Linkedin Gen Script

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  • 39
  • Linkedin Gen Script

    1. 1. GenScript A World-leading Biology CRO Howard Huang Regional Business Manager for New England
    2. 2. About GenScript <ul><li>Founded in 2002 </li></ul><ul><li>More than 1,000 employees </li></ul><ul><li>Headquarters in Piscataway, NJ, USA </li></ul><ul><li>Facilities and branches: </li></ul>New Jersey, USA Nanjing, China Paris, France Tokyo, Japan
    3. 3. Key Facts <ul><li>One of the world-leading biology Contract Research Organization </li></ul><ul><li>The largest gene synthesis supplier in the world </li></ul><ul><li>The provider of custom protein, peptide, antibody , and cell line services with the best guarantee in the industry </li></ul><ul><li>Drug discovery platform including assay and screening, antibody drug development, bioprocess, structure biology, and animal model </li></ul><ul><li>ISO9001:2008 and AAALAC certificated </li></ul><ul><li>24-hour customer support </li></ul><ul><li>Global presence with subsidiaries in Europe and Asia, and major operations in China with advanced facility and >108,000 ft 2 lab space </li></ul><ul><li>Customers include major biotech firms, research institutions and the world's top pharmaceutical companies in over 70 countries </li></ul><ul><li>Seasoned science and business management team </li></ul>Your Innovation Partner in Drug Discovery!
    4. 4. Fast Growing Company Your Innovation Partner in Drug Discovery! Our Organic Growth Our Customers May 2009: GenScript gets VC from Kleiner Perkins Caufield & Byers (KPCB)
    5. 5. Investors <ul><li>Most respected venture capital firm in the world </li></ul><ul><li>Funded Genentech, Google, Amazon, Pacific Biosciences, etc </li></ul><ul><li>Invested in > 300 IT , life science, and biotech companies </li></ul>
    6. 6. Your Innovation Partner in Drug Discovery! <ul><ul><li>The new site spans on 100 acres of land. </li></ul></ul><ul><ul><ul><ul><li>7 buildings with 300,000 square feet of floor plan will function as offices, R&D, production, and experimental animal facilities . </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Capacity expansion: </li></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Gene synthesis: Beyond 5,000 kb per month </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Protein expression: More than 300 batches per month </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Antibody: More than 300 custom orders per month, maintenance of 2,000 catalog products </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Bioprocess: GLP grade bioproduction </li></ul></ul></ul></ul></ul>New Biology Facility in Jiangning, Nanjing
    7. 7. Your Innovation Partner in Drug Discovery!
    8. 8. New Peptide Facility in Pukou, Nanjing <ul><ul><li>27,000 square feet of floor plan will function as research and production facilities </li></ul></ul><ul><ul><li>Capacity expansion: </li></ul></ul><ul><ul><ul><ul><li>Standard peptide synthesis: 6,000 peptides per month </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Peptide library: up to 50,000 peptides per month </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Maintenance of more than 2,000 peptide products </li></ul></ul></ul></ul>Your Innovation Partner in Drug Discovery!
    9. 9. Drug Discovery Outsourcing Becomes Trend Your Innovation Partner in Drug Discovery!
    10. 10. The bottleneck in early drug discovery <ul><li>The decoding of the human genome and the rapid pace of biological research have generated numerous potential drug targets. </li></ul><ul><li>Assay Development and building screening cascades now become the limiting factors in early drug discovery. </li></ul><ul><li>Outsourcing has already been shown to dramatically increase the capacity of medicinal chemistry. </li></ul>Your Innovation Partner in Drug Discovery! Drug Targets Small / Big molecule High Affinity compound Drug Assay
    11. 11. Bottleneck: Bio-reagent Preparation <ul><li>Typical delay caused by reagent preparation time for a program is anywhere from 3-12 months. </li></ul><ul><li>Some programs simply cannot be initiated at all due to un-availability of appropriate validated bio-reagents. </li></ul>Your Innovation Partner in Drug Discovery! Assay Design (3-12 months) Bio-Reagent Preparation and Assay Setup (6-12 months) Screening (2-4 months)
    12. 12. Target Identification Target Validation Assay Development & Screening Lead Optimization Bio-reagent Center Bio-Assay Center Lead Optimiztion Center Your Innovation Partner in Drug Discovery! GenScript: Removing the bottleneck GenScript is providing a total solution from custom bio-reagent, assay development and screening for early drug discovery. Preclinical Drug Candidate
    13. 13. GenScript Factory: Assembly-Line Your Innovation Partner in Drug Discovery! Laboratory: Same person for different steps, uncontinuable mode GenScript Factory: Dedicated person for each position, continuable mode
    14. 14. Biology Research Services Our Biology Contract Research Services
    15. 15. Transforming Molecular Biology Gene Synthesis — Any gene you desire! Synthesize genes OptimumGene TM Codon Optimization Large-Scale Gene Synthesis Cloning — Any construct you want to build! PCR Cloning/Subcloning GenPool TM ORF Cloning KI & KO Vector Construction Custom vector construction Mutagenesis — Any variant from your design! Mutagenesis Service Site-Directed Mutagenesis Libraries Sequential Permutation Scanning Libraries Randomized and Degenerated Libraries Plasmid Preparation — Any amount to fit your plan! Flexible Scale: 100 μg to 1,000 mg Low Endotoxin Levels: <5 EU/mg Largest Gene Synthesis Supplier in the World
    16. 16. Your Innovation Partner in Drug Discovery!
