Hot New Drug Delivery
Technology
TecnoKal
480-704-3273
info@tecnokal.com

About Kurve and Talus
Founded in 2001
Technology:
Controlled Particle Dispersion (CPD)
Invented by sufferer of chronic
rhinosinusitis
Developed for the pharmaceutical industry
Clinical efficacy in humans and animals
Winner of the 2006 Frost and Sullivan Best
Practices Award
Now diversifying into cosmetic/cosmeceutical
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Kurve Technology
The Technology
Platform

Anatomical Considerations
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Technology comparison
distribution of medication in
nasal cavity
Typical Spray Bottle
CPD Deposition
Deposition
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Nasal Cavity Air Flow Patterns
90% of the air flow that is inhaled
through the nose follows the arrowed
patterns
It is essential to
cross this air
stream in order
to access the
mucosa beyond
the first 20% of
nasal cavity
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Controlled Particle Dispersion (CPD)
Aerodynamically controlled particle
Turbulent Flow
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Droplet Size
CPD can operate throughout the entire
spectrum
100
Droplet sizes ( m)
50
30
20
15
10
0
Nebulizer CPD Spray Bottle
CPD can control droplet size one micron
at a time.
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CPD Disruption: The Vortex and
Vortical Flow
In-vitro vs In-vivo models
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Viscosity Flexibility
Viscosity vs. Droplet Size
70
60
50
Droplets Size (microns)
40
30
20
10
0
1 15 30 45 60 75 90 500 1000 1500
Viscosity (cP)
DV(10) DV(50) DV(90)
Current technology can run viscosities only up
to 5 centipoise. CPD is capable of delivering
viscosities as high as 2,000cp.
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Technology Platform - 3000 variables -
Customize Device to the Formulation
Nosepiece
(3) Vortex Control
(6)
Droplet Separator
Geometry
(3) Cone Geometry
(3)
Droplet Generator
(6)
Air Feed
(3)
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Technology Platform
Customize Device to Product Application
Vertical, Horizontal, Angled,
Upside Down
Single or dual Nostril
Fine Control of Droplet Size, Atomization Rate and
Exit Velocity
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Kurve: 3 Rx Verticals – OTC
Talus: Cosmetics OTC and Rx
150 + Clinical Efficacy in
74
Drugs Humans
million
patients
Dose counting, lock outs, compliance monitoring, web downloads
Topical Systemic N2B
Talus Industries, LLC
Foundation, fragrances, anti-aging, skin care, spray tanners, etc.
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ViaNase ID
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Small, Silent Delivery
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Application to the Eye
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Single Dose Internal View
Droplet Generator
Single Dose Ampoule
Ampoule Docking Station/Droplet
Generator Feed
Air Source
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Features
Controlled particle dispersion
Controlled particle size
Controlled particle speed and exit velocity
Controlled viscosity
Controlled Atomization Rate
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ViaNase ID
Compliance monitoring
Physician monitoring
Dose counting and dose timing control
Lock-outs from illicit use
Generic & Competitive lock-out
Web-based downloads
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Features
Controlled particle dispersion
Controlled particle size
Controlled particle speed and exit velocity
Controlled viscosity
Controlled Atomization Rate
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Kurve Design Areas Beyond Nasal
Each of these design areas sought
Dry Powder out Kurve due to our success
significantly beyond the currently
available technologies
Eye Care
In process OTC/Rx**
Mouth (Buccal) Delivery
Throat Delivery (sans lung)
In process OTC
Consumer Products
Separate Vertical
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Benefits of CPD
Superior application to pump technology
Apply lotion/crème without use of hands
More uniform application of product on skin
Perfect for application on sensitive areas
More economic application
Computer controlled/adjustable color of make up
for matching skin tone everyday and throughout
the year.
CPD gives luxury fragrances and formulations
the “high tech touch”
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Cosmetic applications
Sunscreen Moisturizers
Fragrances
Evening Moisturizers
Formulations
Advanced night repair
Makeup
Vitamin C Topicals
Toiletries
Pigment Control Products
Spray Tanners
Advanced Treatment
Hydrating Serum Products
Cleansers Acne/Blemish Control
Toners Masks/Exfoliants
Anti-aging
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Cosmetic/Cosmeceuticals Samples
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For more information please contact
TecnoKal
480-704-3273
info@tecnokal.com