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fMRI Results

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  • 1. Harnessing the power and appeal oftechnology to improve kids’ health 2!
  • 2. Our Model! research! innovation! customer input! 3!
  • 3. Re-Mission! •  20 levels! •  7 cancer types! •  Objectives: kill cells, manage side-effects and complications! •  Weapons: chemo, radiation, antibiotics, stool softener! 4!
  • 4. PEDIATRICS August 2008!RE-MISSION WORKS!•  Improved treatment adherence! –  16% increase in antibiotic doses! –  Blood chemo levels 20% higher!•  Improved cancer knowledge!•  Greater self-efficacy: Increased belief in ability to control/cope with cancer! 5!
  • 5. Identifying the mechanisms of action in Re-Mission! Knowledge and learning are only part of the story 6!
  • 6. Identifying the mechanisms of action in Re-Mission! ? Treatment! adherence! 7 7!
  • 7. Re-Mission Works – But How? Identifying the mechanisms of action in Re-Mission! Emotion/! Motivation! Treatment! adherence! Knowledge! Re-Mission Attitudes Study! Jennifer Aaker, Ph.D., Stanford University! 8 8!
  • 8. Identifying the mechanisms of action in Re-Mission! How does videogame play influence real-life behavior?! ? Interactivity and Reward-Related Neural Activation During a Serious Videogame! ! h#p://dx.plos.org/10.1371/journal.pone.0033909   ! 9 9!
  • 9. Identifying the mechanisms of action in Re-Mission! 10 min fMRI T2*! Rest! Rest   Rest   Rest   Rest   Rest   Rest   Play! Rest! 10!
  • 10. Identifying the mechanisms of action in Re-Mission! Interactive play ! Passive exposure! Caudate! Caudate! Thalamus! Thalamus!Hippocampus! Hippocampus! 11 11!
  • 11. iden%fying  mechanisms  of  ac%on   Identifying the mechanisms of action in Re-Mission! Results! •  Game-based interventions can be powerful tools for activating health-supportive behaviors! •  Psychological outcomes (knowledge, self-efficacy)! •  Treatment-related behavior (chemo / antibiotic adherence)! •  Interactive game-play has wide impact on the brain! •  Learning / knowledge ! Interactivity and Reward-Related Neural •  Motivation / emotion! Activation! During a Serious Videogame! •  Hippocampal activation may play a role in generalizing in-game experience to real-life behavior! Brian Knutson, Ph.D., Stanford University ! http://dx.plos.org/10.1371/journal.pone.0033909! Implications! •  Psychological “recipe” for positive behavior change! •  Neural biomarkers for optimizing interventions ! 12   12!
  • 12. Thank you!

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