • DNA sequence & Regular multi- parameter (blood) measurements• Personalized • Unique individual human genetic variation mandates individual treatment• Preventive • Design of therapeutic and preventive drugs/vaccines via systems approaches• Participatory: • Patient understands and participates in medical choices
  27. 27. P4 Medicine• Billions of data points for each individual• Focus on wellness• Early detection – Individual is own control (longitudinal data)• Disease stratification – Targeted therapies• Personalized treatments – Stratified disease and patients – matched with drug• Monitor Disease progression and therapy• Assess re-occurances
  28. 28. P4 will force a revision of business plans ofevery sector of healthcare industry—enormous economic opportunity • Medicine--diagnostics, therapy, prevention, wellness • Pharmaceuticals • Biotechnology Healthcare System • Diagnostics and Devices • IT for healthcare New ideas generally need new • Health insurance organizational structures • Nutrition • Assessments of environmental toxicities/influences • Academia and medical schools
  29. 29. ISB’s Strategic Partners for P4Medicine• Develop the tools and strategies for systems biology and P4 – State of Luxembourg--$100 million over 5 years• Bring P4 medicine to patients and validate its power – non-profit ISB-spinout P4 Medical Institute (P4MI) in partnership with Ohio State Medical School—two pilot projects—wellness and heart failure
  30. 30. Systems Biology drives a cycle of innovation Commercial opportunities Biology Cross-Disciplinary Systems Biology seeks to Culture address important and complex Team Science problems in biology that have previously been intractable.
  31. 31. ISB Companies• Accelerator o Commercializing cutting edge ideas in systems biology and related fields o Established 2003 o 11 new companies founded, 7 still operating o More than 750 business plans reviewed o 100 visits from all over the world o ISB receives founders equity / long-term endowment• ISB Spin Offs o Cytopeia - cell sorting – acquired - $1.1 million to ISB o Macrogenics - antibody therapies o Nanostring - digital mRNA counting o Integrated Diagnostics - multiparameter blood protein diagnostics o Accelerator o Future companies – wellness Bottom line o Raised $377 million in venture funding o These companies have 328 employees
  32. 32. Sustainability: Education All K-12 students should have access to research-based science education experiences. – Skilled Workforce – Educated Citizenry – Future scientists and engineers
  33. 33. Center for Inquiry Science • Center for Inquiry Science—embedded in ISB—6 full time professional teachers—focus on K-12 science education • Brings professional training to teachers for (inquiry-based) science • 2010 KCTS Golden Apple Award • Unique partnerships with school district • Representing 44% of student population in WA State • Approximately 1,000 teachers trained every year; more that 5,000 trained in last 5 years • Remarkable success closing the achievement gap for highest poverty schools.
  34. 34. SOME NUMBERS:I am 2 meters tallCells are ~30 um (30 millionths of a meter)I have ~10 trillion cells 10,000,000,000,000Human genome sequence finished in 2003 Cost ~$2.7 Billion – now ~$5000Each cell contains 23 pairs of chromosomesThat is ~3 billion (3,000,000,000 ) base pairs (AGCT)Stretched end to end- ~ 3m of DNA/cellDNA from all cells would stretch to the sun and back ~70 times~23,000 genes in humans (more proteins)>100,000 protein interactions~12,000 genes change their expression upon infection with Vaccinia virus
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