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  • 39

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  • 1. GenScript A World-leading Biology CRO Howard Huang Regional Business Manager for New England
  • 2. About GenScript
    • Founded in 2002
    • More than 1,000 employees
    • Headquarters in Piscataway, NJ, USA
    • Facilities and branches:
    New Jersey, USA Nanjing, China Paris, France Tokyo, Japan
  • 3. Key Facts
    • One of the world-leading biology Contract Research Organization
    • The largest gene synthesis supplier in the world
    • The provider of custom protein, peptide, antibody , and cell line services with the best guarantee in the industry
    • Drug discovery platform including assay and screening, antibody drug development, bioprocess, structure biology, and animal model
    • ISO9001:2008 and AAALAC certificated
    • 24-hour customer support
    • Global presence with subsidiaries in Europe and Asia, and major operations in China with advanced facility and >108,000 ft 2 lab space
    • Customers include major biotech firms, research institutions and the world's top pharmaceutical companies in over 70 countries
    • Seasoned science and business management team
    Your Innovation Partner in Drug Discovery!
  • 4. Fast Growing Company Your Innovation Partner in Drug Discovery! Our Organic Growth Our Customers May 2009: GenScript gets VC from Kleiner Perkins Caufield & Byers (KPCB)
  • 5. Investors
    • Most respected venture capital firm in the world
    • Funded Genentech, Google, Amazon, Pacific Biosciences, etc
    • Invested in > 300 IT , life science, and biotech companies
  • 6. Your Innovation Partner in Drug Discovery!
      • The new site spans on 100 acres of land.
          • 7 buildings with 300,000 square feet of floor plan will function as offices, R&D, production, and experimental animal facilities .
          • Capacity expansion:
            • Gene synthesis: Beyond 5,000 kb per month
            • Protein expression: More than 300 batches per month
            • Antibody: More than 300 custom orders per month, maintenance of 2,000 catalog products
            • Bioprocess: GLP grade bioproduction
    New Biology Facility in Jiangning, Nanjing
  • 7. Your Innovation Partner in Drug Discovery!
  • 8. New Peptide Facility in Pukou, Nanjing
      • 27,000 square feet of floor plan will function as research and production facilities
      • Capacity expansion:
          • Standard peptide synthesis: 6,000 peptides per month
          • Peptide library: up to 50,000 peptides per month
          • Maintenance of more than 2,000 peptide products
    Your Innovation Partner in Drug Discovery!
  • 9. Drug Discovery Outsourcing Becomes Trend Your Innovation Partner in Drug Discovery!
  • 10. The bottleneck in early drug discovery
    • The decoding of the human genome and the rapid pace of biological research have generated numerous potential drug targets.
    • Assay Development and building screening cascades now become the limiting factors in early drug discovery.
    • Outsourcing has already been shown to dramatically increase the capacity of medicinal chemistry.
    Your Innovation Partner in Drug Discovery! Drug Targets Small / Big molecule High Affinity compound Drug Assay
  • 11. Bottleneck: Bio-reagent Preparation
    • Typical delay caused by reagent preparation time for a program is anywhere from 3-12 months.
    • Some programs simply cannot be initiated at all due to un-availability of appropriate validated bio-reagents.
    Your Innovation Partner in Drug Discovery! Assay Design (3-12 months) Bio-Reagent Preparation and Assay Setup (6-12 months) Screening (2-4 months)
  • 12. Target Identification Target Validation Assay Development & Screening Lead Optimization Bio-reagent Center Bio-Assay Center Lead Optimiztion Center Your Innovation Partner in Drug Discovery! GenScript: Removing the bottleneck GenScript is providing a total solution from custom bio-reagent, assay development and screening for early drug discovery. Preclinical Drug Candidate
  • 13. GenScript Factory: Assembly-Line Your Innovation Partner in Drug Discovery! Laboratory: Same person for different steps, uncontinuable mode GenScript Factory: Dedicated person for each position, continuable mode
  • 14. Biology Research Services Our Biology Contract Research Services
  • 15. Transforming Molecular Biology Gene Synthesis — Any gene you desire! Synthesize genes OptimumGene TM Codon Optimization Large-Scale Gene Synthesis Cloning — Any construct you want to build! PCR Cloning/Subcloning GenPool TM ORF Cloning KI & KO Vector Construction Custom vector construction Mutagenesis — Any variant from your design! Mutagenesis Service Site-Directed Mutagenesis Libraries Sequential Permutation Scanning Libraries Randomized and Degenerated Libraries Plasmid Preparation — Any amount to fit your plan! Flexible Scale: 100 μg to 1,000 mg Low Endotoxin Levels: <5 EU/mg Largest Gene Synthesis Supplier in the World
  • 16. Your Innovation Partner in Drug Discovery!
  • 17. OptimumGene TM - Codon Optimization
    • GenScript OptimumGene TM Gene Design system is a proprietary gene optimization technology that can alter both naturally occurring and recombinant gene sequences to achieve the highest possible levels of productivity in any given expression system.
  • 18. OptimumGene TM – Cases Study Fig. α. Expression Result of Protein α after Gene Optimization. The expression level of Protein A using GenScript’s OptimumGene TM optimization is 3 times more than that of competitor’s. Fig. β. Expression Result of Protein β after Gene Optimization. The expression level of Protein B using GenScript’s OptimumGene TM optimization is 13 times more than that of competitor’s.
  • 19. One-Stop Protein Service Your Innovation Partner in Drug Discovery!
