Organizational culture has been extensively studied over recent decades. “... culture isn’t just one aspect of the game – it is the game” said Gerstner (2002) the former CEO of IBM who lead the company in its historic turnaround in the late 90s. Culture is a set of values, beliefs, common understanding, thinking and norms for behaviors that are shared by all members of a society. You cannot precisely define it, but you can sense it and feel it. This paper will show that corporate culture has a strong influences on the organizational effectiveness, incl. its financial performance. An organizational culture model developed by Daniel Denison (1990) of IMD business school, Switzerland will be introduced to have a better understanding how corporate culture works in effective organizations in contras with ineffective organizations. Some best practice examples from China, Japan and a global cross-cultural study will be introduced. Finally the national culture issues in implementing the model that developed in western culture context in Asia will be discussed.