    17. 17. OptimumGene TM - Codon Optimization <ul><li>GenScript OptimumGene TM Gene Design system is a proprietary gene optimization technology that can alter both naturally occurring and recombinant gene sequences to achieve the highest possible levels of productivity in any given expression system. </li></ul>
    18. 18. OptimumGene TM – Cases Study Fig. α. Expression Result of Protein α after Gene Optimization. The expression level of Protein A using GenScript’s OptimumGene TM optimization is 3 times more than that of competitor’s. Fig. β. Expression Result of Protein β after Gene Optimization. The expression level of Protein B using GenScript’s OptimumGene TM optimization is 13 times more than that of competitor’s.
    19. 19. One-Stop Protein Service Your Innovation Partner in Drug Discovery!
    20. 20. Your Innovation Partner in Drug Discovery!
    21. 21. Your Innovation Partner in Drug Discovery!
    22. 22. <ul><li>DHFR CHO expression system </li></ul><ul><ul><li>No patent or IP issue </li></ul></ul><ul><li>Research grade stable cell line (12-14 weeks) </li></ul><ul><ul><li>Transient expression evaluation </li></ul></ul><ul><ul><li>Transfection and screening </li></ul></ul><ul><ul><li>Stability study and delivery of top 3 clones </li></ul></ul><ul><li>Production grade stable cell line (20-24 weeks) </li></ul><ul><ul><li>Include all work for research cell line creation </li></ul></ul><ul><ul><li>Plus 3 rounds of MTX amplification and subcloning of top 3 clones </li></ul></ul><ul><li>Other stable mammalian cell lines upon request </li></ul>Stable Gene Expression Your Innovative Partner in Drug Discovery!
    23. 23. <ul><li>Custom Peptide Synthesis Services </li></ul>Custom Peptide Synthesis Services Non-GMP Peptides GMP Peptides Standard Peptide Synthesis High complexity and purity Long peptides up to 200 aa High success rate ≥ 95% Peptide Libraries Rapid parallel platform Competitive prices Guaranteed delivery Flexible screening tools Cosmetic Peptides FlexPeptide TM technology Comprehensive documents Batch size from mg to 2 kg Peptides up to 50 aa Recombinant Peptides Flexible technology Variety of modifications Any length, any sequence, any scale Leading the industry standard on peptide success rate …
    24. 24. Guaranteed Antibody Services Custom pAb and mAb Services Catalog antibodies Express services Best guaranty in the industry pAb Services Affinity-Purified pAb Phospho-Specific pAb Express Antibody TM Services Species: rabbit, goat/sheep, chicken, mouse, rat, etc mAb services MonoExpress TM Antibody Services mAb Production Services Most Popular: Phospho-Specific pAb Package Large Scale Antibody Production Services Additional Services Ab Modification Ab Purification Ab Characterization Cell Line Storage Peptide Synthesis Services Immunoassay Development Services for Drug Discovery & Clinical Studies Leading the industry standard on antibody guarantee …
    25. 25. <ul><li>Best guarantees in the Industry </li></ul><ul><ul><li>For Antibody product generated in any host using any qualified antigen, we guarantee ELISA titer 1:32,000 or better. </li></ul></ul><ul><ul><li>For Monoclonal Antibody product generated in any host using any qualified antigen, we guarantee two positive clones . </li></ul></ul><ul><ul><li>For both Polyclonal and Monoclonal antibody product generated using qualified protein antigen, we guarantee positive Western blot results . </li></ul></ul>Antibody Services Your Innovation Partner in Drug Discovery!
    26. 26. Your Innovation Partner in Drug Discovery!
    27. 27. <ul><ul><li>Given a target, we will delivery HTS-ready assays to you </li></ul></ul>Seamless Bio-Assay Center <ul><li>GPCR Assay Services </li></ul><ul><li>Custom GPCR Stable Cell Line Services </li></ul><ul><li>Cell-Based Assay Development </li></ul><ul><li>Compound Primary & Secondary Screening </li></ul><ul><li>GPCR Profiling </li></ul><ul><li>Ion Channel Assay Services </li></ul><ul><li>Custom Ion Channel Services </li></ul><ul><li>Functional Profiling Assays </li></ul><ul><li>Compound Screening </li></ul><ul><li>Enzyme Assay Services </li></ul><ul><li>Kinase & Protease Assay Development </li></ul><ul><li>Kinase & Protease Compound Screening </li></ul><ul><li>Kinase & Protease Compound Profiling </li></ul><ul><li>Other Enzyme Assays </li></ul><ul><li>One-Stop Assay Services </li></ul><ul><li>Target-to-Assay Solutions </li></ul><ul><li>Assay Reagent Preparation </li></ul><ul><li>HTS-ready formatting </li></ul><ul><li>Compound profiling </li></ul>
    28. 28. Your Innovation Partner in Drug Discovery!