  • 20. Your Innovation Partner in Drug Discovery!
  • 21. Your Innovation Partner in Drug Discovery!
  • 22.
    • DHFR CHO expression system
      • No patent or IP issue
    • Research grade stable cell line (12-14 weeks)
      • Transient expression evaluation
      • Transfection and screening
      • Stability study and delivery of top 3 clones
    • Production grade stable cell line (20-24 weeks)
      • Include all work for research cell line creation
      • Plus 3 rounds of MTX amplification and subcloning of top 3 clones
    • Other stable mammalian cell lines upon request
    Stable Gene Expression Your Innovative Partner in Drug Discovery!
  • 23.
    • Custom Peptide Synthesis Services
    Custom Peptide Synthesis Services Non-GMP Peptides GMP Peptides Standard Peptide Synthesis High complexity and purity Long peptides up to 200 aa High success rate ≥ 95% Peptide Libraries Rapid parallel platform Competitive prices Guaranteed delivery Flexible screening tools Cosmetic Peptides FlexPeptide TM technology Comprehensive documents Batch size from mg to 2 kg Peptides up to 50 aa Recombinant Peptides Flexible technology Variety of modifications Any length, any sequence, any scale Leading the industry standard on peptide success rate …
  • 24. Guaranteed Antibody Services Custom pAb and mAb Services Catalog antibodies Express services Best guaranty in the industry pAb Services Affinity-Purified pAb Phospho-Specific pAb Express Antibody TM Services Species: rabbit, goat/sheep, chicken, mouse, rat, etc mAb services MonoExpress TM Antibody Services mAb Production Services Most Popular: Phospho-Specific pAb Package Large Scale Antibody Production Services Additional Services Ab Modification Ab Purification Ab Characterization Cell Line Storage Peptide Synthesis Services Immunoassay Development Services for Drug Discovery & Clinical Studies Leading the industry standard on antibody guarantee …
  • 25.
    • Best guarantees in the Industry
      • For Antibody product generated in any host using any qualified antigen, we guarantee ELISA titer 1:32,000 or better.
      • For Monoclonal Antibody product generated in any host using any qualified antigen, we guarantee two positive clones .
      • For both Polyclonal and Monoclonal antibody product generated using qualified protein antigen, we guarantee positive Western blot results .
    Antibody Services Your Innovation Partner in Drug Discovery!
  • 26. Your Innovation Partner in Drug Discovery!
  • 27.
      • Given a target, we will delivery HTS-ready assays to you
    Seamless Bio-Assay Center
    • GPCR Assay Services
    • Custom GPCR Stable Cell Line Services
    • Cell-Based Assay Development
    • Compound Primary & Secondary Screening
    • GPCR Profiling
    • Ion Channel Assay Services
    • Custom Ion Channel Services
    • Functional Profiling Assays
    • Compound Screening
    • Enzyme Assay Services
    • Kinase & Protease Assay Development
    • Kinase & Protease Compound Screening
    • Kinase & Protease Compound Profiling
    • Other Enzyme Assays
    • One-Stop Assay Services
    • Target-to-Assay Solutions
    • Assay Reagent Preparation
    • HTS-ready formatting
    • Compound profiling
  • 28. Your Innovation Partner in Drug Discovery!
  • 29.
    • Assay dev and screening
      • GPCR
      • Ion channel
      • Enzyme
        • Kinase
        • Protease
        • Other
      • Nuclear receptor
      • Transport
      • More
    • Oncology drug discovery
      • In vitro
        • Proliferation
        • Colony formation
        • Cytotoxicity
        • Cell adhesion
        • Migration & invasion
        • Angiopoiesis
        • Apoptosis
        • Cell death
        • Genotyping
        • RNAi
      • In vivo
        • Animal efficacy
        • PK
    Your Innovation Partner in Drug Discovery!
    • Antibody drug discovery
      • ADCC
      • CDC
      • BiaCore SPR
      • ELISA
      • TNF-alpha induced cytotoxicity
    • Safety
    • assessment
      • Cardiotoxicity
        • hERG binding
        • hERG patch clamp
        • hKv1.5
        • hNav1.5
        • Cav1.3
      • Drug interactions
      • Heptotoxicity
      • HepG2 inhibition
      • Gentoxicity
      • Mitochondrial toxicity
  • 30. Antibody Drug Development Center Your One-Store Shop for Success
  • 31. Innovation & Technology
    • Innovative technologies for enhanced services
    • Gene-on-Demand TM gene synthesis technology
    • - best and most economic gene synthesis
    • FlexChem TM ligation technology
    • - peptide synthesis up to 200 amino acids
    • CloneEZ TM seamless cloning technology
    • - state-of-art cloning into any vector at any site
    • Nanotechnology for adjuvant mixing
    • - induction of enhanced immune response
    • Diversified expression systems
    • - bacteria, yeast, insect cells, and mammalian cells
    • T-Max TM adjuvant
    • - increased titer of at least ten times, and reduced cost
    • FoldingArt TM technology
    • - refold rate of 95% for inclusion bodies and proteins (virus expression)
    • OptimumAntigen TM antigen design
    • - optimized antigen design
    • 293TGE TM system
    • - most efficient transient expression system
    • OptimumGene TM codon optimization technology
    • - optimized gene expression
  • 32. Full IP Protection
    • A secure web-enabled resource to list the program progress/reagent availability for each client.
    Your Innovation Partner in Drug Discovery!
  • 33. Business Models
  • 34. Thank You! Howard Huang Regional Business Manager New England [email_address]