    29. 29. <ul><li>Assay dev and screening </li></ul><ul><ul><li>GPCR </li></ul></ul><ul><ul><li>Ion channel </li></ul></ul><ul><ul><li>Enzyme </li></ul></ul><ul><ul><ul><li>Kinase </li></ul></ul></ul><ul><ul><ul><li>Protease </li></ul></ul></ul><ul><ul><ul><li>Other </li></ul></ul></ul><ul><ul><li>Nuclear receptor </li></ul></ul><ul><ul><li>Transport </li></ul></ul><ul><ul><li>More </li></ul></ul><ul><li>Oncology drug discovery </li></ul><ul><ul><li>In vitro </li></ul></ul><ul><ul><ul><li>Proliferation </li></ul></ul></ul><ul><ul><ul><li>Colony formation </li></ul></ul></ul><ul><ul><ul><li>Cytotoxicity </li></ul></ul></ul><ul><ul><ul><li>Cell adhesion </li></ul></ul></ul><ul><ul><ul><li>Migration & invasion </li></ul></ul></ul><ul><ul><ul><li>Angiopoiesis </li></ul></ul></ul><ul><ul><ul><li>Apoptosis </li></ul></ul></ul><ul><ul><ul><li>Cell death </li></ul></ul></ul><ul><ul><ul><li>Genotyping </li></ul></ul></ul><ul><ul><ul><li>RNAi </li></ul></ul></ul><ul><ul><li>In vivo </li></ul></ul><ul><ul><ul><li>Animal efficacy </li></ul></ul></ul><ul><ul><ul><li>PK </li></ul></ul></ul>Your Innovation Partner in Drug Discovery! <ul><li>Antibody drug discovery </li></ul><ul><ul><li>ADCC </li></ul></ul><ul><ul><li>CDC </li></ul></ul><ul><ul><li>BiaCore SPR </li></ul></ul><ul><ul><li>ELISA </li></ul></ul><ul><ul><li>TNF-alpha induced cytotoxicity </li></ul></ul><ul><li>Safety </li></ul><ul><li>assessment </li></ul><ul><ul><li>Cardiotoxicity </li></ul></ul><ul><ul><ul><li>hERG binding </li></ul></ul></ul><ul><ul><ul><li>hERG patch clamp </li></ul></ul></ul><ul><ul><ul><li>hKv1.5 </li></ul></ul></ul><ul><ul><ul><li>hNav1.5 </li></ul></ul></ul><ul><ul><ul><li>Cav1.3 </li></ul></ul></ul><ul><ul><li>Drug interactions </li></ul></ul><ul><ul><li>Heptotoxicity </li></ul></ul><ul><ul><li>HepG2 inhibition </li></ul></ul><ul><ul><li>Gentoxicity </li></ul></ul><ul><ul><li>Mitochondrial toxicity </li></ul></ul>
    30. 30. Antibody Drug Development Center Your One-Store Shop for Success
    31. 31. Innovation & Technology <ul><li>Innovative technologies for enhanced services </li></ul><ul><li>Gene-on-Demand TM gene synthesis technology </li></ul><ul><li>- best and most economic gene synthesis </li></ul><ul><li>FlexChem TM ligation technology </li></ul><ul><li>- peptide synthesis up to 200 amino acids </li></ul><ul><li>CloneEZ TM seamless cloning technology </li></ul><ul><li>- state-of-art cloning into any vector at any site </li></ul><ul><li>Nanotechnology for adjuvant mixing </li></ul><ul><li>- induction of enhanced immune response </li></ul><ul><li>Diversified expression systems </li></ul><ul><li>- bacteria, yeast, insect cells, and mammalian cells </li></ul><ul><li>T-Max TM adjuvant </li></ul><ul><li>- increased titer of at least ten times, and reduced cost </li></ul><ul><li>FoldingArt TM technology </li></ul><ul><li>- refold rate of 95% for inclusion bodies and proteins (virus expression) </li></ul><ul><li>OptimumAntigen TM antigen design </li></ul><ul><li>- optimized antigen design </li></ul><ul><li>293TGE TM system </li></ul><ul><li>- most efficient transient expression system </li></ul><ul><li>OptimumGene TM codon optimization technology </li></ul><ul><li>- optimized gene expression </li></ul>
    32. 32. Full IP Protection <ul><li>A secure web-enabled resource to list the program progress/reagent availability for each client. </li></ul>Your Innovation Partner in Drug Discovery!
    33. 33. Business Models
    34. 34. Thank You! Howard Huang Regional Business Manager New England [email_address]

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